جستجوی مقالات مرتبط با کلیدواژه "lassa virus" در نشریات گروه "پزشکی"

The spread of Lassa Fever (LF) cases across international borders call for cross-board management and collaboration. This case report describes a laboratory-confirmed index case of LF in Kwara state, Nigeria. The case of LF in Kwara state was a 30-year-old woman who presented with a history of fever, headache, and abdominal pain and had been treated for malaria. On 13th February 2020, the Kwara State Ministry of Health was notified of a suspected case of LF. The case visited health facilities in Kwara state, Nigeria, and the Republic of Benin during her illness. Blood samples were obtained from her, and she was confirmed a positive LF case in the Republic of Benin. Although LF diagnosis is challenging, multisectoral collaboration and effective community engagement within the framework of the International Health Regulations is required to control the LF outbreak promptly.

This study aimed to determine community-initiated Lassa fever prevention and control strategies in Africa.

Literature search was performed on four databases, including PubMed, Google Scholar, African Journal OnLine (AJOL), and BioMed Central, using different combinations of the following search terms. A three-stage methodology was employed to conduct the study. At first, related articles were identified using pre-defined key terms, such as Lassa fever, Lassa fever control, Lassa fever prevention, community engagement and Lassa fever, and community participation and Lassa fever. Thereafter, articles were screened to remove duplicates and articles not relevant to the study objectives.

Community mobilization and sensitization and risk communication were some of the community-directed activities towards Lassa fever prevention and control. Also, stakeholders’ advocacy and engagement, rodent control practices, environmental sanitation, and proper food processing and preservation were practiced to prevent Lassa fever. In addition, a referral mechanism from the community to the health facility was constituted through the engagement of community health workers.

Health program managers should strive to provoke coordinated and sustainable community-initiated efforts to improve rodent preventive and control measures. Strategies should be developed and implemented to promote environmental sanitation and restrict cultural practices facilitating contact with rodents or infected persons.

Lassa fever is a severe, often-fatal and one of the most virulent disease in primates. However, the mechanism of escape of virus from the T-cell mediated immune response of the host cell is not explained in any studies yet. In our studies we had aimed to predict B- and T- cell epitope of Lassa virus protein, for impaling the futuristic approach of developing preventive measures against this disease, further we can also study its presumed viral- host mechanism.

Peptide based subunit vaccine was developed from all four protein against Lassa virus. We adopted sequence, 3D structure and fold level in silico analysis to predict B-cell and T-cell epitopes. The 3-D structure was determined for all protein by homology modeling and the modeled structure validated.

One T-cell epitope from Glycoprotein (WDCIMTSYQ) and one from Nucleoprotein (WPYIASRTS) binds to maximum no of MHC class I and MHC class II alleles. They also specially bind to HLA alleles namely, A*0201, A*2705, DRB*0101 and DRB*0401.

Taken together, the results indicate the Glycoprotein and nucleoprotein are most suitable vaccine candidates against Lassa virus.