جستجوی مقالات مرتبط با کلیدواژه « male sex » در نشریات گروه « پزشکی »

Novel coronavirus disease 19 (COVID-19), was reported by the WHO as a pandemic in March 2020. It was associated with liver injury in up to 50% of patients. retrospective cohort study to investigate the prevalence and associated factors of liver injury among patients with COVID-19. We include 2319 consecutive COVID-19 patients from April 2020 to November 2020. Liver function tests were performed at baseline, 24–48 h after admission, and before mortality/discharge. We compared Saudis and non-Saudis, in the admission rate, serum ALT level, morbidity, and mortality. Serum ALT was compared between, sexes, between admitted and non-admitted patients, and between deceased and survivors. Men were predominant (1356 [58.5%]) and non-Saudis (1328 [57.3%]). The mean (SD) age was 41.67 18.3 years (18-100). One-third of the patients had comorbidities, and 1022 (44.1%) required hospital admission. Intensive care unit (ICU) transfer was required in 185/1022 (18%) . Male and non-Saudi were most likely to be transferred to the ICU (P<0.001). Hepatocellular liver injury was found in 797 (34.4%) patients. Male and admitted patients were more likely to have hepatic injury (P=0.001). The mortality rate among admitted patients was 17.8% (182/1022). Mortality was associated with older age and hepatic injury (P<0.001 and P=0.004, respectively).

Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebral ischemia remains unclear. Here we reviewed current understanding of testosterone (TES) neuroprotective activity against ischemic stroke and mechanisms underlying these effects in aging. TES may exert a neuroprotective effect in aging through pathways including inhibition of oxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain and modulation of apoptotic cell death. Given this, a better understanding of the neuroprotective roles of TES may propose an effective therapeutic strategy to improve the quality of life and decrease androgen-related cerebrovascular problems in the aging men.