جستجوی مقالات مرتبط با کلیدواژه "oleo-gum resin" در نشریات گروه "پزشکی"

Medicinal plants have effectively treated Alzheimer’s disease (AD). In this study, the oleo-gum-resin of Ferula persica known as sagapenum was selected to investigate its inhibitory activity toward enzymes involved in the creation and progression of AD. Also, the phytochemical analysis, which was not previously reported in the literature, was conducted. The in vitro inhibitory activity of dichloromethane, methanol, and aqueous extracts was investigated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) according to the modified Ellman’s method. Moreover, the phytochemical analysis of the most potent extract was conducted using different column chromatography techniques. The dichloromethane extract showed selective BuChE inhibitory activity (IC50 = 23.41 µg/mL), compared with donepezil as the reference drug (IC50 = 1.97 µg/mL). Phytochemical analysis of the related extract led to the isolation and identification of aurapten, farnesiferol A, umbelliprenin, farnesiferol C, farnesiferone A, karatavicinol, ferocaulidin, and ligupersin A, which were assayed toward cholinesterases (ChEs). Farnesiferol A was the most potent and selective inhibitor of BuChE (IC50 = 31.46 µg/mL). Moreover, it showed good β-secretase 1 (BACE1) inhibitory activity (IC50 = 5.14 µM), compared with the positive control, OM99-2 (IC50 = 0.014 µM) to be considered a multi-target directed ligand against AD. Selective anti-BuChE activity of the dichloromethane extract of sagapenum, as well as farnesiferol A and its good anti-BACE1 activity, may play a significant role in the development of anti-AD supplements.

The oleo-gum resin from Ferula gummosa</em> Bioss. is commercially important. Variability of geographic location has shown a deep effect on essential oil of different genus of plants. Thus, evaluation of oleo-gum resin of Ferula gummosa</em> from different locations is important for further studies. In the present study, phytochemicals profile of essential oil of oleo-gum resins from F. gummosa</em> in different geographic location and various bioclimates of Iran, were studied.

The oleo-gum resin of F. gummosa</em> was collected from different regions of Iran. The essential oils of the samples were extracted by Clevenger apparatus and were analyzed by GC-MS.

The highest amount of essential oil compared was observed in the samples from Damghan area (24.0%), Firuzkuh area (22%) and Kalat-e-Naderi area (22%). The variability in the oil composition of different samples exhibited a notable difference in monoterpenes content from 39.15 % to 87.48%. Based on GC-MS analysis, the major components were β</em>-pinene (5.11-63.80 %), sabinene (3.37-30.69%), α</em>-pinene (4.43-12.72%) and δ</em>-carene (2.38-10.23 %). The highest concentrations of β</em>-pinene (63.80%) and sabinene (30.69%) were observed in the Shiraz and Torbat-e-Jam essential oils, respectively.  The highest amounts of α</em>-pinene (12.72%) and δ-</em>carene (10.23%) were recorded in Firuzkuh and Shiraz areas, respectively.

Significant variation in the component of the essential oils from different oleo-gum resins can be used to improve the knowledge about the endemic medicinal plants.

In this experiment, the chemical composition of the essential oils obtained from Ferula assa-foetida oleo-gum resin collected from two different sites of Yazd province (Tabas and Yazd) in the center of Iran, were identified. The gas chromatography mass-spectroscopy (GC/MS) data showed that the qualitative composition of the components appeared to be constant in two different regions. Moreover, no remarkable variations were found in the amounts of the essential oil major constituents. A total thirty-nine components, comprising 91.52% and 95.61% of the total oil, were characterized in Tabas and Yazd samples, respectively. The hydrodistilled oils contained E-1-propenyl sec-butyl disulfide (40.15 and 44.36% in Tabas and Yazd samples, respectively), Z-1-propenyl sec-butyl disulfide (23.93 and 27.98%), Guaiol (5.50 and 3.14%) and Carotol (5.14 and 1.63%) as major constituents.