جستجوی مقالات مرتبط با کلیدواژه "lee index" در نشریات گروه "پزشکی"

High-fat diet (HFD) leads to adverse changes in skeletal muscles. Regular exercise reduces skeletal muscle disorders by maintaining physical function. This study aimed to assess the effect of high-intensity interval training (HIIT) on muscle strength, endurance capacity, food consumed, energy intake, and Lee index in male rats consuming a HFD and normal diet (ND). 44 rats were divided into four equal groups, including ND control, HFD control, HIIT+ ND, and HIIT+ HFD. The HIIT was performed for 12 weeks at 85-90% of the maximum speed. Data were analyzed by repeated measures analysis of variance and one-way analysis of variance at a significance level of P<0.05. Food consumed and energy intake were lower and higher, respectively in the HFD control group compared with the ND control. Also, the body weight, Lee index, food consumed, and energy intake in the HIIT+HFD group were significantly lower than in the HFD control group and Lee index and food consumed in the HIIT+HFD group were significantly lower than in the HIIT+ND group. Furthermore, the endurance capacity in the HIIT+HFD group was significantly higher than in the HFD control group and in the HIIT+ND group was significantly higher than the ND and HFD controls. Absolute and relative muscle strength also increased and decreased in all groups, respectively. It seems that performing HIIT despite consuming a HFD leads to improved physical function and reduced body weight gain.

Semaphorin 3C (Sema3C) is a relatively new and lesser-known adipokine. Recent studies have demonstrated that the class 3 semaphorin subfamilies have the most significant role in metabolic disorders. Therefore, the present study aimed to investigate the effect of obesity on skeletal muscle Sema3C levels in male and female Wistar rats.

In this experimental study, 12 male and female 8-week-old Wistar rats with a mean weight of 138 ± 13.60 gr were randomly assigned to two groups of six: non-obese (three males and three females) and Obese (three males and three females). The rats were dissected after eight weeks of induction of obesity and 18-20 hours of fasting, and their skeletal muscle tissue was rapidly removed and frozen. The sema3C level of skeletal muscle was measured by ELISA. Data were analyzed in SPSS software (version 21) using a two-way ANOVA test at a significance level of P≤0.0. In addition, the effect of obesity intervention was investigated in male and female rats separately.

Based on the results of the present study, the level of Sema3C in male and female rats in the obese group increased; nonetheless, it was not significant (P≥0.05). Moreover, Lee's index did not change significantly in male and female rats in the obese group (P≥0.05).

It seems that a high-fat diet increases the level of Sema3C in skeletal muscle which can have negative effects on the whole body system considering the role of this adipokine in the spread of metabolic diseases