جستجوی مقالات مرتبط با کلیدواژه "hypertrichosis" در نشریات گروه "پزشکی"

Acquired local hypertrichosis occurs unilaterally in the same organ, causing asymmetry and beauty-related issues. This study investigates the prevalence of hypertrichosis after the casting of limb fractures, addressing patient concerns, preventive measures, and timely treatment.

In this prospective cohort study, 82 patients who were hospitalized in the orthopedic department of Hazrat Rasul Akram educational, research and treatment complex in 2019 and required limb casting due to fractures or trauma were included. Demographic and clinical information of the patients were collected through interviews or by consulting the patient’s clinical file. The severity of the trauma and the presence of hypertrichosis were also determined by clinical examination.

Out of a total of 82 participants in the study, 41(50%) were male and 41(50%) were female. The mean age was 41.04±22.14 years. The mean duration of casting was 4.65±1.02 weeks. Meanwhile, 80(97.6%) people had undergone plaster casting once; however, 43 people (52.4%) had minor fractures. The most commonly injured site was the distal tibia, accounting for 30.48% of cases. The patients with hypertrichosis and patients without hypertrichosis were the two study groups, and the mean age in each group was significantly different from the other (P=0.0001); however, no other significant relationships or differences were discovered (P>0.05).

The incidence of hypertrichosis in Iranian society is 8.5%, which is slightly lower compared to other societies. Younger patients in Iran are more susceptible to developing hypertrichosis after limb casting of broken limbs.

H syndrome is an autosomal recessive genodermatosis with reports dating back to the last decade. This syndrome is caused by mutations in the SCL29A3 gene. The clinical characteristics of this syndrome consist of dermatological manifestations, including hyperpigmented, hypertrichotic, and indurated patches and plaques. It affects various systems by causing heart anomalies, hepatosplenomegaly, hypogonadism, and low height. This is the case of a 19-year-old girl from the northwest of Iran who was born of a cousin marriage. The primary manifestations included low height, underdeveloped secondary sex characteristics, and typical dermatological manifestations. This patient was examined mostly because of digestive and endocrine problems and thus had not been subject to extensive dermatological examinations until the skin biopsies mirrored manifestations similar to histiocytoses (e.g., Rosai-Dorfman disease and granuloma annulare). The patient was eventually diagnosed with H syndrome by a dermatologist from the clinical symptoms. H syndrome is an autosomal recessive genodermatosis that affects different organs and is diagnosed by a set of typical and systemic cutaneous symptoms and biopsies. In this patient, an endoscopic examination of the upper gastrointestinal tract was carried out due to reports of anemia. A biopsy of the atrophic duodenum region revealed the existence of coeliac disease. However, the comorbidity of coeliac disease and H syndrome has not been previously reported.

H syndrome (OMIM 612391) is an autosomal recessive disease with some features such as hyperpigmentation, hypertrichosis, heart anomalies, hepatosplenomegaly, hearing deficit, hypogonadism, short stature, flexion contracture of fingers and toes and hypertriglyceridemia..
A 17-year-old boy with hyperpigmented, hypertrichotic and indurated seborrheic keratosis-like cutaneous patches mainly involving the extremities referred to Namazi hospital, an academic center affiliated to Shiraz university of medical sciences. The patient belonged to a consanguineous family with Arab origin..
We described a case with many clinical manifestations of H syndrome in addition to new characteristics such as microphallus. H syndrome should be considered in individuals with a constellation of symptoms as hyperpigmentation, hypertrichosis, heart anomalies, hepatosplenomegaly, hearing deficit, hypogonadism, short stature, flexion contracture of fingers and toes and hypertriglyceridemia..