جستجوی مقالات مرتبط با کلیدواژه "oral neoplasms" در نشریات گروه "پزشکی"

Schwannomas are considered benign soft tissue tumors that originate from Schwann cells. Oral Schwannomas are rare and account for only 1% of all Schwannomas. Cellularschwannoma (CS) is a rare histological variant of schwannoma, characterized by high cellularity and cellular atypia. We present a case of localized growth of palatal mucosa that imitated the features of malignant peripheral nerve sheath tumor (MPNST) on histopathological examination; it was differentiated from MPNST by the correlation of clinical, histopathological, and immunohistochemical features.

Mesenchymal tissue origin is one of the most common lesion in oral cavity. Most of these lesions are exuberant response to local irritation produces a soft tissue enlargement which are similar to neoplastic pathologic processes. Due to this diagnostic challenge the present study was conducted for reviewing the prevalence of soft tissue lesions.

The English articles in scientific databases including Google Scholar, Sci- ence Direct, Medline, and PubMed, published between 2007 and 2019, were searched by using relevant keywords including oral soft tissue lesion, oral mucosal lesion, neoplastic soft tissue lesion, reactive lesion, hyperplastic lesion and non-neoplastic soft tissue lesion. Finally, forty-nine articles were reviewed in this study.

Findings showed that the most diagnosed lesions were benign in nature, and inflammatory in origin. Among this reactive/non-neoplastic lesions, fibrotic lesions, such as irritation fibroma or fibrous hyperplasia, were the most abundant lesions reported. There is a pronounced female predilection, and reactive lesions are most common in the fourth to sixth decades of life. Regarding the location of reactive lesions, the gingival mucosa was the most common site of involvement. Tumoral lesions with the origin of vascular, fibrotic and fat were the most commonly reported tumors.

Statement of the Problem: Head and neck cancer treatment has provided better cure and survival rates but the patient’s quality of life is still an issue. To verify the correlation between the three most used instruments for evaluating the quality of life of head and neck cancer patients. The study evaluated patients treated for head and neck cancer at the Mato Grosso Cancer Hospital, Cuiabá, MT, Brazil. The variables age, gender, cohabitation status, education, religion, smoking, ethnicity, tumor location and histological type and treatment modality were collected. The patients quality of life was assessed by the Functional Assessment of Cancer Therapy Quality of Life Measurement System (FACT-H&N), University of Washington Quality of Life Questionnaire (UW-QOL), and EORTC QLQ-C30/EORTC QLQ-H&N35 of the European Organization for Research and Treatment of Cancer. The study population consisted of 33 individuals with a mean age of 63.42 ± 11.25 years; 69.70% were males; 54.55% had no partner; 45.45% had only elementary education; 87.9% followed a religion; 84.38% were smokers and 87.50% alcoholics. Squamous cell carcinoma responded for 78.79% of the cases and palate/oropharynx and mouth floor (21.21% each) were the most affected sites. All patients underwent radiotherapy, 90.91% chemotherapy and 63.64% surgery. On the analysis of quality of life, shoulder (UW-QOL), social performance (EORTC QLQ-C30/QLQ-H&N35) and overall well-being (FACT-H&N) had the highest scores while saliva (UW-QOL), nausea and vomiting (EORTC QLQ-C30/QLQ-H&N35) and emotional well-being (FACT-H&N) had the lowest scores. A positive correlation was found between the questionnaires for the patient's overall quality of life and the domains: Pain, Appearance, Activity, Deglutition, Chewing, Speech, Taste, Saliva, Mood and Anxiety. Given the correlation between the questionnaires, the selection of the instrument for future research involving head and neck cancer patients’ quality of life should consider the specific aspects to be evaluated.