جستجوی مقالات مرتبط با کلیدواژه « hyperinsulinemia » در نشریات گروه « پزشکی »

This study aimed to identify a specific dietary pattern related to insulin resistance and hyperinsulinemia in Tehranian adults.

This cross-sectional study was performed on 1063 men and women ≥25 years of age participating in the third phase of the Tehran Lipid and Glucose Study. The dietary pattern was derived by reduced ranking regression (RRR), using 34 food items as predictors and serum insulin concentration and homeostatic model assessment for insulin resistance (HOMA-IR) as response variables. The relationship between a dietary pattern and odds of hyperinsulinemia and insulin resistance (IR) was investigated, and the odds ratio (OR) and 95% confidence interval (CI) were reported.

The mean, standard deviation of age, and BMI of the participants was 43.0±12.2 years and 27.4±4.8 kg/m2. The derived patterns included higher consumption of processed meat, fish, drinkable yogurt, lemon juice, pickles, leafy vegetables, and lower consumption of starchy vegetables, garlic and onions, dried fruits, nuts, red meat, high-fat dairy, and coffee. After adjustment for potential confounding variables, a higher adherence to this pattern was associated with increased odds of hyperinsulinemia (OR=1.69, 95%CI=1.17-1.23, Ptrend=0.005) and IR (OR=2.97, 95%CI=1.66-5.32, Ptrend <0.001).

In this study, an RRR-derived dietary pattern related to serum insulin and HOMA-IR was associated with a higher odds of hyperinsulinemia and IR.

Polycystic ovary syndrome (PCOS), with a prevalence of 4-12 percent, is the most common endocrine-metabolic disorder in reproductive age of women. Reproductive disorders in women with PCO include hyperinsulinemia, hyperandrogenism, chronic anovulation, and infertility. The purpose of this paper was to review and confirm the important role of oxidative stress in creating insulin resistance in this syndrome.

All relevant information was collected through databases such as PubMed and Google Scholar, which was extracted from a total of 100 articles between 1989-2020. Today, the assessment of oxidative stress in women with PCO is performed using circulatory markers such as malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX).

Insulin resistance can be associated with the conditions of oxidative stress in women with PCO. Therefore, obtaining oxidative stress index can be considered valuable, and represent the occurrence of metabolic disorders in this syndrome.

Oxidative stress can play a key role in insulin resistance. Therefore, the oxidative stress index can help to understand unknown metabolic causes of this syndrome.

Polycystic ovary syndrome (PCOS) is the most common endocrine disease and associated with insulin resistance. CXC Ligand 5 (CXCL5) is a new cytokine which is secreted from white adipose tissue during obesity and by blocking insulin signaling pathway inhibits the activity of insulin and promotes insulin resistance.

The aim of this study was to assess serum level of CXCL5 in PCOS women with normal body mass index.

In this case-control study, 30 PCOS women with normal body mass index as the case group and 30 non-PCOS women as the controls were enrolled. Serum levels of CXCL5, insulin and other hormones factors related with PCOS were measured by ELISA method, also the biochemical parameters were measured by autoanalyzer.

Significant increases in serum insulin concentration, homeostasis model assessments of insulin resistance, luteinizing hormone, luteinizing hormone/follicle-stimulating hormone, fasting blood sugar, testosterone, and prolactin were observed in the case group compared to the controls. were in the serum level of CXCL5, cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol,dehydroepiandrosterone-sulfate, creatinine, and homeostasis model assessment of beta cell function between these two groups.

In this study, no significant change was observed in serum concentrations of CXCL5 in PCOS women with normal BMI.

Marked metabolic derangement have already been documented in normal pregnancy such as decrease of serum glucose and aminoacids, increase free fatty acids, triglyceride, ketons and insulin secretion, however in gestational diabetes the high gluc(Jse which is facilitated by placental transfer may cause hyperinsulinemia in fetus thus rendering them susceptible to macrosomia and subsequent perinatal difficulties.
We prospectively followed 117 patients from first trimester period. These patients randomly divided into two groups: Group one (59 cases) was placed on specific diet and Second group (58 cases) received monitored diet plus insulin.
Then we measured maternal weight gains, neonatal birth weights, meteme! fasting and postprandial blood sugar at specific intervals, Initial first trimester maternal weights, gained weights and birth weights were 67.03±3.60 kg and 15.76±3.58 kg and 4.26±0.29 kg for the first group and 65.82±5.25 and 12.68±4.78kg~nd 3.48±0.78 kg for the second group. In 60 normal pregnants these measurement was 56.79±5.41 kg and 12.43±3.20 kg and 3.35±0.36 kg Cesarean section indicated in 71.18 % and 26.2% and 21.66% in two management and control groups respectively (P