جستجوی مقالات مرتبط با کلیدواژه « permethrin » در نشریات گروه « پزشکی »

This study aimed to compare the impact of 5% permethrin cream combined with oral doxycycline with 1% ivermectin cream combined with oral doxycycline in treating patients with papulopustular rosacea.

This study was a single-blind clinical trial on papulopustular rosacea patients at Isfahan teaching hospitals. Patients were randomly divided into two groups: one receiving 5% permethrin cream with oral doxycycline and the other receiving 1% ivermectin cream with oral doxycycline. Inflammatory lesion count, IGA Score, and VAS Score were compared at 0, 6, and 12-week intervals.

All 40 patients involved in the study were female, with an average age of 42.53 ± 10.4 years. The findings revealed a significant decrease in the average number of inflammatory lesions over time in both treatment groups (P < 0.05). Nevertheless, there was no notable variance in the number of inflammatory lesions over time between the two groups (P = 0.098). Additionally, the average IGA Score in both treatment cohorts significantly reduced as time progressed (P < 0.05). However, there was no significant contrast in IGA Score changes over time between the two treatment groups (P = 0.129). Patient satisfaction levels did not differ significantly between the two groups (P = 0.635).

The results indicated that both treatments were effective in decreasing the disease severity, reducing inflammatory lesions, and lowering the IGA Score. Nevertheless, no substantial superiority of one treatment over the other was observed in this study.

Head lice (Pediculus capitis) infestation is considered an important hygienic problem in developing countries. The aim of study was to compare 1% permethrin shampoo and 4% dimethicone lotion effects for treatment of infected head lice students in primary girl schools in Gotvand County, Khuzestan province.

The studied population was first- to sixth-grade students in elementary schools. Positive cases with head lice after identification (304 persons) were randomly divided into two treatment groups. Permethrin shampoo and dimethicone lotion were allocated for the first and the second groups, respectively. The drug therapeutic effects were studied after 7, 14 and 21 days after treatment. Data were analyzed by Chi-square test using SPSS software.

Ethical Considerations: 

This study was approved by the Ethics Committee of Hamadan University of Medical Sciences (Code: IR.UMSHA.REC.1399.778).

In total, 304 students participated in the study. The age of students ranged between 7 and 12 years which 47.7% of them were between 7 and 8 years. Also 60.9 and 39.1% of them were in urban and rural schools, respectively. The drug effectiveness were 46.1, 69.5 and 100, and 77.6, 85.3 and 100% for permethrin and dimethicone in the first, second and third intervals after treatment, respectively. There was a significant difference between the effect of drugs in the first interval (P = 0.00) after treatment but there was not a significant difference between the second (P = 0.084) and the third (P = 0.43) intervals after treatment.

It is recommended the use of dimethicone lotion and permethrin shampoo as the first and second option, respectively in eliminating the head lice infestation in primary girl schools.

Nowadays, there are many challenges in the treatment of head lice infestation and the efficacy of anti-lice products is a very important factor. The aim of this study was to determine the effectiveness of using vinegar before and after application of permethrin shampoo for the treatment of head lice infestation in the elementary school students in Qom Province.

Our study inclueded 200 female students infested with head lice referring to two comprehensive urban health centers of Qom University of Medical Sciences from September to February 2020. The patients were between 13 and 17 years of age. Using blocked randomization with randomly selected block sizes, the patients were treated with either application of vinegar before or after using 1% permethrin shampoo. Removal of adult human head lice, nymphs, and nits were considered as the outcome of the treatment methods.

The current standard treatment method proposed by the Ministry of Health (use of vinegar after applying permethrin shampoo 1%) resulted in the treatment of the infestation in 45% of cases. But the experimental treatment method (using vinegar before applying permethrin shampoo 1%) led to successful treatment of 79% of the participants and showed a high Odds Ratio (OR = 4.6 CI = 2.5-8.5 p = .000).

This study did not approve the current standard treatment method of the Ministry of Health (use of vinegar after consuming permethrin shampoo 1% for removal of head lice infestation). Therefore, we recommend application of vinegar before using permethrin shampoo 1%.

Head lice is a worldwide parasitic disease that can be considered a threat to public health. The majority of its prevalence is among children aged from 6 to 11 years. Due to students’ low attention to personal hygiene tips, and presence in populated places such as schools, they are more prone to head lice infestation; thus, studying this disease among students is a hygienic priority. The current study was undertaken among primary girl students in Doroud County with the aim to determine the prevalence of head lice infestation and its relations with epidemiologic factors and to evaluate the treatment efficay of permethrin shampoo 1% and dimethicone.

The present study was performed in two phases: observational (cross-sectional) and interventional (clinical trial). Five schools were selected from five geographical areas for sampling. Other information was collected from student records or by direct inquiry. Eighty girls infested were randomly allocated in two groups and received either one of the mentioned treatments. The results of the interventions were evaluated on days 7 and 14.

The prevalence of head lice infestation was10.3%. The most involved group (40 %) were students of third grade. The father’s education and shower times per week showed significant effects among epidemiologic factors (p value = 0.05). The outcome of treatment in the first week did not show a significant difference between the groups. Treatment with dimethicone lotion in the second week (p value = 0.025) and in general during two weeks (p value = 0.006) was more effective in removing the head lice than permethrin shampoo.

Head pediculosis is more prevalent among girl students whose fathers are less educated and take less showers in a week. Thus it is crucial to deal with head lice by social health education among families. In addition, dimethicone lotion is more effective than permethrin shampoo in eradicating this external parasite.

Permethrin is a drug used to cure pediculosis known as head lice. This drug is available in two forms: 1) permethrin topical cream 5%, 2) permethrin shampoo 1%. The aim of this study was to find a method and define the simultaneous cis and trans isomers for permethrin, methyl paraben, propyl paraben and butylated hydroxytoluene in topical cream 5% using the method high-performance liquid chromatography.

In order to analyze the measuring method, 5 concentration of samples and concentration of permethrin 5% have been provided, which each were injected to HPLC machine. Three times and the validity index such as selectivity, linearity, accuracy and correctness is analyzed.

According to the results of chromatographs, selectivity, linearity, accuracy and correctness were considered as acceptable areas.

Regarding the point that there is no pharmacopeia method to define the ingredients in permethrin cream simultaneously, it is so important to find an efficient analysis method to identify the peak of all ingredients in one chromatogram, considering the industrial production, time saving and increased efficiency of production units. Meanwhile the method was validated to insure that the results are correct, accurate, assurable and repeatable.

Today personal protection measures against mosquitoes and other medically important arthropods have a significant role in integrated vector management programs. Personal protection technologies such as insecticide-treated clothes and nets are some of the most effective tools against mosquitoes. Permethrin, as a synthetic pyrethroid insecticide, with features such as having a knockdown, repellency and residual activity, and low human and mammalian toxicity, is widely used for impregnation of fabrics and clothes. The dose required is 1250 mg/m2, which has not caused toxic effects in users. Many methods have been developed to impregnate fabrics and clothes with permethrin or similar compounds. However, new impregnation methods such as polymer-coating and microencapsulation technologies which may prolong the activity of insecticides on clothing are currently under development. These methods have the advantage of helping to overcome the inevitable reduction in efficacy over time that occurs as a result of washing, ultraviolet light exposure, and the normal wear and tear of the fabric. The aim of this review is to investigate the evidence base for the use of insecticide-treated clothing and military uniforms for protection against bites from arthropods and its effect on arthropod-borne pathogen transmission. Although insecticide-treated clothing can provide some protection against biting, few studies have shown 100% protection against bites using insecticide-treated clothing alone, and in most cases the protection rate has been under 100%. On the other hand, studies conducted on pathogen transmission rate are few, and the level of protection provided varies according to the vectors, impregnated fabrics and location. In general, there is reliable evidence which suggest that impregnated fabric can provide effective protection against insect bites, and providing relative protection against vector-borne diseases in bites. Nonetheless, simultaneous use of impregnated clothes and insect repellents on the skin can provide complete protection against bites and consequent disease. This approach is recommended for protection of high-risk personnel such as soldiers and outdoor workers, as well as travelers and tourists and, to protect against biting insects and vector-borne diseases.

Head lice (Pediculus humanus capitis) are obligate ectoparasites of mankind, and are mainly transmitted head to head directly from one person to another. Human head lice treatment is faced with some challenges such as lack of complete treatment and the need for treatment repeatedly. The aim of this study was to evaluate the efficacy of two pediculicide products (substances used to treat human head lice infestation); 1% permethrin shampoo and 4% dimethicone lotion.
In this clinical trial, 140 cases of head lice infested people that were referred to the urban comprehensive health centers of Qom provincial health center related to Qom University of Medical Sciences and Health Services, Iran, from April to March 2017. The cases randomly were treated with two pediculicide products; 1% permethrin shampoo and 4% dimethicone lotion. The outcome of the treatment included removal of adult human head lice, nymphs, and nits in confirmed human cases at 14 and 21 days after starting treatments were considered.
The success rate of human head lice infestation treatment in case of double use (at one-week intervals) with 1% permethrin shampoo and 4% dimethicone lotion was 65.7% and 62.9%, respectively. There was no statistical significance between the therapeutic effects of the two above-mentioned methods (odds ratio=1.22, P=0.59, CI=0.6-2.5). While the recovery rate of men compared to women was 3.8 (P=0.036), it was 3.1 (P=0.05) for housewives compared to students, and in families with one case compared to ones with more than one patient, this rate was found to be 3 (P=0.034). Family size was one of the most important variables that had a significant effect on the therapeutic rate of 1% permethrin shampoo and 4% dimethicone lotion.
The findings of this study do not support the reduction in efficacy of 1% permethrin shampoo and 4% dimethicone lotion as pediculicide products.

Head louse (Pediculus humanus capitis) is one of the most important parasites in humans and applying permethrin is the standard method for its control. Continuous application of this chemical increases the probability of permethrin resistance and gradually the addition of alternative substances is necessary. The aim of this study was evaluation of the efficacy of eucalyptus and cinnamon essential oils in head lice treatment compared to permethrin.
The essential oils of Eucalyptus globules and Cinnamomum zeylanicum were extracted using a hydrodistilation method and their components were identified via gas chromatography. In the single-blind clinical trial, 95 infested cases residing in Zanjan were categorized into groups of 34, 31 and 30, receiving eucalyptus, cinnamon and permethrin treatment respectively. The lice infestation and hatching rate of nits were investigated before and after the intervention.
The major components of eucalyptus and cinnamon were 1,8-cineole, alpha-pinene, cinnamaldehyde, and 2-propenal, 3-phenyl respectively. The hatching rate of nits was equal in study groups before the intervention. Eucalyptus shampoo showed a higher therapeutic effect than the other substances (p 0.28).
Eucalyptus essential oil had a greater therapeutic effect on head lice. This compound is recommended as an alternative to permethrin or for use in combination with permethrin in the head lice control program.

Human flea is assumed as the most dominant ectoparasite associated with transmitting diseases via biting humans. Insecticides are widely employed to curb this vector. Assessment of susceptibility level of populations to various pesticides is necessary for taking appropriate control measures. Subsequent to collection of human flee from indoor areas of Khodabandeh and Mahneshan located in Zanjan province from August 2013 to November 2014, they were kept under standard laboratory conditions. The samples were exposed to inconsistent doses of Permethrin and Lambdacyhalothrin and consequently their mortality rates were assessed after 24 hours. Out of 1074 collected fleas, 88.1% were Pulex irritans, 7.2% Ctenocephalides cani and 4.7% C. felis. Bioassay[s1] results gave evidence to homogeneity of study population. LD50 values for permethrin and lambdacyhalothrin were 288.40 – 295.15 µg/ cm2 and 21.87 – 24.54 µg/cm2, respectively. High levels of LD50 values to pyrethroides of human flea in the studied area indicated the requirement of more attention of health workers to control the vector and Further[s2] research is necessary to assess the resistance status of human flea to alternative effective insecticides.

Background and Scabies is caused by a mite called Sarcoptes scabiei and can be spread from person to person through skin contact. In this study, we have analyzed the effect of Malathion lotion 0.5% and compared that with the effect of Permethrin cream 0.5%. In a randomized clinical trial 60 patients were divided into two groups to receive either Permethrin cream 5% or Malathion lotion 0.5%. Both groups were monitored every two weeks for one month. The qualitative data of both groups were compared using student t-test and chi-square test was applied to analyze the qualitative data. There was no significant difference between the two groups in number of lesions at the begging of the study (P=0.1503). Also, no significant difference was seen in weeks two and four. But Malathion lotion was found to be more efficient than Permethrin (P=0.0163) in reducing the number of lesions; although the results were better in week four, but the difference was not significant (P=0.2940). This study showed high efficacy of Malathion 5% in treating scabies.

Reportedly, Prevalence of Pediculosis Capitis in some parts of the country, including Qom province, has been increasingly soaring in recent years. This has caused some problems in pediculosis care namely repeated treatment or even persistent infestation at times. Present study was to investigate therapeutic efficacy of 1% permethrin in treatment of head louse (Pediculus Humanus var Capitis) and its influential factors in Qom province in 2013. Materials and In this trial, 378 head lice infested people with Permethrin shampoo 1% were treated and a week after the treatment period, were examined. After that, infested people were treated again and this trend will continue up for 4 courses of treatment. Of total cases who received the 1% permethrin treatment, 58.2% of cases were treated after one period of therapy. Those who were treated after two, three, and four periods of therapy were 35.4%, 2.4%, and 1.6% of the total cases respectively. Surprisingly, 2.4% of cases did not show any sign of treatment. Totally speaking, 93.6% of cases were free of infestation after one or two periods of treatment. Findings revealed that there was a relationship between infestation density within household, mother's education level, and increase in duration of treatment. Odds of increase in treatment duration among households with 1-2 infested persons were 2.39 (OR=2.39, P= 0.000), and with 3 infested persons were 5.23 (OR=5.23, P= 0.000) times higher than households with no infested person. People of over 20 years old (comparing to under 10 years old) had a higher odds of increase in treatment duration (Or=2.46, P=0.04). Density of infestation and low level of parental education are of factors disposing head louse infested cases to repeated periods of treatment with 1% permethrin. Therefore, treatment of these households should pay more attention to sever education and follow-up.