جستجوی مقالات مرتبط با کلیدواژه "radio-protector" در نشریات گروه "پزشکی"

Radiotherapy treats over 70% of thoracic tumours; however, the technique frequently causes radiation-pneumonitis. Luteolin exhibits anti-inflammatory properties and inhibits chemotaxis release. The radio protective effects of luteolin on γ-rays-induced pneumonitis in rats were evaluated.

Thirty-two rats were distributed into four groups. Rats were exposed to 8.5Gy-γ-rays then, treated with or without luteolin for 20-days. Oxidative-stress, antioxidant, anti-inflammatory markers levels, collagen content, and histopathological structures were evaluated in lung tissue.

Increased reactive oxygen species (ROS) production and oxidative stress after irradiation were down-regulated by luteolin treatment, demonstrating luteolin’s antioxidant and anti-inflammatory properties. Luteolin attenuated lung histopathological changes which represented by desquamation of bronchiolar epithelia with pre-bronchiolar leukocytic infiltrations, proliferation of pneumocytes type ІІ, emphysema and collapse induced by γ-rays.

The current study found, for the first time, that luteolin has a protective effect on whole body γ-rays-induced early lung injury in rat model.

Hesperidin is a bioflavonoid glycoside mainly found in citrus fruit and has been shown radio-protective potential in various measurement systems.

In this article aims to investigate the radio-protective effect of hesperidin on the liver of Sprague Dawely rats.

In this clinical study, 40 male rats were selected randomly and divided into 8 groups. Group 1 did not receive radiation and hesperidin (sham control). Group 2 received only 100 mg/kg body weight (b.w) of hesperidin for 7 consecutive days (HES group); group 3 exposed to dose of 2Gy whole body gamma radiation (2Gy group), and group 4 and 5 received 50 and 100 mg/kg b.w of HES for 7 consecutive days before 2 Gy gamma radiation, respectively.Group 6 exposed to dose of 8Gy gamma radiation (8Gy group); group 7 and 8 received 50 and 100 mg/kg b.w of HES for 7 days before 8Gy gamma irradiation, respectively. Histopathological evaluation was perfomred 24 hours after radiation.

Administration of hesperidin (50 mg/kg b.w, 7 days) before 2Gy of gamma irradiation led to remove inflammatory mononuclear cells in the portal space. Microscopic findings in the groups receiving two doses of hesperidin (50 and 100 mg/kg b.w, orally, 7 days), before 8Gy of gamma radiation, were similar in a way that extreme dilation of central veins to be seen, however, there was no capillarization.

HES can be offered as a suitable radio-protector in radiotherapy patients and radiation workers.

Considering the remarkable application of radiotherapy in the treatment and diagnosis of various diseases and even nuclear war, it is important to protect healthy tissues and people at risk from the radiation. Currently, there is no ideal and safe radioprotective agent available and we are seeing a great effort to find these agents from natural sources. Phenolic compounds, as well as flavonoid, are presented widely as the second metabolite in plants and they have been considered for investigation according to their benefits for human health, healing and preventing many disorders. The major bioactive benefits of flavonoids include antioxidant, anti-inflammatory, anti-tumor, anti-aging, anti-bacterial and viral, neuroprotection and radioprotective effects. Their lower toxicity and oral administration have made it suitable for radiotherapy patient, radiation, military forces, and even the general public. This review attempts to provide a summary of the main molecular mechanisms involved in flavonoid radio-protective effects. Data of these studies will provide a comprehensive perspective to flavonoids and can help to optimize their effects in radioprotection procedures.