جستجوی مقالات مرتبط با کلیدواژه « obesity surgery » در نشریات گروه « پزشکی »

Weight loss after Bariatric surgery is extremely variable and genetically influenced. Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNP) related to weight, body fat proportion and additionally feeding behaviors. Thus, the aim of this study was to research the effects of sequence variants and determined SNP on patient’s responses to bariatric surgery.

This review article summarizes studies that were investigating the influence of genetic polymorphisms in different effectiveness of bariatric surgery and weight loss pathways. Scopus and PubMed database were consistently searched up to January 2021.

The evidences from GWAS studies showed that many genes and SNPs affected the individual responses to bariatric surgery. the most of these SNPs is associated to genes that regulate the lipolysis/lipogenesis pathways, adipose cell metabolism, metabolic process chain, insulin resistance, insulin/glucagon metabolism, feeding behavior and appetite-sensing state. At this regard, rs16945088 SNP of FTO (fat mass and obesity-associated) sequence, MC4R (melanocortin 4 receptor), rs660339 (Ala55Val) SNP of uncoupling proteins 2 (UCP2), leptin receptor gene (Lys656Asn and Asn656Asn), gucagon-like peptide 1 receptor gene (rs6923761) and INSIG2 (insulin induced gene 2) are the most studied and affecting polymorphisms that have influence on bariatric surgery outcomes.

Genetic background encompasses a important impact on weight loss after bariatric surgery. within the future, genetic testing could probably be employed in the pre-surgical assessment of patients with severe obesity for selecting the best surgery procedure for patients, avoiding supernumerary adverse effects and prices

Obesity is considered as an independent risk factor for type 2 diabetes (T2D) and other metabolic diseases. Obesity accounts for about 55% of diabetes. This study aimed to investigate the therapeutic effects of obesity surgery on glucose, HbA1C, insulin and C-peptide serum levels in the patients with T2D.

Methods and materials: 

This prospective cohort study carried out on 25 patients aged between 18-70 years who had with T2D and body mass index above 40 kg /m2. Fasting blood sugar (FBS) level, HbA1C and Two-hour postprandial (2HPP), insulin level, and C-peptide were measured in all patients before surgery and the patients were fully evaluated for the presence of diabetes complications. The patients underwent Roux-en-Y Gastric Bypass (RYGB), mini-gastric bypass, and sleeve gastrectomy, and were re-evaluated 24 hours, one week, two month, and six months after surgery.

Twenty-five people underwent (sleeve gastrectomy for 12 cases, RYGB for 7 cases and mini-bypass surgery for 6 cases). Twenty cases (80.0%) were women and five cases (20.0%) were men. The mean age of the patients was 46.16 ± 10.97 years (25-67 years).The mean fasting blood sugar, 2HPP, HbA1C, insulin, and C-peptide in general and in all three groups showed a significant decrease.

The findings of the study showed that all three surgical procedures were effective in improving T2D by six months after surgery.

Obesity and obesity related comorbidities are increasing worldwide. Bariatric surgery plays a key role in treatment of morbid obesity and its related diseases. Bariatric procedures have been evolved in decades from initial procedures to modern and standard procedures. This evolution is continuing now to reach better and more persistent results with lower complications’ rates. In this manuscript we tell a brief history of this development.