جستجوی مقالات مرتبط با کلیدواژه "immunotoxins" در نشریات گروه "پزشکی"

Cancer remains one of humanity's leading causes of both illness and death globally. In women worldwide, breast cancer remains the most widespread malignant condition. The new possibilities for direct treatment offered by the advances made thereby were the subject of the recent study undertaken as it sought to unravel tumorigenesis through genetics and molecular appreciation of cancer. Specifically, this research centers on devising and testing immunotoxins as anti-bacterial toxin-based constructs to treat breast cancer. These immunotoxins can kill cancer cells selectively while leaving normal tissues unharmed as they bind only to cancer cell antigens by using both the specificity of antibodies and bacterial toxins' cytotoxicity power. We assessed immunotoxins' binding affinities to their respective antigens based on computational dockings like HADDOCK explaining encouraging results characterized by good docking scores accompanied by low RMSDs—also, dual targeting approaches combined with structure-based. By developing humanized antibodies and novel targeting moieties, challenges such as immunogenicity and non-specific toxicity have been tackled. Our findings suggest that optimized immunotoxins have great potential to enhance therapeutic window as well as efficacy in cancer treatments

Cancer is known as one of the most common causes of death in the world and the number of patients is increasing every year. Cancer is a major cause of death in the world.

Due to the problems of using conventional methods of chemotherapy and radiation therapy, including the resistance of cancer cells to some chemotherapy drugs and having side effects and toxicity of these drugs on healthy tissues, it seems necessary to provide new solutions for specific and more effective cancer treatment. Immune glubloin-based treatments have become particularly crucial in the treatment of cancer. Today, the use of recombinant proteins that can track, identify and destroy specific tissues and cells is of interest to researchers.

The result of the research was the discovery of a type of intelligent hybrid proteins called immunotoxins.

In this study we provided a review of the biological and clinical applications of immunotoxins in treatment of cancer. immunotoxins indicated that can act against cancer tissues. Immunotoxins might be effective in removing circulating tumor cells with large amounts of antigens.