جستجوی مقالات مرتبط با کلیدواژه "lavender oil" در نشریات گروه "پزشکی"

This study aimed to investigate the potential effects of different doses of Lavender angustifolia essential oil (Lavender EO) administered by inhalation on sleep latency and neuromodulators regulating the sleep/wake cycle in rats with total sleep deprivation (TSD).

Forty-eight male Sprague-Dawley rats were divided into five groups: Control, Alprazolam (ALP, 0.25 mg/kg given intraperitoneally), L1 (Lavender EO, 0.3 ml given by inhalation), L2 (Lavender EO, 0.5 ml given by inhalation), and L3 (Lavender EO, 1 ml given by inhalation); TSD was applied to all groups. Rats in SD groups were kept on a platform surrounded by water for 18 hr for 20 days, and for the remaining time, the animals were exposed to Lavender EO for 1 hr (11:00–12:00) and then were kept in their home cage for 5 hr (12:00-17:00). Their brain and brainstem were removed for histopathological and immunohistochemical analyses (c-Fos, ChAT, GAD, and ADRB2 expression) in the locus coeruleus (LC), basal forebrain (BF), and preoptic area (PO).

The groups ranked by the severity of edema, hyperemia, and neurodegeneration in LC, BF, and PO areas were control, L3, L1, L2, and ALP. c-Fos expression significantly decreased in all brain regions in all groups except the L1 group. ChAT and GAD expressions increased dramatically in all brain regions. ADRB2 significantly increased in LC in ALP and L2 groups; in the PO area in ALP, L1, and L2 groups; and in BF in all groups. 

Lavender EO treatment ameliorated c-Fos, ChAT, GAD, and ADRB2 expression, similar to the effect of ALP.

 The postpartum period is often accompanied by significant pain which affects maternal well-being and care of newborns. With an increasing interest in natural and safe alternatives to conventional pain management strategies, this study was performed with the aim to evaluate the efficacy of ginger extract and lavender oil capsules in managing postpartum pain.

 This single-blind, randomized clinical trial study was conducted at Baghdad Teaching Hospital, Iraq in 2023-2024. Ninety postpartum women were allocated to receive either ginger extract (250 mg per capsule) or lavender oil (100 μL per capsule) capsules orally (n=45 in each group). Pain was assessed using the Visual Analog Scale (VAS) at baseline and one-hour post-intervention, with follow-up over the first 24 hours post-delivery. The changes in pain scores, maternal satisfaction, and the incidence of side effects were compared between the two groups.

 Both ginger extract and lavender oil capsules significantly reduced postpartum pain scores compared to baseline (P<0.001), with the lavender oil group experiencing a marginally greater reduction (from 6.1 ± 1.2 to 2.8 ± 1.0) compared to the ginger extract group (from 6.2 ± 1.3 to 3.4 ± 1.1) (P=0.035). Side effects were minimal and not significantly different between the two groups (P=0.29). Maternal satisfaction was significantly higher in the lavender oil group (91%) compared to the ginger extract group (82%) (P=0.044).

 Orally administered ginger extract and lavender oil capsules are effective in reducing postpartum pain, with lavender oil showing marginally higher efficacy and greater maternal satisfaction. These findings support the integration of these natural remedies into postpartum care, offering safe and effective alternatives for pain management.

Pain experienced during the insertion of a catheter into the arteriovenous fistula (AVF) and restless legs syndrome (RLS) are prevalent issues amongHemodialysis (HD) patients. The primary objective of this systematic review and meta-analysis was to consolidate the findings from randomized clinical trial (RCT) studies examining the impact of aromatherapy with lavender on the pain associated with AVF catheter insertion and RLS in HD patients.

A systematic search was conducted on PubMed,Web of Science, Scopus, Cochrane, Embase, ClinicalTrials.gov, andGoogle Scholar search engine from inception to August 1, 2022, using keywords extracted fromMedical Subject Headings, such as “Aromatherapy”, “Lavender”, “Arteriovenous fistula”, “Pain”, “Restless legs syndrome”, and “Hemodialysis”.

Finally, eleven articleswere included in this systematic review and meta-analysis. The results showed that aromatherapy reduced the average pain of catheter insertion in AVF compared to the control group (StandardMean Difference: -1.60, 95% Confidence Interval: -2.32 to -0.87, Z=4.32, I2:90.3%, P<0.001). Also, aromatherapy massage reduced the average severity of RLS compared to the control group, which was statistically significant (Weighted Mean Difference: -13.21, 95% Confidence Interval: -17.50 to -8.91, Z=6.03, I2:93.0%, P<0.001). Also, the subgroup analysis showed that lavender in the intervention group significantly decreased the pain intensity compared to the "no intervention" group (P<0.001), yet it was not significant compared to the placebo group (P=0.12).

In summary, the findings indicate a notable reduction in catheter insertion pain in AVF and relief from RLS among HD patients through the use of lavender essential oil. As a result, future research is encouraged to include a comparison of lavender’s effects with those of a placebo group.

Too much crying is a self‑limiting problem and disappears within a few weeks. However, it can lead to maternal depression and parental stress. This study aimed to evaluate the effect of lavender oil inhalation on the duration of night crying within a week of intervention among infants with infantile colic.

In this double‑blind randomized clinical trial, the inclusion criteria for infants were being healthy, not taking any medications for colic, having an episode of crying two hours a day, and having a healthy mother. The intervention group received lavender oil inhalation and the control group received sweet almond oil inhalation for seven days. The data pertaining to the duration of crying were collected four times a day (morning, afternoon, evening, and night) via telephone contact. Mothers’ mood scores were also assessed at the beginning of the study and on the seventh day of the intervention.

At first, the two groups were not different in terms of the duration of crying. After the intervention, however, a significant difference was observed in this regard on all seven days of the study (P < 0.001). Based on the results of the repeated measures analysis, the difference between the two groups was statistically significant (P < 0.001).

The results showed that inhalation of lavender oil at low concentrations could reduce colic symptoms and improve maternal mood.

This study was conducted to examine the therapeutic effects of lavender oil (LO) against oxygen-glucose deprivation (OGD)-induced injury in vitro model.

In this study, the OGD model was induced in the H9C2 cell line, and then the cells were treated with LO (10, 100, 1000, and 10000 μg/ml). The anti-inflammatory activity of LO (Jak2/Stat3) was evaluated by immunocytochemical assay. Likewise, the p-ERK/ERK level was measured by western blotting.

Compared with only the OGD-induced injury model, cell survival increased after treatment with LO. Our results showed that 100 μg/ml of LO significantly decreased the expression of Jak2/Stat3 and the apoptotic activity 72 hr after reperfusion compared with the control group. Likewise, significant increases were observed in p-ERK/ERK in LO-treated groups. 

Collectively, these findings confirm that LO can be a good candidate to reduce OGD-induced injury in the H9C2 cell line through targeting Jak2/Stat3 and ERK pathways.

The pure essence of plants (essential oils) provides both psychological and physiological benefits when used accurately and safely. Conventionally, Lavender oil is known for relaxing, carminative, and sedative effects. Hence, an attempt was made to know the effect of Lavender essential oil on dental patient anxiety.

The present study included two comparison groups (Lavender and control group), each comprising five dental clinics. In Lavender group, the ambient odor of Lavender essential oil was maintained with the help of a candle warmer in the reception area and in the control group, candle warmer with normal water was used. A total of 597 patients, aged above 18 years were included. A questionnaire comprising demographic information, and a modified dental anxiety scale was given to the patients in waiting room, and data regarding anxiety levels was recorded.

Student’s t‑test (unpaired) showed a significant reduction in anxiety scores of Lavender group compared with the control group. Analysis of variances test showed reduction in anxiety scores as age increased in Lavender group.

Fragrance of Lavender oil at reception area may effectively reduce the patient’s state or current anxiety. This practice on routine usage can improve the quality of dental treatments.

Poor quality of sleep is one of the most common problems among the older adults. Non-pharmacological interventions are considered as a better option for the treatment of sleep problems in the older adults. The aim of present study was to examine the effects of aromatherapy with lavender essential oil on sleep quality in the older adults. This single -blind randomized controlled clinical trial was conducted on 100 retired older adults. Participants were selected through non-probability-convenient sampling method and they were divided into two groups using simple random sampling. The intervention group received 2 drops of lavender essential oil and the control group received 2 drops of placebo in a glass of water, during bed time, for 7 nights. All participants filled out the Pittsburgh Sleep Quality Index before and after the intervention. There was no statistically significant difference between groups in terms of socio-demographic characteristics sleep quality score before intervention (p > 0.05). A significant difference in sleep quality was observed in the group receiving lavender  essential oil compared with the control group at 7 night  after intervention (p<0.001). lavender essential oil has a positive effect in improving older adults’ sleep quality. However, further studies are needed on a more general population in order to decide on its use as an appropriate non-pharmacological intervention to use in sleep problems.