جستجوی مقالات مرتبط با کلیدواژه "moderate exercise" در نشریات گروه "پزشکی"

Post-traumatic stress disorder (PTSD (is a psychotic illness caused by different types of stressors and is associated with high economic and psychological burdens on health systems. Physiological studies of the brain have shown that serum corticosterone and insulin-like growth factor 1 (IGF-1) levels have important roles during brain damage and trauma to the nervous system. In this project, we studied the effect of exercise as an effective factor on improving anxiety and serum levels of corticosterone and IGF-1in male PTSD rats.

In this experimental study, single prolonged stress (SPS) was used to induce PTSD in male Wistar rats. The animals were divided into two groups: Sham (Non-SPS [NSPS]) and SPS. The two groups were then divided into two subgroups and one of the subgroups in each group did the exercise after two weeks which continued for four weeks according to the following program: moderate treadmill exercise, 5 days a week; the first two weeks 10m/min and the second two weeks 15m/min). Then, anxiety test was performed by open field test and serum levels of IGF-1 and corticosterone were measured using Eliza.

The rats in SPS group exhibited increased anxiety levels in open field test, decreased serum IGF-1 levels, and increased serum corticosterone levels compared with the controls. Moderate treadmill exercise alleviated SPS-induced alterations, anxiety, and IGF-1 and corticosterone levels.

Moderate exercise could be used as a useful complementary treatment in behavioral and molecular injuries in PTSD patients.

Post-traumatic stress disorder (PTSD) is a condition that develops after experiencing major trauma. Selective serotonin reuptake inhibitors (SSRIs) are first-line treatment for PTSD. This study aimed at investigating the effects of moderate treadmill exercise and fluoxetine on anxiety, spatial memory, and positive tunnel cells in the hippocampus in a rat model of PTSD.

We used single prolonged stress (SPS) model as an animal model for PTSD. Male and female rats were divided into two groups: Sham and SPS. After Two weeks, interventions, including treadmill exercise (4 weeks, 5 days per week), fluoxetine (10 mg/kg/day), and combined treatment were performed. Then, anxiety and memory test and tunnel assessments were done.

SPS rats exhibited increased anxiety levels in light/dark box and enhanced hippocampal apoptotic cells. Male SPS rats showed impaired spatial memory in object-location memory task. Treadmill exercise, fluoxetine, and combined treatment reduced anxiety levels, improved spatial memory, and decreased positive tunnel cells in the hippocampus. Furthermore, combined treatment with fluoxetine and treadmill exercise was found to be more effective than fluoxetine alone. Female rats had more resilience than male rats.

Combined intervention with moderate exercise and fluoxetine is more useful in treatment of behavioral and cellular injuries in PTSD patients.

Post-traumatic stress disorder (PTSD) develops after major trauma that is accompanied by certain signs, including pervasive fear memories, anxiety, abnormality in spatial and cognition memory, and decrease in hippocampal brain-derived neurotrophic factor (BDNF). Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PTSD. This study aimed at investigating the effects of moderate treadmill exercise and fluoxetine on spatial memory and serum BDNF levels in rat model of PTSD.

In this experimental study, single prolonged stress (SPS) animal model of PTSD was used. Male and female rats were divided into SPS and control groups (n=10 per group). After that, they were subjected to moderate treadmill running (5 days per week/four weeks) and fluoxetine (10 mg/kg/day). Then, behavioral assessment and BDNF measurement were done.

SPS male rats showed reduced spatial memory and hippocampal BDNF. Female rats showed more resistance to SPS than male rats. This may be due to the effects of gonadal hormones. The intervention alleviated the SPS-induced alterations in hippocampal-dependent spatial memory and BDNF serum levels in both male and female rats (P<0.05).

Combined exercise and fluoxetine administration are more effective in alleviating behavioral and molecular deficits in PTSD patients.