جستجوی مقالات مرتبط با کلیدواژه « ischemia modified albumin » در نشریات گروه « پزشکی »

Carbon monoxide (CO) poisoning is a widespread cause of morbidity and mortality, with delayed neurological Sequelae  (DNS) among the most severe consequences of this silent killer. To study the relationship between neutrophil-lymphocyte ratio (NLR), ischemia-modified albumin (IMA), and severity of acute CO poisoning as well as their role in predicting delayed neurological manifestations.Patients and Sixty acutely CO-intoxicated patients were admitted to Alexandria Poison Center, Egypt. NLR and IMA were assessed. Six months after discharge, all patients were subjected to neuropsychometric testing using Mini-Mental Status Examination (MMSE). Brain magnetic resonance imaging (MRI) was conducted on cognitively impaired patients. NLR was abnormally high in most patients and the mean serum level of IMA was significantly elevated in acutely CO-intoxicated patients compared to the control group (P<0.001). NLR and IMA were significantly related to neurological manifestations and other laboratory parameters. Patients were subdivided into DNS group (n = 16) and non-DNS group (n = 44), according to MMSE and brain MRI done after six months, with significant elevation of NLR and IMA in DNS group (p<0.001). The accuracy of DNS prediction parameters was measured using the area under the receiver operating characteristics curve. Excellent accuracy was detected for IMA and NLR. The studied markers of NLR and IMA assessed on admission could be employed as useful biomarkers for correlating with acute CO poisoning severity and predicting the outcome including the possibility of development of DNS.

The objective of this study was to determine the levels of serum ischemia-modified albumin (IMA), fibrinogen (FIB) and high sensitivity C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) patients with hypertension (HT) (DMT2HTN) and without HT (DMT2). Also, their association with certain biochemical and physical factors were studied to identify possible risk factors that lead to cardiovascular complications.

Fasting blood samples were collected from 35 DMT2 or DMT2HTN patients each to analyze differences in serum and plasma levels of IMA, hs-CRP, FIB, total cholesterol (TC), high and low density lipoproteins (HDL and LDL), triglyceride (TG), hemoglobin A1c (HbA1C), glycated hemoglobin and creatinine.

In DMT2 and DMT2HTN patients, IMA, hs-CRP, FIB, TC, TG, HDL, LDL, glycated hemoglobin and creatinine levels, including body mass index (BMI) and waist-to-hip ratio (WHR), were significantly higher relative to healthy controls. In addition, the levels of IMA, hs-CRP and FIB levels showed a strong link to BMI, WHR, TC, TG, LDL and glycated hemoglobin. Lastly, both DMT2 and DMT2HTN patients demonstrated a significant reduction in HDL.

DMT2 and DMT2HTN patients have a greater risk of developing cardiovascular related complications. This study suggests that quantifying hs-CRP, IMA and FIB levels can help diagnose the risk of developing complications during the early stages of metabolic and cardiovascular disease. Overall, the specific risk factors may be used for early identification of cardiovascular complications to decrease mortality and morbidity in T2DM patients.

We aimed to investigate the potential early diagnostic value of ischemia modified albumin (IMA) and D-dimer in testicular torsion.

A total of 42 prepubertal Wistar-Hannover rats (26-30 days old, weighing 75-125 grams) were used in the study. They were randomly divided into 2 groups as torsion (21 rats) and control (21 rats). Both torsion and control groups were subdivided into three subgroups as 30th, 120th and 240th minutes. Intraperitoneal injection of 70 mg/kg ketamine (Ketalar, Pfizer, Istanbul, Turkey) plus 10 mg/kg of xylazine (Rompun, Bayer, Istanbul, Turkey) were used for general anesthesia. In the control group, scrotal incision was made and the left testis gently extracted. Then, intracardiac blood and testicular tissue were obtained at 30th, 120th and 240th minutes. In torsion group, testicular ischemia was achieved by rotating left testis 720° clockwise and maintained by fixing the testis. Blood and testicular samples were obtained at 30th, 120th and 240th minutes. All animals were sacrificed after completion of the study.

There was a statistically significant difference between the IMA and D-dimer levels at 30th, 120th and 240th minutes of torsion group when compared with the control group (p = .001). When compared in terms of pathological changes at 30th, 120th and 240th minutes, significant difference was found for all 3 periods (p = 0.039, p = 0.014, p = 0.03, respectively). The D-dimer and IMA estimated torsion with reasonable accuracy [Area under the curve (AUC)= 0.771 (p = 0.003, 95% confidental interval: 0.620-0.922) and AUC = 0.706 (95% confidental interval: 0.549-0.863, p = 0.022), respectively.

The elevated D-dimer and IMA serum levels observed in the experimental testicular torsion model seem to have a potential role as a serum marker in the early diagnosis of testicular torsion.

assured diagnosis of heart problems. However, the amount of this factor in response to exercise and in different times of the day is not determined. Therefore, the present study aimed to investigate the effect of training time (morning and evening) on ischemia-modified albumin (IMA) plasma levels in male patients with cardiovascular disease. 15 male patients with cardiovascular disease were chosen to participate in this quasi-experimental study. Before the outset of exercise protocol under specialist supervision, pre-test blood samples were taken from subjects at 7:00 in the morning. After taking blood samples, all participants took part in an exercise test until exhaustion. This test was designed based on Bruce protocol including 7 stages and each of these 3 minute stages followed predetermined speed and grade. One week later, subjects went through the same process at 7:00 in the evening. Paired sample t- test was used to analyze and compare pre-test and post-test means of each training period (morning and evening) and compare the mean of both times in the morning and in the evening. SPSS.20 was used to analyze study data. there is no significant difference between pre-test means during morning and evening exercises (P=0.292). In addition to this, no significant relation was observed between post-test mean and three-hour-after test in the morning and evening, (P=0.185) and (P=0.250), respectively. Based on this study it could be said that circadian rhythm and circadian cycle have no severe effect on chemical responds and cardiac risk factors. Thus, cardiovascular patients can engage in their desired exercise during morning and evening.

Oxidative stress by cardiac ischemia causes protein modifications in serum albumin to create Ischemia Modified Albumin (IMA) and other circulatory proteins to create protein carbonyl (PC), whose increase from the baseline could be used as a diagnostic tool for cardiac ischemia disease. We aimed to evaluate the differentiation of IMA, PC, malondialdehyde (MDA) and total antioxidant capacity (TAC) between patients with early stage non-ST-segment elevation myocardial infarction (NSTEMI) and healthy control subjects and test their sole and integrative recognition efficiency as rapid predictive biomarkers for NSTEMI. We selected 52 patients of both sexes with the diagnosis of NSTEMI within 6 hours. Fifty-two healthy individuals without significant differences in sex and age having normal cardiac troponin I (cTnI) levels were enrolled as control group. Serum samples were collected and IMA, PC, MDA, and TAC levels were quantified and then, their findings were compared with serum cTnI levels as the "gold standard". Linear regression, correlation, and receiver operating characteristic (ROC) curve analyses showed that both circulatory levels of PC and IMA were statistically elevated in NSTEMI patients compared to control group, and both had statistically high sensitivity and specificity for rapid prediction of NSTEMI. Combinatorial determination of both biomarkers increased the test specificity and negative predictive value (NPV). Both PC and IMA contents could be used as early biomarkers for diagnosis of NSTEMI and integrative determination of both biomarkers could be used in emergency departments for the fast diagnosis of NSTEMI.