جستجوی مقالات مرتبط با کلیدواژه « hyoscine » در نشریات گروه « پزشکی »

Delivery is an experience with full of stress, with pain, fatigue and fear. The fear of labor pain causes their tendency to cesarean section. It is believed that labor pain is the most painful pain experienced by human beings. This pain occurs at different stages of delivery. Labor duration is a factor affecting pregnancy outcomes and contributing to damages inflicted on mothers and their fetus. Present study was performed with aim of comparing effects of transcutaneous electrical nerve stimulation (TENS) with those of pharmaceutical hyoscine – promethazine compound on duration of the first phase of labor in 2015.

This research was done by clinical ergometric method on 84 eligible pregnant women (42 in TENS group; 42 in hyoscine – promethazine group) referring to the Martyr Chamran Hospital of Kangavar division. At the onset of active phase, medication group were injected once with 20 mg of hyoscine and 25 mg of promethazine intramuscularly simultaneously. For non – medication group, TENS device was employed, with a pair of upper electrodes being placed between L1-T10 and a pair of lower ones being placed between S2-S4 on both sides of spinal column. Two groups were tested for duration of the first phase of labor.

Variables of age, body mass index(BMI), pregnancy age, dilatation of the second phase of labor and infant weight were tasted in both groups showing no significant differences in this regard (p>0.05). In the first phase of labor, no statistically significant difference was observed between 2 groups in terms of the means of contraction number means (p=0.23). But during of the first phase of labor exhibited some significant difference between 2 groups (p=0.002); in TENS group, mean duration of the first phase was shorter than hyoscine-promethazine group.

compared to pharmaceutical hyoscine-promethazine compound, TENS further shortened duration of the first phase of labor; therefore, it is recommended that TENS be used to shorten labor duration.

Datura plants cause poisoning in addition to properties and therapeutic applications in consumer and contain hyoscine, hyoscyamine, scopolamine and atropine with anticholinergic properties, which blocks peripheral and central muscarinic receptors. Introducing patient: In this report, a case of death due to poisoning by eating Datura seeds diagnosed with poisoning and autopsy is presented. A 24-year-old man after taking an unspecified amount of Datura seeds in order to benefit from some of the health benefits of the Datura plant showed symptoms of alertness, lower blood pressure and reduced sensory reflexes to treat will be transferred to the hospital. Hematuria and other clinical signs and symptoms of bleeding in the digestive system were revealed. Despite the use of the treatments such as blood transfusions and medications including benzodiazepines, these treatments were not effective, and death occurred. Necropsy findings included yellowing of the skin, pallor, bleeding, bleeding under the conjunctiva, jaundice in the sclera, signs of restoration in the chest, and minor scratches and a bruise on the right side and parallel to the surface of the abdomen and waist were observed. Finally, considering the history of consuming the Datura seed, clinical and paraclinical findings as well as necropsy findings with GCMS confirmation of availability of hyoscine, hyoscyamine, scopolamine in victim’s blood, the cause of death for him was reported poisoning with Datura seeds. In conclusion, the availability of wildlife seed and the sale of it in traditional herbal markets, it makes it essential to reduce the harmful effects of this product with increasing the knowledge of the community about Datura and similar herbal remedies.

Several physical and psychological factors affect the severity and duration of labor pain. Factors such as maternal age, parity, cervical position at the onset of labor, and the relationship between the size and position of the embryo with the size of the canal of delivery are important factors in the severity of labor pain. Effective psychosocial factors that may affect physical factors include fear, anxiety, cultural beliefs and companionship in the delivery room. The severity of pain varies from one person to another, and according to published reports, 15% have mild pain, 35% have moderate pain, 30% have severe pain, and 20% have reported uncommitted pain. Considering the painful nature of labor, the present study was conducted to compare the effect of TENS with hyoscine-promethazine on reducing the frequency of labor pain in the active phase of labor.
By a clinical ergometric method, this research was done on 84 eligible pregnant women (42 in TENS group; 42 in hyoscine- promethazine group) referring to Shahid Chamran Hospital of Kangavar city. When active phase of labor began, 20 mg of hyoscine and 25 mg of promethazine were simultaneously administered to the medication group intramuscularly. For TENS group, TENS device was used, with a pair of upper electrodes being between L1-T10 and a pair of lower ones between S2-S4 on both sides of spinal column. Pain scores were studied under per- and post- intervention conditions for 2 groups. Collected data was analyzed by using SPSS software, chi- square test and independent t-test at p Two groups were tested for variables of age, body mass index (BMI), pregnancy age, dilatation at the time of admission, exhibiting no significant differences (p>0.05). The means of contraction duration (p>0.05) and of contraction number (p>0.05) did not differ significantly for 2 groups. But results from comparison of the mean pain scares of 2 groups of studied pregnant women showed that it was significantly lower for TENS group throughout active labor phase at different dilatations than for the other group (hyoscine- promethazine) (p TENS relieves labor pain; therefore, it is recommended to use it for this purpose.

The general experience of women from childbirth process is an important outcome. The quality of these experiences affect the mother and her babies’ health and their relationship, sexual activity and desire to having next child in future. Hot shower and intravenous injection of hyoscine are utilized to promote childbirth experience and increased satisfaction of childbirth; however, their effects are not thoroughly investigated. This study was performed with aim to assess the effects of hot shower and intravenous injection of hyoscine on childbirth experience in nulliparous women.
This randomized controlled clinical trial was conducted on 162 nulliparous women who were hospitalized in 29-Bahman hospital of Tabriz in 2015. The participants were assigned into 3 groups of 54 cases (intravenous hyoscine, hot shower, and control) by block randomization. In the intervention groups, hyoscine and hot shower were applied at dilatation of 4 cm and 7 cm. The control group received routine cares. Childbirth experience questionnaire was completed by the participants 12 to 24 hours after childbirth; the higher score showed better experience. Data were analyzed by SPSS software (version 20) and One-way ANOVA and Chi-square, Fisher-Exact, and Kruskal-Wallis tests. P The mean score of childbirth experience was 44.3±5.7 in the hyoscine group, 42.3±11.7 in the hot shower group and 39.0±10.6 in the control group. The mean score of childbirth experience was significantly higher in the hyoscine group (P= 0.014) and the hot shower group (P= 0.046) compared with the control group. However, there was no significant difference between two intervention groups (P=0.401). There was no significant difference between the groups in terms of satisfaction of childbirth and oxytocin consumption (P>0.05).
Using of non-pharmacological method of hot shower can improve childbirth experience similar to hyoscine group; therefore, using of this non-pharmacological supportive method is recommended to the mothers.

Hyoscine isone the drugs commonly used to improve effacement and dilatation that its efficacy is still questioned. So, this study was performed with aim to evaluate the effect of intravenous hyoscine in labor process of primiparous women.
The triple-blind clinical trial was performed on 300 primiparous pregnant women with term gestational age referred to Kerman Afzalipour hospital in 2015. Samples were randomly divided into two groups of intervention (received hyoscine) and control (received distilled water as placebo). The intravenous single dose injection was conducted at 4 cm dilation and 30-40% of effacement. Maternal status was recorded every one hour. Data were analyzed by software SPSS (version 17) and t-test, Chi-square, correlation and logistic regression. P Mean length of active phase and second stage of labor was higher in case group than control group and the difference between two groups was statistically significant. Also, the mean changes in effacement 1 and 2 hours after injection was statistically significant. While cervical dilatation 1 and 2 hours after injection was not significantly different between case and control groups. The incidence of transient tachycardia and bradycardia fetal heart rate occurred in 78% of case group and in 12.66% of control group (P Mean length of active phase and second stage of labor was higher in those who received hyoscine than the control group. Also, due to the transient drop in occurrence of fetal heart rate which leads to hasty conclusions about the state of fetus, it is better to perform further studies to provide more accuracy in the use of this drug in labor process.

Hyoscine (scopolamine) as an anticholinergic and antinociceptive drug، has some side effects. Recently، it has been received much attention to the interactions between synthetic drugs and herbal extracts and their pharmacological responses which made the possibility of using the minimum dose and low side effects. In this study، we evaluated the effect of Salvia officinale extract، hyoscine and their combinationin management of pain in rats. In this experimental study animals were divided randomly into eight groups (n=6). Hyoscine (0. 5، 1 and 5 mg/kg) administrated by intraperitoneal injection and extract (100 and 200 mg/kg) was administered by gavages one hour before administration of hyoscine. Thirty minutes after treatment، rats were subjected to tail-flick test and data were recorded. Statistical significance was considered at p<0. 05. Administration of hyoscine at doses of 0. 5، 1 and 5 mg/kg created significant analgesic effects compared to control group in the Tail-flick test (p<0. 05، p<0. 01 and p<0. 05، respectively). The combination of S. officinale extract (100 and 200 mg/kg) and hyoscine (1 mg/kg) significantly increased the pain threshold than the groups receiving only extract or hyoscine. Our data showed that hydroethanolic extract of Salvia officinale has an important antinociceptive effect which can lead to decreased pain in rats. Sincehyoscine as an analgesic drug has some side effects، combination of Salvia officinale extractand hyoscine can decrease the needed dose of hyoscine and itsside effects.

Prevention and control of shivering after surgery is of significant importance and different methods are used for this purpose. In this study، three drugs of dexamethason، petidine and hyoscine were compared in the prevention of postoperative shivering. In a clinical trial study، 90 patients who were candidates for laparascopic cholesistectomia were selected and randomly divided in three equal groups. The first group received 0. 5 mg/kg pethidine، the second group 0. 1 mg/kg dexamethason and the third group 0. 15 mg/kg hyoscine. The prevalence of postoperative shivering was compared between the three groups. The data was analyzed using SPSS software. In three groups of pethidine، hyoscine and dexamethason، 60%، 43. 3% and 54. 4% had no postoperative shivering، respectively. In these groups، 20. 0%، 13. 3% and 23. 3% had mild shivering، 16. 7%، 33. 3% and 6. 7% had moderate shivering and 3. 3. %، 10. 0% and 10. 0% had sever postoperative shivering، respectively، and no statistically difference were seen between the three groups (P = 0. 16). Pain was lower in pethidine group than the other groups. In addition، dexamethasone and hyoscine had positive effects of postoperative nausea and methoclopramide consumption. Three drugs of pethidine، hyoscine and dexamethason have not different effects of prevention of postoperative shivering but the complications such were different. We recommend that in future studies، the combined effect of these drugs on postoperative complications in patients undergoing surgical procedures could be studied.

Background and

Fluctuations in the heart rate can be affected by many factors such as breathing. The amplitude of heart rate variability during inhalation and exhalation provides a quantitative measure that puts the estimate of cardiac vagal function which is considered. The aim of this study was to investigate the effect of a single dose of hyoscine-N-butylbromide (hyoscine) on the amplitude of heart rate variability, namely cardiac vagal activity.

15 healthy young male subjects participated in the study. Each subject came to the laboratory twice with one week interval. Before and one hour after intramuscular injection of hyoscine or placebo, normal and deep breathing tests were performed every 10 minutes. The amplitude of respiratory sinus arrhythmia (RSA) associated with cardiac vagal activity between periods before and after administration of the drug/ or placebo were analyzed by RM_ANOVA.

Comparing with normal breathing, deep breathing increases the amplitude of the RSA. The One way ANOVA of RSA showed that hyoscine reduced the RSA amplitude that at 50 min after injection returned to basal level. Similar results were also observed during normal breathing test except that RSA amplitude at 40 min after injection of hyoscine returned to baseline.

Overall, the findings of this study showed that intramuscular injection of 20 mghyoscine reduces cardiac vagal activity that returned to base line 40-50 minutes after the injection.

Despite wide use of hyoscine by midwives and doctors as an adjunct to labor, the obstetrics literature contains few references to the effect of this drug. This study was a double blinded, randomized controlled trial of primigravidas in Iran to determine the effects of hyoscine intravenous injection on parturition (labor).

One hundred primigravidas in uncomplicated spontaneous labor with cervical dilation less than 4 cm and cervical effacement < 50% were randomly assigned into two groups the experimental group ( N = 50 ) receiving 20 mg hyoscine and the control group ( N = 50 ) receiving placebo, with predetermined codes injected at the beginning of the active phase of labor. The groups were compared for labor progress, fetal tachycardia and bradycardia after 0.5 and 1h of injection, Apgar score and birth weight. Statistical methods for normally distributed variables included 2- tailed student T test and chi- square analysis. The accepted level of significance was p < 0.05.

The two groups were similar in respect to maternal age, gestational age , initial cervical effacement & dilation and mean birth weight. The mean change in the cervical effacement and dilation after 1 & 2 h of injection was significantly higher in those receiving hyoscine (p< 0.0001). There was a significant difference in the duration of active phase and second stage of labor in the two groups ( p < 0.0001 ). Fetal tachycardia and bradycardia occurred more frequently in patients in the hyoscine group as compared to the control group but the difference was not significant. The difference between the mean first and fifth- minute Apgar score was not significant, too.

This small study suggests the benefits of a single dose of hyoscine for labor progress and represents the first attempt to evaluate this medication. However, larger randomized studies are needed to establish the efficacy, safety, and optimal dose of hyoscine .

Hyoscyamus is one of the important genus in Solanaceae which distribution of some of its species is restricted to Iran and some of the neighboring countries. The main medicinal substances in this plant are alkaloids (tropane alkaloids).One of Hyoscyamus species which has not been analysed yet, is Hyoscyamus insanus.This plant was collected from southern part of Iran and dried in shaddow and after milling was macerated in 96% ethanol. After maceration, total alkaloids were extracted and using successive column and preparative thin layer chomatography, extract fractionated into three parts. The alkaloids is each fraction was identified using Nuclear Magnetic Resonance (NMR) spectroscopy, Mass Spectrometry (MS) and Ultra Violet (UV) spectrophotometry. These three alkaloids were hyoscyamine (atropine), hyoscine and apoatropin. More than 70% of the total alkaloids was hyoscyamine. Regarding this high percentage of hyoscyamin, this species could potentially be used for large scale production.It should be metioned that this is the first report on alkaloid contents of this plant.