جستجوی مقالات مرتبط با کلیدواژه « motor balance » در نشریات گروه « پزشکی »

Multiple sclerosis (MS) is a chronic inflammatory demyelinating factor of the central nervous system that leads to decreased balance and increased risk of falls. The aim of this study was to investigate the interactive effects of endurance training (T) with royal jelly (RJ) consumption on the motor balance of rats with MS. 

In this experimental study, 56 rats with MS (using complete Freund’s adjuvant) were divided in 7 groups of eight animals, including: 1) control (MS), 2) Sham (royal jelly solvent), 3) 50 mg/kg RJ, 4) 100 mg/kg RJ, 5) T, 6) T+RJ50, 7) T+RJ100. Rats in the royal jelly consumption groups received the prescribed doses of royal jelly peritoneally each day for 5 weeks. Also, rats in the endurance training groups performed endurance training on a rat treadmill for five weeks, five sessions per week, each session 30 minutes at a speed of 11 m/min. At the end of 48 hours after the last training session and royal jelly consumption, the motor balance of rats was measured using a rotarod device. Also, the weight of brain cerebellum tissue was measured by a digital scale. The one-way analysis of variance with Tukey’s post hoc test were used to analyze the findings (P≥0.05). 

The duration of motor balance in the T, T + RJ50 and T + RJ100 groups was significantly higher than the MS group (P = 0.001); also, in the T + RJ50 and T + RJ100 groups, it was significantly higher than the RJ50 and RJ100 groups (P = 0.001). 

It appears that training and royal jelly consumption have an interactive effect on improving motor balance, and improving motor balance is training-dependent. Given the existence of effective physiological mechanisms, it seems necessary to conduct further studies by examining the pathological and physiological aspects.

The Alzheimer disease (AD) induces the central and peripheral nervous system disruption by increasing oxidative stress; therefore, it induces disruption of the physical condition as well as occurrence of chronic pain.

The present study aimed at investigating the interactive effects of endurance training (ET) on positive and negative slope and royal jelly (RJ) consumption on motor balance and pain threshold in animal model of AD.

The current experimental study was conducted on 49 male Wister rats with AD divided equally into seven groups including AD control (ADC), ET on positive slope (ETPS), ET on negative slope (ETNS), sham (RJ solvent) (SH), ETPS + RJ, ETNS + RJ, and RJ. In order to investigate the effect of AD induction on motor balance and pain threshold, seven rats were assigned into the healthy control (HC) group. The rats in the ET groups performed ET for four weeks and five 60-minute sessions weekly, and the RJ groups received 100 mg/kg RJ daily for four weeks. One-way ANOVA and two-way ANOVA with Bonferroni post-hoc tests were employed to analyze the data (P ≤ 0.05).

ETPS, ETNS, and RJ consumption significantly increased motor balance in rats with AD (P ≤ 0.05). Also, ET and RJ consumption had interactive effects on increasing the motor balance in rats with AD (P ≤ 0.05). ETPS significantly reduced pain threshold in rats with AD (P ≤ 0.05); nevertheless, ET and RJ consumption had no interactive effects on reduction of the pain threshold in rats with AD (P ≥ 0.05).

It seems that to improve the motor balance in AD, ETPS and ETNS can be employed with RJ consumption.