جستجوی مقالات مرتبط با کلیدواژه « male wistar rats » در نشریات گروه « پزشکی »

Silymarin is utilized in the treatment of liver conditions primarily because of its antioxidant properties and its ability to lower blood lipid levels. Propofol, an anesthetic and antioxidant, is harmful to patients with hyperlipidemia. The aim of this study was to investigate the beneficial effects of silymarin and propofol on liver enzymes and blood indices. We also studied the impacts of propofol and silymarin on propofol-induced hyperlipidemia in male Wistar rats.

The rats were divided into four groups: 1) controls; 2) silymarin; 3) propofol; and, 4) combined propofol and silymarin. On the 22nd day after the treatments, all rats were anesthetized, and their blood samples were collected to estimate the levels of AST, ALT, ALP, LDH, TG, TC, LDL-C, and HDL-C. After being sacrificed, the liver was removed from each rat to determine the levels of MDA, GPx, GSH, and CAT. Moreover, histopathological examinations were performed on all liver samples.

Silymarin and propofol, used either separately or in combination, had a favorable effect on the indicators of oxidative stress and the liver’s antioxidant markers. The propofol treatment alone significantly increased the blood lipid parameters. The administration of Silymarin had a modulating effect on propofol-induced hyperlipidemia in rats.

Propofol and silymarin had favorable effects on the liver; however, propofol increased the blood lipids due to its lipid structure, which is a warning for patients with hyperlipidemia. In this regard, silymarin may be considered a protective option, making it a potential treatment for patients experiencing hyperlipidemia induced by propofol.

The aim of the study was to compare the effect of 6-week interval and Continuous training with Zizphus Vulgaris Extract supplementation on the hippocampus’s BDNF male Wistar rats.

Among 36 male rats (250-350 gr), randomly after adjusting the body weight, 6 rats were separated as the control group. 30 rats were divided into 5 groups: Continuous group (n=6), Interval group (n=6), Continuous with Zizphus Vulgaris Extract group (n=6), Interval with Zizphus Vulgaris Extract group (n=6) and Zizphus Vulgaris Extract group (n=6). The training groups completed 8 weeks of the training program, 5 days/week according to protocol. The Endurance Continuous protocol includes running exercise on a treadmill for, 10 m/min, 10 min/day to up 16 m/min, 40 min/ day. Endurance Interval protocol includes running exercise on a treadmill for, 5*4 min, with intensity 10 m/min to up 23 m/min, 52 min/ day. The Zizphus Vulgaris Extract group, every 6 weeks, each rat consumed 400 mg/kg.day and 1.5 mL. At the end of the intervention, the animals were euthanized and the hippocampus’s BDNF was measured. Data were analyzed using one way ANOVA tests (Pvalue<0.05).

Interval with the Zizphus Vulgaris Extract group had significantly increased hippocampus’s BDNF compared to control and Zizphus Vulgaris Extract groups ( respectively p= 0.01, p= 0.02). Other comparisons were not significant.

Interval with Zizphus Vulgaris Extract induce more effective favorable changes in the hippocampus’s BDNF in male rats. Likely, that be the best Strategy to prevent negative effects on the hippocampus’s BDNF decrease.

Bisphenol A is a xenoestrogen, synthesized in large quantities for the production of polymers (polycarbonates, epoxy resins) and thermal paper, and is widely used in products of everyday use (packaging, containers and bottles). Data concerning the occurrence of BPA in food, water and indoor environments as well as its appearance in tissues and body fluids of the human body are available in the literature. Male accessory sex glands are also vulnerable to environmental endocrine disruptors with adverse effects in adulthood. The developing prostate gland is particularly sensitive to estrogens and high-dose exposures during a critical developmental window results in intraepithelial prostatic neoplasia (PIN) in adult rodent models. Bisphenol A is also an endocrine disruptor. High levels of BPA exposure correlate with increased risk of mammary gland, brain and prostate cancers and have adverse effects on the tissues of the prostate and seminal vesicles.
The aim of this study was to investigate the effects of BPA doses on the histological structure and ultrastructure of prostate and seminal vesicle glands.
Forty male Wistar rats were randomly divided into four groups (n = 10): A control group and three treatment groups, receiving BPA at doses of 10, 50 and 100 µg/kg. Bisphenol A was administrated intraperitoneally for 15 days. As the prostate and seminal vesicle glands were dissected on the day 16, the structure and ultrastructure histological parameters were analyzed, using light and electron microscopes.
The main pathological finding observed in the prostrate and seminal vesicle glands, using light microscope, revealed congestion in the connective tissue and vacuolization in the secretory units of epithelial cells and epithelium rupture at 50 and 100 µg/kg doses of BPA. Ultrastructure study showed vacuolization of mitochondria, condensation of nuclei and disappearance of nucleus in the prostate tissue. Pathological changes showed the vacuolization and dilation of endoplamic reticulum (ER) and secretory glands and disappearance of microvilli. They also showed an increase in collagen fibers around the cells in the seminal vesicle tissue in the treatment group that received 100 µg/kg BW BPA.
This study revealed that BPA has adverse effects on the reproductive system in male rats. The results also revealed that BPA has destructive effects on the prostate and seminal vesicle glands.