جستجوی مقالات مرتبط با کلیدواژه « ms disease » در نشریات گروه « پزشکی »

Cytokines play an important role in my disease and are considered an important target for therapeutic interventions. the purpose of this research is to investigate the effect of a period of resistance training on the serum level of 17 and interferon beta in young women with MS. Was.

The present study was conducted in a semi-experimental way with a pre-test and post-test design. 30 women with MS with age range of 30-35 years were randomly selected in two exercise and control groups. Resistance exercises were performed for 8 weeks and three sessions a week, each session lasting 60 minutes with an intensity of 60-70% of the maximum heart rate. Blood samples were taken before and after the training protocol with 12 hours of fasting and the levels of interleukin 17 and beta interferon were measured by ELISA method. Data were analyzed using SPSS version 22 software and covariance test.

The results showed that after 8 hours of resistance training intervention, the amount of interleukin 17 in the training group decreased significantly and the amount of beta interferon showed a significant increase compared to the control group

Since moderate intensity resistance training decreased interleukin 17 and increased beta interferon in patients with MS, it seems that exercise intervention can be used to treat and prevent the progression of MS along with used drug treatments.

MS is a disease of the central nervous system in which the body makes a defensive attack on its tissues. The disease can affect the brain and spinal cord and cause a wide range of potential symptoms, including balance, motor and vision problems. MRI and FMRI images are a very important tool in the diagnosis and treatment of MS. The aim of the present study was to determine and diagnose early diagnosis of MS in MRI images of the brain using deep learning techniques.

The present experimental study was conducted at Kazerun Azad University in 2020. 1000 images were from BRATS data sets and in the two groups of learning and testing, 70 to 30% were included in the study and a deep four-layer deep learning network based on the network. Convulsive neuralgia is simulated in MATLAB environment. In the deep learning structure, which itself had the ability to extract features, we used another method to do so. For the reason that deep learning, although capable of extracting features was also conducted by chance. In order for the previous steps to be definite, the researchers used another algorithm inside the iteration loops and inside the torsion layer to reduce the dimensions of the feature during the training, secondly to select the best features and thirdly to extract the features definitively.1000 MRI images of BRATS data set in the two groups of learning and testing in the ratio of 70 to 30% were included in the study. A four-layer deep learning network based on convolutional neural network is simulated in MATLAB environment. In the deep learning structure, which had ability itself to extract features, another method was used to do this. For the reason that deep learning has the ability to extract features, but did so randomly. In order for the previous steps to be definitive, another algorithm was used inside the iterative loops and inside the torsion layer to reduce the dimensions of the feature during the training, secondly to select the best features and thirdly to extract the features definitively.

The graphical representation of the ROC curve indicated that the degree of sensitivity or correct prediction against incorrect prediction in this binary classification system in which the separation threshold varies was significant. The area below this curve was 0.8592 and the accuracy of the proposed method was 98.6891 and the sensitivity was 94.8766.

Due to the prevalence of MS disease, early diagnosis and presentation of an intelligent method based on fMRI imaging is essential for treatment. This intelligent method tries to be able to help diagnose and treat more accurately, better identify the features and patterns affecting the disease than previous methods as a physician assistant. Finally, the results obtained from the present study revealed that the efficiency of the proposed method was evaluated at an excellent level and showed its optimality as much as possible. In addition, the obtained results indicated the speed of training and testing of data in high volume and fast convergence of the algorithm. It is correspondingly easier to expand and generalize.

Physical activity is one of the several factors which stimulate the secretion of growth and nerve growth factors in patients with Multiple Sclerosis (MS). Therefore, the aim of this study was to evaluate the effect of 12 weeks of Pilates training and ginger consumption on serum level of BDNF and TNF-α in women with MS.

Forty women with MS were randomly selected from 85 women referred to the Welfare Office of Urmia city, in Iran, with the age range of 30-35 in the form of a pre-test and post-test quasi-experimental study design. Participants were divided into four groups including: exercise+ supplement, exercise+ placebo, ginger supplement and control group with 10 individuals in each group. The intervention groups performed Pilates exercises for 12 weeks, 3 sessions of 60 minutes every week, and the supplement groups took three ginger capsules of one gram daily. In order to analyze the data, analysis of covariance was done using SPSS-22 software.

The results showed that ginger consumption combined with physical exercises increases BDNF in the intervention groups compared to the control groups, but this increase is more significant in the exercise+supplement group (p<0.05) than other groups. Also, the results showed that TNF-α level has a significant decrease in the intervention group compared to the control group (p<0.05).

The results showed that ginger consumption as a non-invasive method can have a positive effect on increasing BDNF level and decreasing TNF-α level in women with MS.

Multiple Sclerosis (MS) is a part of a group of diseases of the nervous system that is associated with the destruction of the myelin sheath of the nervous system. Due to its disabling nature, the complications of this disease cover all aspects of the person's life and thus reduce the patient's life expectancy. The reduction of life expectancy also contributes to marital conflicts in the lives of these patients. In this regard, the present study was conducted to determine the effectiveness of real-therapies on reducing marital conflicts and hopelessness in women with MS. The research method was a quasi-experimental design with pre-test post-test design with control group. The statistical population of this study included all women with MS who referred to the MS Society and Sine Hospital in Tehran in 2015. Using a suitable sampling method, 31 MS patients with marital conflicts and hopelessness were selected and randomly assigned to two experimental groups and evidence have been replaced. Before the intervention program, the two groups were tested by sickness and hopelessness conflict questionnaires, then the experimental group received real-therapeutic training for 10 sessions of 2 hours and the control group received no intervention. After intervention, both groups were tested by questionnaires. To analyze the data, multivariate analysis of covariance was used. The results of covariance analysis showed that group reality therapy caused a significant difference (p<0.001) between pretest (M=112.90) and post test (M=90/06) in total score Marital conflicts as well as pretest (M=17.01) and post-test (M=13.70) were in the experimental group. In the post-test, after the control of the pre-test scores, the experimental group reported fewer marital conflicts and disappointment than the control group. Group reality therapy in MS patients makes it possible to know their needs and talk about their spouses, thus it can play an important role in improving marital conflicts and reducing their hopelessness.

Multiple sclerosis is an autoimmune disease causing disability in . The environmental factors play an important role in disease spread and since youths are affected more, this disease is of a great importance. As the incidence of this disease is not the same around the world, through using geographic information system, the spatial and descriptive data can be used to create maps, tables, and charts for data analysis and preventing the progression of the disease.
In this descriptive study, 1200 Multiple sclerosis patients in Kerman province between 1987 and 2015 were surveyed. After collecting data and spatial data, the geographical distribution map of the disease was prepared. In this base, first, the points were inserted in the Google Earth and then, the locations of patient's accumulation were found by analyzing the hot spots.
According to the results, the majority of patients were habitants of the margin of Kerman and in the Salsabil area. The lowest numbers of patients were in Kuhbanan and Kahnouj. Women were affected 3.5 times more than men and the age group of 20 to 30 years old had the highest rate of this disease.
Improving urban infrastructures, reducing construction density, controlling traffic problems, and improving the quality of urban life can improve the health of patients.

Different factors are involved in the reduction of MS disease and can help the patient in the process of disease. Therefore, the present study aimed to predict the psychosocial adjustment in patients with MS based on the components of coping strategies and religious orientation.
Methods & Materials: The research method was descriptive and is one of the correlation studies. The statistical population is all of the patients with MS who referred to the associations in Tehran in the first quarter of 2016. A sample of 100 patients with MS (at least 19 years old and without psychiatric disorders) were selected through convenience sampling. Data were collected by Lazarus and Fulkman coping styles questionnaire, Dreguits psychological and social adjustment scale, and Allport religious orientation. To analyze the data, correlation coefficients and hierarchical multi-variable regression analysis were used.
The results showed that there was a positive and significant relationship between religious orientation and psychological compilation (p According to the results, it can be concluded that religious orientation and coping strategies are related to adaptation in patients with MS.

Multiple sclerosis is an inflammatory, chronic demyelinating disease of the central nervous system with unknown etiology. Due to the positive effects of exercise in patients with MS, we aimed to compare the effects of three combined exercise methods on serum levels of ghrelin, TNF-α and IL-10 in these patients. Forty- eight MS patients with EDSS 2 to 3 voluntarily participated in this study and were randomly divided into four groups; experimental-1 (one session of resistance training and three sessions of aerobic training per week), experimental-2 (two sessions of resistance training and two sessions of aerobic training per week), experimental-3 (three sessions of resistance training and one session of aerobic training per week) and a control group. The subjects performed four sessions of training protocol per week for eight weeks. Blood samples were collected 5 days before and 72 hours after the training program. The results of the data analysis using ANOVA and post hoc Scheffe test indicated that IL-10 levels significantly increased in the experimental group-3 than in groups one and two, but these changes were not statistically significant in the three experimental groups compared to the control group. The serum levels of TNF-α and Ghrelin were not significantly different among the groups. It seems that concurrent combined training with an emphasis on resistance training leads to increased levels of anti-inflammatory cytokines and reduces pro-inflammatory cytokines. However, decision on the best type of training programs in concurrent or combined training for MS patients calls for further research. As related to the improvement of serum Ghrelin levels in patients with MS, further studies with longer periods of exercises along with a proper diet is required.