جستجوی مقالات مرتبط با کلیدواژه « insulin-like growth factor 1 » در نشریات گروه « پزشکی »

Neurotrophins play a key role in the survival and growth of neurons; They are also important in the processes of synaptic plasticity, memory enhancement and learning processes; Therefore, the purpose of the current research is the effect of chronic football training on two neurotrophic factors of brain tissue in neurocognitive function and their relationship to the state of physical fitness in growing adolescent boys.

The current study was a semi-experimental type, in the from pre-test-post-test. A total of 40 growing adolescent boys aged 14 to 15 years were randomly assigned to four groups: 1-Football Training+Perceptual Motor Training (FT+PMT), 2-Football Training (FT), 3-Perceptual Motor Training (PMT) and Control (CO) were divided (10 people in each group). Football training and perceptual motor training were for eight weeks (three training sessions per week). Data analysis was done through analysis of covariance and post-hoc Bonferroni's tests in SPSS version 29 software. The significance level was P≤0.05.

A significant increase in the plasma levels of NGF, BDNF and IGF-1 was observed (p≤0.05). This significant increase was more significant in FT+PMT and FT groups than other groups (p≤0.05). On the other hand, a significant decrease in Stroop test errors was observed in FT+PMT, FT and PMT groups (p≤0.05).

It seems that increasing the levels of NGF, BDNF and IGF-1 through football and perceptual motor training leads to improvement in the cognitive functions of developing adolescents.

Different training methods have cardioprotective effects. The aim of this study was to examine the potential protective impact of continuous and interval swimming training with weights on cardiac morphological factors and serum levels of Apelin and Insulin-like Growth Factor-1 in male Wistar rats.

In this experimental study, 27 male rats divided randomly into the control (n=6), sham (n=5), interval (n=8) and endurance (n=8) groups. The endurance group swam for 12 weeks/5 days while swimming time increased incrementally. During the 12-week/4-day period, the interval group engaged in swimming exercises while gradually increasing the load and reducing the duration of rest. Apelin and Insulin like Growth Factor-1 concentration, heart weight and left ventricle weight were measured. One-way ANOVA was utilized and Tuckey-HSD test was used to point out the place of significance (α ≤ 0.05).

Findings showed that total heart weight in interval and endurance training compared to the control (P= 0.02 and P= 0.02 respectively) and sham (P= 0.02 and P= 0.02, respectively) significantly increased. Furthermore, the weight of the left ventricle showed a significant increase following endurance training in comparison to both the control (P= 0.02) and the sham groups (P= 0.02). Additionally, it was found to be significantly higher than the sham group following interval training. (P= 0.01). Apelin significantly increased in interval and endurance training compared to the control (P= 0.00 and P= 002 respectively) and sham groups (P= 0.02 and P= 0.04, respectively). Moreover, insulin like growth factor-1 significantly increased in interval and endurance training compared to the control (P= 0.01 and P= 0.01, respectively).

It appears that a 12-week swimming training program, particularly in an interval format, can induce physiological hypertrophy in cardiac tissue and provide cardiac protective benefits through the upregulation of Insulin-like Growth Factor-1 and Apelin.  

Diabetes is associated with an increase in inflammatory markers and developmentof atrophy and cardiovascular diseases. Studies have shown that resistance training at appropriateintensity can reduce inflammation generally. This study aims to investigate the effect of a progressiveresistance training (PRT) program on serum concentrations of interferon gamma (IFN-γ), and insulin-likegrowth factor 1 (IGF-1) and lipid profile in rats with type 1 diabetes.

In this experimental study, 32 male Wistar rats aged 40 days and weighing 250±30g were divided into four groups of healthy control, healthy trained, diabetic control, diabetic trained.Streptozotocin (55 μg/kg per body weight) was injected intraperitoneally to induce diabetes. A 6-weekPRT protocol was performed, including climbing a ladder with weights at three sessions per week (onehour per day), where the load increased by 5% increase each week. Data were analyzed by ANOVA followedby Tukey’s post hoc test. The significance level was set at 0.05.

There was no significant difference in IFN-γ level between the diabetic trained group andother groups (P>0.05). The IGF-1 level in diabetic trained group was significantly lower than in thehealthy control and trained control groups (P=0.002). The ratio of IGF-1/IFN-γ in diabetic trainedgroup was significantly lower than in the trained control (P=0.003) and healthy control (P=0.008)groups. In assessing the lipid profile, the cholesterol level was higher in the diabetic trained groupcompared to the healthy control group (P=0.028). Moreover, triglyceride level was significantlyhigher in the diabetic trained group compared to the diabetic control (P=0.033), trained control(P=0.003) and healthy control (P=0.002) groups.

Six weeks of PRT cannot lead to desired efficacy in diabetic rats compared to non-traineddiabetic rats. However, the small changes such as increased IGF-1 and HDL levels and decreased serumglucose level, can help with the clinical improvement of patients with type 1 diabetes.

Menopause is a natural and inevitable component of women's lives and encompasses physiological, psychological, and social changes, including hot flashes, depression, muscle aches, inflammation, osteoporosis, and weight gain. Using herbal dietary supplements is an attractive approach to controlling obesity and associated complications. Therefore, this study aimed to investigate the effect of eight weeks of exercises in the water along with oleaster supplementation on C-reactive protein (CRP) and insulin-like growth factor-1 (IGF-1) in overweight and obese postmenopausal women.

Forty-two postmenopausal women with a mean age of 52.97± 5.08, mean weight 73.95± 8.09 kg and mean height 156.057±7.56 Cm randomly divided into four groups: control (n=10), exercise+ placebo (n=10), supplement (n=10), and exercise+ supplement (n=12). The exercise+ placebo group conducted eight weeks of water exercise with an intensity of 60-74% of maximum heart rate twice a week, the supplement group received daily supplementation of 15 g daily, the exercise+ supplement group eight weeks both used supplements and exercised in water and the control group did not undergo any exercise or supplements during eight weeks. Blood samples were collected from subjects in two stages to evaluate the variables under fasting conditions. CRP and IGF-1 concentrations in serum were measured using an ELISA kit and mass spectrometry, respectively.

The results revealed a significant difference in C-reactive protein within the exercise+ supplement and supplement groups. Besides, there was a significant difference in insulin-like factor-1 among the three experimental groups (P<0.05).

The use of oleaster supplements and exercise in water has not been able to affect growth and inflammatory factors, so continuously taking oleaster supplements is not recommended for overweight postmenopausal women.

This study aimed to the effect of insulin-like growth factor-1 on the proliferation of goat spermatogonial stem cells (SSCs) in vitro.

The testicles of immature goats were obtained from slaughterhouse. Isolation of spermatogonial cells was performed by two-step digestion. The isolated cells were cultured in 4 different groups: 3 groups by adding different doses of IGF-1 (10, 40 and 100 ng/ml) to the basic medium (DMEM containing 5% fetal bovine serum and 1% antibiotic) and the control group (without IGF-1). Data were analyzed by one-way ANOVA and Tukey test at 5% level. Presence of SSCs at the end of culture was determined by reverse transcription polymerase chain reaction (RT-PCR) for several important spermatogonial markers (PGP9.5, THY-1, PLZF, Oct4 and VASA) and immunohistochemical staining against PGP9.5 antigen.

In this study, the number of spermatogonial cell colonies in treatment 3 was significantly higher than the control and other treatment groups on days 4, 7, and 10 of culture (P<0.05). Also, the surface area of G10 colonies on days 7 and 10 of culture was significantly different (P<0.05). The surface area of G100 on days 4, 7, and 10 after culture was significantly higher than control, G10 and G40 (P<0.05). The isolated cells expressed all surface markers related to stem cells.

According to this results, the addition of 100 ng/ml IGF-1 to culture medium for promoting colonization of goat Spermatogonial stem cells is recommended.

Besides a source of energy storage, adipose tissue acts as an endogenous tissue and plays an important role in maintaining the balance of the body's metabolism through secreting specific hormones and cytokines. The aim of this study was to evaluate the effect of date palm pollen extract and resistance training on adipose tissue metabolism and expression of secretory factors in male rats.

This experimental study was conducted on control and test groups. Thirty male Sprago-Dawley rats were divided into 6 groups of: control, resistance training, date pollen extract treatment, testosterone treatment, date pollen extract treatment + resistance training, testosterone treatment + resistance training. Date pollen extract was prepared and fed to rats at a dose of 100 mg/kg for four weeks. Testosterone enanthate at a dose of 2 mg/kg was injected into the target groups every day. The resistance training protocol, including ladder climbing with weights equivalent to 65% of the body weight of rats was performed for four weeks. Histopathological assessments were performed by H&E staining and the expression levels of leptin and IGF-1 genes were evaluated by real-time PCR. The resulting data were statistically analyzed using one-way ANOVA and Tukey's tests at a significance of p<0.05.

The results showed that taking date pollen extract and doing resistance exercises at the same time caused a significant decrease in leptin gene expression (p<0.05). Also, treatment with testosterone + resistance training led to a significant decrease in the expression of IGF-1 (p<0.05) and leptin (p<0.05) genes.

It could be concluded that resistance training combined with treatment with date pollen extract may be effective in the reduction of IGF-1 and Leptin gene expression as well as decrease in the number of adipocytes in the adipose tissue.

Endurance training effectively reduces growth hormone levels in obese children and adolescents more than resistance training. However, the effects of these exercises on non-obese children and teenagers are in an aura of ambiguity. The present study was conducted with the aim of determining the effects of endurance training on growth factor and insulin-like growth factor-1 in children and adolescents in the form of a systematic review and meta-analysis.

The current study is a systematic review and meta-analysis (based on the PRISMA statement). Articles published till the beginning of 2022 were searched in PubMed, Web of Science and EBSCO, CINAHL, MEDLINE, SPORTDiscus), Scopus, Mag Iran and SID databases. Search strategy was done with the help of Boolean operators with the keywords (young people or children or adolescents or teenagers or boys or girls or minors) and (hormone or growth hormone or insulin-like growth factor-1 or endocrine glands or cytokine) and (exercise or training) and (endurance or resistance).

The results of this meta-analysis showed that endurance exercise training is not associated with a significant increase in the amount of growth hormone at the end of the study compared to the beginning of the study (Means difference: 48 ng/ml, (0.02-0.99: CI95%, I2=0%, P=0.06). Also, the results of the meta-analysis in the other part of the results indicated that endurance exercise does not lead to a significant change in insulin-like growth factor-1 at the end of the study compared to the beginning of the study (The difference in means was 22.90 ng/ml, (2.12-47.92: CI95%, I=0%, P=0.92).

Endurance training has no effect on growth hormone and insulin-like growth factor-1 in non-diseased children and adolescents.

Insulin-like growth factor -1 (IGF-1) has a variety of roles, but the abundance of scientific evidence indicates that it is a metabolic biomarker associated with physical fitness and health. The present study investigates the effect of eight weeks of polarized exercise training on serum GH / IGF-1- indices in active young men.

In this double-blind experimental study, 20 young males were allocated randomly into polarized training group (N=10) and a control group (N=10). The polarized training group performed 80-70% of the main workout volume (30 minutes) with light to moderate with 50-60% reserve heart rate (RHR) intensity and the remaining 20-30% at 85-95% RHR intensity; in a way that they ran two periods consisting 3 repetitions of 15-30 seconds, with 30-60 seconds of active rest after each repetition and 3 minutes of active rest after each period. Blood samples were taken from all subjects in three stages, including: pre-test stages, 24 hours before the start of the post-test, and after 12 hours overnight fasting. Post-test samples were collected, one sample immediately after the first session and the another 48 hours after the end of the last exercise session.

The results of the present study showed that bipolar training significantly increased growth hormone and free IGF-I levels after one training session, and after eight-week bipolar training program. However, total IGF-1 levels decreased significantly after one exercise session and after eight-week bipolar exercise program. Also, no significant change was observed in IGFBP-3 and IGFBP-5 levels after one training session and eight-week training program. Acid-labile subunit levels did not change significantly after one training session, but decreased significantly after eight weeks of bipolar training.

Based on the results of the present study, it seems that the use of bipolar exercises, training may be a good way to improve the hormonal function and assess the level of health and physical fitness of active young men.

Idiopathic short stature is a common cause for referral to children's endocrinology clinics. Despite the normal level of growth hormone, the level of insulin-like growth factor 1 (IGF-1) is low in some of these individuals, which is not well-defined. The aim of this study was to determine the effect of vitamin D on the level of IGF-1 in children aged 5 to 10 years with idiopathic stunting.

In a clinical trial study, 30 children aged 5-10 years with the diagnosis of idiopathic short stature were selected, and treated with 50000 vitamin D3 supplements every week for 8 weeks. Serum levels of vitamin D and IGF-1 were measured before and after intervention and compared.

Before and after intervention, mean serum levels of vitamin D were 17.03 ± 6.8 and 44.4 ± 9.2 ng/ml (P < 0.001), and mean serum level of IGF-1 were 17.9 ± 81.5 and 124.4 ± 37.4 ng/ml (P < 0.001), respectively. The level of IGF-1 significantly increased by vitamin D supplementation.

The present study showed that improvement of vitamin D deficiency led to increased level of IGF-1. It seems that in children with idiopathic short stature, the elimination of vitamin D deficiency can be effective in increased level of IGF-1.

Fibroblasts are involved in production of growth factors which are effective on cells’ growth and differentiation. They are the most adaptable cells in connective tissue with significant capacity for differentiation to the other cell group. Insulin-like growth factor-1 (IGF-1) plays an important role in differentiation and growth of different cell lines. Silibinin is extracted from seeds of Silybum marianum, which it's effects in cancer cell lines, have been studied in limited studies. In this study we evaluated the silibinin effect on viability and IGF-1 gene expression in human foreskin fibroblast (HFF).

The cytotoxic effect of 10, 20, 40 & 60 µM solution of silibinin was evaluated on HFF cells using MTT assay, after 24 & 48 hours. Then, the expression of IGF-1 gene was evaluated by means of real time-PCR.

Silibinin had toxic effect on HFF cells in dose-dependent manner after 24 hours of incubation in comparison with control group but no significant difference observed after 48 hours. Besides, after 24 hours of incubation, silibinin with a concentration of 20-40-60 µM significantly increased the IGF-1 gene expression in fibroblast cells in comparison with control group.

Based on the results, silibinin significantly induces IGF-1 gene expression in dose dependent manner after 24 hours incubation with HFF cells. However, in cytotoxicity assay, concentration of 60 µM caused the highest rate of cell death after 24 hours. So, before introduction of this compound as a fibroblasts proliferation stimulant, more extensive studies are needed.

Overweight and osteoporosis are two common health problems in adults that often result from decreased physical activity. Biochemical markers evaluate the effects of dynamic changes on bone function and determine the response of bone metabolism to physical activity. Insulin-like growth factor-1, parathyroid hormone and alkaline phosphatase are important bone markers in bone metabolism, but there is still much ambiguity about them. The purpose of this study was to evaluate the effect of three months basketball training on Insulin-like growth factor-1, parathyroid hormone and alkaline phosphatase in 45-55 years old overweight men.

24 overweight men (47.91±2.06 years, 27.80±1.13 kg/m2) were purposefully selected based on inclusion criteria and randomly divided into control and experimental groups. The experimental group practiced basketball training three days a week, 90 min in each session, for three months. 24 h before training and 48 h after the last training session, the fasting blood sample was taken to measure insulin-like growth factor-1, parathyroid hormone and alkaline phosphatase by ELISA method.

Insulin-like growth factor-1 (P=0.002) and alkaline phosphatase (P=0.03) were increased after three months basketball training. However, parathyroid hormone was not changed significantly.

It seems that three months basketball training can induce mechanical loading effects on musculoskeletal tissue and has anabolic effect on the body