جستجوی مقالات مرتبط با کلیدواژه "il4" در نشریات گروه "پزشکی"

Exercise has effects on changing cancer factors, yet the effect of exercise on the levels of cancer factors in inflicted animals or humans has not been seriously paid attention to. Thus the aim of this study is to study the effect of aerobic continuous training on tumor volume on mice with carcinoma. In this study, 30 female balb/c mice were selected and after transplanting adenocarcinoma tumor in peritoneal area, the mice were randomly divided into a tumor-control and interval training-tumor groups. Interval training protocol was done for 7 weeks at 20% vo2max in the first week and 75% vo2max in the last week. Speleenectomy where doneafter interval training protocol, and Eliza method used to measure Heat Shock Protein 70 (HSP70), Interleukin 4 (IL4) and Interferon γ (IFNγ). The results of this study showed a decrease in the amount of Hsp70 in interval training group but the difference between the two groups was not significant (P>0.05). The results also showed a decrease in the levels of IL4 in the interval training-tumor group but there was no significant difference between the groups (P>0.05). The levels of IFN in interval training-tumor group were higher than those of the control group but this difference was not significant either (P>0.05). However, tumor mass in interval training-tumor group significantly decreased (P=0.001). Based on the results of this research, it can be concluded that doing interval training through changing the amount of effective factors on cancer can lead to a decrease in volume mass.

Shark cartilage is one of the complementary medicines for cancer patients that inhibits tumor progression by several mechanisms. There is not sufficient evidence on its effects on human immune system thereby we investigated its modulatory effects on some cellular immune response parameters in breast cancer patients. After preparation of shark cartilage powder and its distribution in capsules, drug packages were coded. Test group patients consumed shark cartilage and control group consumed starch capsules according to the specified protocol, along with hormone therapy. Blood samples were taken before and after treatment. After isolating and culturing mononuclear cells, the quantity of IL4, IFNγ, as well as CD4+T/CD8+T percentage and ratio were evaluated by ELISA, and Flow cytometry techniques. After treatment, there was a significant increase in the quantity of IFNγ, lymphocyte proliferation and CD4T/CD8T ratio in test group patients, while there was not a significant change in these parameters in control group. It seems that shark cartilage could help strengthen cellular immunity which is important in tumor regression in breast cancer patients. So we suppose that it could be a good candidate for cancer treatment along with conventional medicine.