جستجوی مقالات مرتبط با کلیدواژه « intercellular adhesion molecule-1 » در نشریات گروه « پزشکی »

Aging is often accompanied by inflammation and lipid abnormalities. This study aimed at investigating the effects of endurance training combined with Citrus aurantium L.var. amara Engl. (CAVAO) consumption on the lipid profile, intercellular adhesion molecules-1 (ICAM-1), and vascular cell adhesion molecules-1 (VCAM-1) in aged Sprague-Dawley rats.

In this experimental study, 35 aged Sprague-Dawley rats were divided into 7 groups: high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), HIIT with CAVAO (HIIT+CA), MICT with CAVAO (MICT+CA), CAVAO alone (CA) (300 mg/kg/day), control, and sham. Over eight weeks, HIIT was conducted at 85-110% VO2max intensity, while MICT was performed at 65-75% VO2max intensity. Lipid profiles were assessed using a kit, and ICAM-1 and VCAM-1 gene expressions were analyzed via RT-PCR.

HIIT, MICT, HIIT+CA, MICT+CA, and CA resulted in a significant increase in HDL levels, with HIIT showing the most pronounced effect (P<0.05). LDL decreased significantly in all groups except CA (P<0.05). The HIIT+CA group exhibited a greater reduction in TG levels compared to the CA group. Cholesterol levels decreased in the HIIT, MICT+CA, and CA groups, with the CA group demonstrating a more substantial reduction than the HIIT and MICT+CA groups (P<0.05). VCAM-1 levels increased in all groups, while ICAM-1 levels decreased in all groups except HIIT+CA, where a more significant reduction in ICAM-1 was observed compared to other groups (P<0.05).

The combination of endurance training interventions and CAVAO antioxidant supplementation (HIIT, MICT, HIIT+CA, MICT+CA, CA) may offer cardiac protection against hyperlipidemia due to their antihyperlipidemic effects. The interactive effect of HIIT+CA and MICT+CA appears to have a more favorable impact on lipid profiles and ICAM-1 levels.

Obesity by expansion of adipose tissue and changing its secretory profile has undesirable effects on the other body tissues. However, different types of exercise training because of their role for improving lipid metabolism, considered as an effective strategy to combat obesity. Accordingly, changes in the plasma levels of WISP-1, ICAM-1, and VCAM-1 after 12 weeks high intensity interval training (HIIT) and moderate intensity continuous training (MICT) in women with type 2 diabetes were investigated in the present study. In this study, 36 type-2 diabetic women with an age of 46.95±3.49 years participated in this study, which randomly assigned into three groups including HIIT, MICT and control groups. The exercise training program conducted as HIIT (90% maximum heart rate) and MICT (60-70% maximum heart rate) for 12 weeks and three sessions per week. For measurement of variables, blood sampling conducted before and after (48 hours after the last training session) 12 weeks of exercise training in fasting state. For data analysis, analysis of covariance test along with Bonferroni's post hoc test were used. According to present findings, WISP-1 levels reduction was significant in HIIT (p<0.001) and MICT (p=0.007) groups. ICAM-1 levels also showed a significant decrease in HIIT (p<0.001) and MICT (p<0.001) groups. However, the reduction of VCAM-1 levels was significant only in the HIIT group (p=0.031). These changes were associated with a significant decrease in insulin resistance in HIIT and MICT groups (p<0.001). The present findings showed the positive effects of exercise training (HIIT and MICT) for decreasing inflammatory and cardiovascular risk factors. Because of greater effects observed for HIIT, participating in this type of training program could be very important for obese people.

Adhesion molecules play an important role in the pathogenesis of atherosclerosis and the type of training may affect the response to these indicators. Therefore, the purpose of the present study was to investigate the effect of a continuous versus interval aerobic training session on plasma levels of intercellular adhesion molecules 1 (ICAM-1) and vascular cell adhesion molecules 1 (VCAM-1) in patients with coronary artery disease.

In this quasi-experimental study, 9 women with coronary artery disease participated in pre-test and two stages of post-test design (interval and continuous). Continuing training program included running or walking for 30 minutes with an intensity of 60% of maximum heart rate. Therefore, interval training included 30 minutes of walking or running with variable intensity between 50% and 80% peak heart rate. ICAM-1 and VCAM-1 serum levels were measured in scale of ng/ml by ELISA. Results were analyzed by SPSS Inc., Chicago, IL; version 24 and repeated measures test were used at a significant level of P≤0.05.

One session of continuous and interval training didn’t show significant differences in ICAM-1 and VCAM-1 serum levels. So that the ICAM-1 levels were obtained (233.6 ± 0.1) after continuous training and (230.4 ± 1) after interval training (P= 0.186). In addition, VCAM-1 levels were observed (163.3 ± 7.0) after continuous training and (194.8 ± 6.9) after interval training (P= 0.121).

One session of training stimulates inflammatory pathways in coronary artery disease patients. Based on the results of this study, the effect of continuous aerobic training on the levels of adherent molecules cannot be determined certainty and more research is needed.

The expression of adhesion molecules in the heart tissue is considered as an important indicator in the estimation of coronary artery disease risk. Since physical activity is effective in reducing symptoms of cardiac disease, the purpose of the present study was to investigate the effect of eight weeks of continuous endurance training on ICAM-1 and VCAM-1 expression in the heart tissue of rats.</span>

In this experimental study, 12 eight weeks male Wistar rats with an average weight of 263±12 g were randomly divided into 2 groups: control (n=6) and exercise (n=6) were divided. The training program included 8 weeks of running on a treadmill with a 70 to 75% VO2max intensity (five days a week and 30 minutes each day). The expression of ICAM-1 and VCAM-1 genes were measured by Real-time PCR and compared in two groups.</span>

The results showed that 8 weeks of continuous endurance training reduced the expression of ICAM-1 in the heart tissue. In comparison, there was a significant difference between the control group (0.29±0.05) and training (0.10±0.03) (p=0.017). In addition, it was shown that the expression of VCAM-1 in the heart tissue significantly increased in training group (0.85±0.04) compared to the control group (0.22±0.03) (p=0.001).

The results of this study showed that continuous endurance training altered the expression of adhesion molecules in heart tissue associated with systemic inflammation, which could be a suitable solution for reducing fat deposits in the heart tissue and preventing its harm.