جستجوی مقالات مرتبط با کلیدواژه "lepidium sativum" در نشریات گروه "پزشکی"

Diabetes can adversely affect spermatogenesis. Garden cress plant, known as Lepidium sativum, contains antioxidants. This study aimed to evaluate and compare in vivo antidiabetic activities of hydroalcoholic garden cress seed extract and insulin on diabetic rats.

In this experimental study, diabetes was induced in the animals using streptozotocin (STZ; 60 mg/kg). Fifty rats were divided into five equal groups as follows: Groups 1, nondiabetic rats; group 2, diabetic rats induced by streptozotocin; Group 3, diabetic animals that received streptozotocin plus insulin; and groups 4 and 5 were diabetic rats that received 200 and 400 mg/kg garden cress seed extract respectively by gavage for 4 weeks. At the end of the study, the sperm parameters obtained from the tail of the left epididymis and biochemical parameters were analyzed and compared among the groups. Data were analyzed by one-way ANOVA.

The sperm parameters of the diabetic groups receiving 200 and 400 mg/kg of garden cress extract demonstrated a significant increase in all parameters compared to those of the diabetic control group. Administration of garden cress extract as a powerful antioxidant led to compensation for the streptozotocin toxicity and improved sperm quality.

Administration of the Lepidium sativum seed extract compensated for the Streptozotocin-induced harmful effects. Our findings suggested that use of the garden cress seed extract and insulin therapy may have a potential protective effect on diabetes mellitus.

Long-term used of sewage sludge and fertilizer causes accumulation of heavy metals in the soil, which may lead to excessive absorption of these elements by plants and consequently entering these toxic metals into the human and animal food chain. Therefore, this study was conducted to investigate the effects of bio-organic and chemical fertilizers application on the absorption of macronutrients and heavy metals in Lepidium sativum.

In this descriptive study, the experiment was carried out in a completely randomized design with three replications in the environment and greenhouse conditions. Fertilizer treatments included chemical fertilizer treatment (diammonium phosphate), anaerobically digested sludge compost, sludge compost without digestion and raw sludge at the weight of 28, 57 and 115 g and control treatment. Finally, the concentrations of heavy metals Pb, Cd, Hg and As and macronutrients including phosphorus, nitrogen and carbon in the leaf of L. sativum were measured using ICP-OES. All statistical analysis was performed using SPSS version 21.

The results showed that the maximum mean concentrations of As and nitrogen in L. sativum vegetables were 0.592 and 10.2 mg/kg in 115 g raw sludge treatment, the maximum mean concentration of Cd, Hg, Pb, carbon and phosphorus elements in L. sativum were 0.956, 0.701, 1.25, 98.5 and 10.3 mg/kg, respectively in 115 g treatment raw diammonium phosphate fertilizer. The results of variance analysis showed that there was a significant difference between fertilizer, sludge and control treatment and there was a significant difference between amounts 28, 57 and 115 g from fertilizer treatment in L. sativum in terms of concentration of heavy metals and macronutrients (p < 0.050).

In conclusion, it was concluded that increasing the amount of fertilizer and sludge in the soil leads to an increase in the concentration of heavy metals and macro nutrients in L. sativum. Therefore, in the use of fertilizers and sludge for agricultural lands, it is necessary to pay attention to this issue. It was also found that the highest uptake of heavy metals and macronutrients in L. sativum was related to raw sludge treatment and diammonium phosphate fertilizer, which is indicating better quality of compost with respect to chemical fertilizer and raw sludge.