جستجوی مقالات مرتبط با کلیدواژه "inflammatory drugs" در نشریات گروه "پزشکی"

Ibuprofen (IBU) is one of the most consumed nonsteroidal anti-inflammatory drugs (NSAIDs) widely used in musculoskeletal and analgesic treatments. This study set out with the aim of assessing the efficiency of conventional ozonation process in a semi-batch plug-flow reactor in order to remove IBU from aqueous solutions.
A laboratory scale semi-batch plug-flow ozonation reactor was employed during the present study. Four variables including pH, dosage of ozone, hydraulic retention time (HRT), and initial Ibuprofen concentration, which might affect the degradation of Ibuprofen, were taken into consideration. The IBU concentration was determined using HPLC.
Working under optimal operating conditions (pH = 8, HRT = 60 min, C=5 mg/L and Ozone dose 2/5 g/h), about 59% IBU degradation was noticed. Results also revealed that the degradation of IBU well fitted with the firstorder kinetics.
The operating variables of pH, dosage of ozone, initial Ibuprofen concentration, and HRT were optimized using a plug-flow reactor to improve contact between dissolved ozone and the drug. pH and HRT were the most affecting variables. Furthermore, a predictive model allowing us to predict the percentage of IBP degradation
as a function of pH and HRT under experimental conditions was obtained.

Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs commonly prescribed in dental practice for the management of pain and swelling. But, rarely hypersensitivity reactions are reported.
Case Report: A 28 year old woman underwent periodontal plastic surgery (gingival graft). Postoperative analgesics (400 mg Gelofen ,oral) and antibiotics were administrated for the patient. Three hours after discharge of patient, she complained of redness, itching , rapid swelling of her eyes in 10 minutes, and watery eye discharge 1 hour after taking the drugs. She was treated with 8mg/2ml mg Dexamethasone IM at the dental department and with Hydrocortisone 100mg/ml IM and antihistamine drugs at the hospital.
There are no published protocols and sensitivity and specifity of skin pick testing and patch testing for Gelofen. So avoidance of re-exposure is the best management strategy. The use of Cox-2 specific medications would be a proper alternative for pain relief.

Inflammation is as a beneficial response to injury on the other hand, inflammation is accounted as complex immune systems of the host against agents biologic, chemical and physical. Chronic inflammation that was produced by genetic mutations, autoimmune diseases and environments factors can increase risk of cancer. Epidemiologic studies have shown more than 25% of dead cause of cancer was inflammation. Although, today it is believed that inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury and that the basic signs of inflammation can be explained by pain, increased blood flow, red and swelling. Acute inflammation can be produced in which under normal conditions is considered as immune reaction, if it converted to chronic inflammation can be led to cancer, CVD, lung and nervous diseases. The aim of the present minireview was to examine the evidence about inflammation and its correlation with cancer.

Background and Cyclooxygenase II enzyme is one of the most important enzymes of prostaglandin synthesis pathway that also causes inflammations in human body. In the present study, the anti-inflammatory activity of eight new synthesized compounds with COX II inhibitory potential was evaluated in carrageenan induced paw edema in mice. Different doses of the compounds (10, 25 and 50 mg/kg), celecoxib (positive control, 10 mg/kg) and normal saline-tween (negative control) were intraperitoneally administered to the mice (female, 25-30 g, n=6). After 30 min, carrageenan was injected subcutaneously into the subplantar tissue of the left paw in all groups. The volume of paw was measured in different treatment groups at 0, 1, 3 and 5 hours following the carrageenan injection and percentage changes of paw volume was calculated. Data were reported as Mean ± SD. T-test was used to compare the results and P < 0.05 was considered significant. At the 10 mg/kg dose, all compounds showed significant anti-inflammatory activity just in 1st hour. At the 25 mg/kg dose, some compounds had significant anti-inflammatory activity in all investigated times, and at 50 mg/kg dose, all compounds showed significant anti-inflammatory activity in 1st, 3rd and 5th hour compared to the group injected with normal saline- tween. This study found 4-(4-Methylsulfonylphenyl)-3-phenyl-2(3H)-thiazole thione derivatives with good anti-inflammatory activities.

Postoperative pain following root canal therapy in of concern for the patient and dentist. Despite the fact that the pain relief afforded by endodontic treatment is effective، it is rarely immediate and complete. The purpose of this study was to compare the efficacy of amitriptyline with ibuprofen in controlling of post-endodontic pain. This randomized double-blind placebo controlled clinical trial included 75 patients with symptomatic vital molar which presented with moderate to severe endodontic pain. Patients were randomly allocated in one of 3 groups to receive uniform capsules containing placebo، ibuprofen 600mg or amitriptyline 50mg as single dose 90 min before root canal treatment. Pain intensity was recorded in Visual Analogue Scale (VAS) chart in defined times before، during and after treatment by patients. Data was statistically analyzed by Repeated Measures ANOVA and Tukey test. Statistically significant differences in mean pain score was seen between ibuprofen and amitriptyline groups with placebo group during، and 12، 18، 24، 36، 48 hours after treatment; but the difference was not significant at 6، 60، 72 hours after treatment. The difference between amitriptyline group and ibuprofen group was not statistically significant at any time. The results showed that amitriptyline administration is as effective as ibuprofen in management of post-endodontic pain in patients presented with moderate to severe pain.

Background and Nonsteroidal anti-inflammatory drugs (NSAIDs) remain among the most widely prescribed drugs worldwide for the treatment of inflammation including pain-releasing, anti-pyretic and rheumatoid arthritis. The conventional NSAIDs exert their effects by inhibiting cyclooxygenase (COX) enzymes. Subsequent research and rational drug design validated the initial concept that a selective COX-2 inhibitor would illicit effective anti-inflammatory without the adverse ulcerogenic effect associated with the use of NSAIDs that inhibit both COX-1 and COX-2. Accordingly, in this work we report the synthesis of a new diaryl heterocyclic series, the 3,4-diaryl-4-thiazoline-2-thione, as potential selective COX-2 inhibitors. The starting material thioanisole underwent Friedel-Craft reaction with acetic acid in the presence of trifluoroacetic anhydride followed by oxidation by MCPBA to give 4-(methylsulfonyl) acetophenone. This compound was then treated with Br2 in CHCl3 to give phenacyl bromide derivative. On the other hand, condensation of aniline derivatives with carbon disulfide in the presence of triethylamine gave the corresponding dithiocarbamate salt. Subsequently, reaction of aryl dithiocarbamate with methylsulfonyl phenacyl bromide furnished cyclic alcohol intermediate, which was dehydrated by 80% H2SO4 to give 3,4-diaryl-4-thiazoline-2-thione. All of the target compounds were characterized by their 1H-NMR, 13C-NMR, IR and mass spectral data. In view of the pharmacological importance of the selective COX-2 inhibitors, a series of 3,4-diaryl-4-thiazoline-2-thiones having pharmacophoric features of COX-2 inhibitors have been synthesized via convenient and efficient synthetic pathway, and structurally characterized by different spectroscopic methods.

In this case report we introduce 9 years old boy who had suffered recurrent bone infections including the sternum, clavicles, navicular bone, distal radius and proximal tibia since the age of 5. In every instance the diagnosis of infectious ostemyelitis was made and antibiotic therapy was instituted to which the patient did not respond. More over all the cultures taken from the affected sites were negative for bacteria, fungi and mycobacteria, and all the immunological tests which were based on the probable diagnosis of chronic granulomatous disease or other immune deficiencies proved to be negative. After being diagnosed as a case of CRMO treatment with NSAIDs successfully controlled the disease process. In 7 months follow up no new exacerbation was noted.