جستجوی مقالات مرتبط با کلیدواژه "resistance index" در نشریات گروه "پزشکی"
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Fetal hemodynamic changes can occur immediately following invasive chorionic villus sampling (CVS). We decided to study the possible effect of CVS on fetal heart rate (FHR), and uteroplacental resistance index (RI) changes using color Doppler ultrasound. Thirty-five pregnant patients with a gestational age of more than 12 weeks were included. Trans-abdominal CVS was done to assess the possibility of thalassemia. Before and after the CVS, color Doppler ultrasound was done to measure FHR and uteroplacental RI. Mean (SD) values for FHR before and after the CVS were 175.22 (±9) and 173.62 (±9.94) beats per minute, respectively; P=0.18. Mean (SD) uteroplacental RI before the CVS was 0.79 (0.07) which significantly increased to 0.82 (0.08); P=0.03. We observed a significant increase in resistance of blood flow in placental circulation after CVS. However, no significant change was observed regarding FHR after CVS.
Keywords: Chorionic villus sampling, Fetal heart rate, Resistance index, Doppler -
Background
Varicocele is one of the leading causes of infertility in men. Resistance index (RI) in testis is a parameter indicating parenchymal perfusion and microvascular functions. Increased RI in the testis of patients with varicocele might be a sign of impairments in microvascularization and a significant decrease in testicular perfusion. In the present study, RI in capsular and intraparenchymal testicular arteries was evaluated in patients with varicocele who underwent varicocelectomy.
MethodsThis prospective cohort study was performed in 2019-2020 in Guilan, Iran. Sixty-six patients were included. Semen analysis was also done before surgeries. Patients with at least one disorder in semen analysis entered the study. RI in testicular arteries was measured by an experienced radiologist before surgeries. Six months after varicocelectomy, all patients underwent the same semen analysis and ultrasound imaging. Data were analyzed using SPSS software. The tests for analysis included McNemar Test and Wilcoxon and p<0.005 was considered as the significance level.
ResultsAccording to the results, 42 patients (63.6%) had positive changes in sperm analysis after surgeries. Sperm analysis showed a significant increase in number, concentration, morphology, and motility of sperm after surgeries (p<0.001). Further measurements of capsular and intratesticular RI in all patients also indicated a significant decrease (p<0.001).
ConclusionIncreased RI might be associated with impaired microperfusion in testis followed by impairments in semen. Moreover, mean capsular and intratesticular RI in patients decreased after surgeries and this decrease was significantly more in patients who had improvement in their semen parameters.
Keywords: Color Doppler ultrasound, Resistance index, Semen analysis, Varicocele, Varicocelectomy -
مجله پزشکی دانشگاه علوم پزشکی تبریز، سال چهل و یکم شماره 1 (پیاپی 139، فروردین و اردیبهشت 1398)، صص 108 -114زمینهمصرف بی رویه آنتی بیوتیک های بتالاکتام منجر به ایجاد گروهی از آنزیم های بتالاکتامازی به نام بتالاکتامازهای طیف گسترده (ESBL) شده است. تولید این آنزیم ها سبب ایجاد مقاومت نسبت به سفالوسپورین های نسل سوم و هیدرولیز مونوباکتام ها می گردد .بیماری های عفونی و درمان آنها از مشکلات اساسی در زندگی بشری می باشند وعلیرغم گذشت سالیان متمادی از آغاز عصر شیمی درمانی ضدمیکروبی، در سراسر جهان مشکلات عدیده ای را ایجاد نموده است. این مطالعه جهت بررسی الگوهای حساسیت آنتی بیوتیکی و بررسی حضور ژن blaCTX-M-1 در ایزوله های اشریشیاکلی جداسازی شده از نمونه های بالینی در آزمایشگاه مرکزی شهر تبریز انجام شد.روش کارتعداد 100 ایزوله در طی یک ماه از آزمایشگاه مرکزی شهر تبریز جمع آوری گردید. ایزوله های اشریشیاکلی توسط تست های روتین باکتریولوژیک شناسایی و به روش Kirby-Bauer با استفاده از آنتی بیوتیک های آموکسی سیلین، سفتازیدیم، سفوتاکسیم، سیپروفلوکساسین، جنتامایسین، ایمی پنم و نیتروفورانتوئین آنتی بیوگرام گردیدند. تست تاییدی به روش دیسک ترکیبی (Combined disk test) انجام شد. در نهایت با استفاده از روش PCR ژن blaCTX-M-1 تحت بررسی قرار گرفت.یافته هااز 100 ایزوله اشریشیاکلی تعداد 17 ایزوله (17%) حاوی ژن blaCTX-M-1 بودند. همه ایزوله ها حساس به نیتروفورانتوئین و 79% ایزوله ها مقاوم به آموکسی سیلین و82% ایزوله ها ESBL مثبت بودند.نتیجه گیریبا توجه به نتایج مطالعه حاضر، ژن مولد بتالاکتاماز blaCTX-M-1 که تنها جزیی از خانواده بزرگ بتالاکتاماز وسیع الطیف می باشد، در 17% ایزوله های اشریشیاکلی شناسایی شد که این نتایج بیانگر وجود کلون های مولد دیگر ژن های بتالاکتاماز وسیع الطیف نیز می باشد.کلید واژگان: اشریشیاکلی, اندیکس مقاومت آنتی بیوتیکی, ژن blaCTX-M1, واکنش زنجیره ای پلیمراز (PCR)BackgroundOveruse of beta lactam antibiotics have led to emergence of Extended spectrum beta lactamases (ESBLS). Production of these enzymes can cause resistance against third generation cephalosporins and hydrolysis of monobactams. Treatments of infectious diseases are difficult and in spite of antimicrobial chemotherapy, there are still some difficulties. This study was conducted to investigate antibiotic susceptibility of and search for presence of blaCTX-M-1 gene in clinical E. coli isolates collected from central laboratory of Tabriz.MethodsOne hundred E. coli isolates were collected from central laboratory of Tabriz. Antibiotic susceptibility tests were carried out according to Kirby- Bauer method using amoxicillin, ceftazidime, ciprofloxacin, cefotaxime, imipenem, gentamicin and nitrofurantoin antibiotics. Confirmatory tests were also performed using combined disk test. Finally PCR was used for detecting blaCTX-M-1gene.ResultsSeventeen out of 100 E. coli isolates contained blaCTX-M-1 gene. All of the isolates were sensitive to nitrofurantoin, while 79% of our isolates were resistant to amoxicillin and 82% were recorded an ESBL producers.ConclusionSeventeen percent of E. coli isolates contained blaCTX-M-1gene as a group of ESBL gene indicating presence of other groups of ESBL producing genes which require further studies.Keywords: Escherichia coli, resistance index, blaCTX-M-1gene, Polymerase chain reaction (PCR)
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BackgroundTo determine whether the phosphodiesterase type 5 inhibitor, Sildenafil citrate, affects uteroplacental perfusion.Materials And MethodsBased on a randomized double-blinded and placebo-controlled trial, forty one pregnant women with documented intrauterine growth retardation at 24-37 weeks of gestation were evaluated for the effect of a single dose of Sildenafil citrate on uteroplacental circulation as determined by Doppler ultrasound study of the umbilical and middle cerebral arteries. Statistical analysis included χ2test to compare proportions, and independent-samples t-test and paired student’s t-test to compare continuous variables.ResultsSildenafil group fetuses demonstrated a significant decrease in systolic/diastolic ratios (0.60 [SD 0.40] [95% Cl 0.37-0.84], P=0.000), and pulsatility index (0.12 [SD 0.15] [95% Cl 0.02-0.22], P=0.019) for the umbilical artery and a significant increase in middle cerebral artery pulsatility index (MCA PI) (0.51 [SD 0.60] [95% Cl 0.16-0.85], P=0.008).ConclusionDoppler velocimetry index values reflect decreased placental bed vascular resistance after Sildenafil. Sildenafil citrate can improve fetoplacental perfusion in pregnancies complicated by intrauterine growth restriction. It could be a potential therapeutic strategy to improve uteroplacental blood flow in pregnancies with fetal growth restriction (FGR).Keywords: Cerebroplacental ratio, Doppler flow velocimetry, fetal growth restriction, pulsatility index, resistance index, systolic, diastolic ratio
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Relationship between Intra-renal Arterial Resistance Index (RI) and Albuminuria in Diabetic PatientsIntroductionDiabetic nephropathy is a major diabetes complication. Arterial resistance index (RI) may predict deterioration in kidney function. This study was designed to compare renal arterial RI in different stages of renal function according to glomerular filtration rate (GFR), serum creatinine level and proteinuria.Materials And MethodsIn a cross-sectional study on 81 diabetic patients in three groups (Without albuminuria, with microalbuminuria, with macroalbuminuria), pulsatile Doppler ultrasonography was performed to measure intra-renal arterial resistance index and find the association of this parameter with features of diabetic nephropathy. Data was analyzed using SPSS (ver. 16).ResultsSerum creatinine, GFR and proteinuria were significantly different among three groups. RI was highest in the group with macroalbuminuria and the difference among three groups was statistically significant. (P value<0.001) RI was correlated with serum creatinine, GFR and proteinuria.ConclusionHigher RI correlates with higher proteinuria in diabetic patients.Keywords: Diabetic Nephropathy, Resistance Index, Creatinine
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Background
Doppler indices of umbilical artery are used as indicator of fetal well being.
ObjectiveTo compare Doppler parameters of umbilical artery including pulsatility index (PI) and resistance index (RI) in patients with preeclampsia with those of normal pregnancies and to evaluate the diagnostic characteristics of these parameters in preeclampsia.
Materials And MethodsIn a case control study, umbilical artery pulsatility and resistance indices were calculated at a free loop of umbilical cord in 25 preeclamptic patients and 75 uneventful pregnancies. Measurements were compared and diagnostic characteristics of the indices were determined.
ResultsMean of pulsatility and resistance index were significantly higher in preeclampsia patients than the control group. Besides, patients with severe preeclampsia showed significantly higher values of PI and RI in comparison to those with mild preeclampsia. For PI, the cut-off of ≥0.98 yielded the highest sensitivity and specificity. Also, RI of 0.64 acquired a sensitivity of 100% and specificity of 44%.
ConclusionUmbilical artery pulsatility index and resistance index increase in preeclampsia and these changes tend to be greater in severe preeclampsia. Umbilical artery PI and RI seem to be more appropriate in excluding preeclampsia rather than confirming it, and we propose the cut-off values of 0.98 for PI and/or 0.64 for RI, to rule-out the disease.
Keywords: Preeclampsia, Umbilical artery, Pulsatility index, Resistance index -
مقدمه
دستگاه های سونوگرافی جدید امکان ارزیابی بهتر شرائین ورتبرال را فراهم نموده اند و هدف از این مطالعه تعیین مقادیر نرمال معیارهای همودینامیک در شرائین ورتبرال افراد مسن سالم می باشد.
مواد و روش هادر این مطالعه 31 فرد سالم با محدوده سنی 60 تا 96 سال تحت بررسی سونوگرافی داپلر رنگی قرار گرفتند و در این افراد قطر و نیز معیارهای مربوط به مشخصات همودینامیک در شرائین ورتبرال بررسی و ثبت شد.
یافته های پژوهشدر تمامی موارد امکان مشاهده قسمت دوم شرائین ورتبرال مقدور و مشاهده مبدا آن در طرف راست در 72 درصد و در طرف چپ در 59 درصد افراد ممکن شد. متوسط قطر شریان ورتبرال راست 56/0±24/3 میلی متر و چپ 67/0±52/3 میلی متر، اندکس مقاومت در طرف راست 08/0± 71/0 و در طرف چپ 06/0±69/0 بود و اختلاف معنی داری بین دو طرف از نظر قطر و اندکس مقاومتی مشاهده نشد (078/0P=). حداکثر سرعت سیستولی در طرف راست 71/12±77/35 سانتی متر در ثانیه و در طرف چپ 71/12±29/36 سانتی متر در ثانیه بوده و اختلاف معنی داری بین دو طرف وجود نداشت (093/0P=).
نتیجه گیری نهاییاین مطالعه و مقادیر ارائه شده در آن می تواند در افتراق یافته های نرمال از حالات مرضی در شرائین ورتبرال در افراد مسن کمک نماید.
کلید واژگان: شریان ورتبرال, سونوگرافی داپلر رنگی, حداکثر سرعت سیستولی, اندکس مقاومتIntroductionThe introduction of color Doppler Ultrasonography has improved the evaluation of vertebral arteries. This study was designed to determine normal values of hemodynamic parameters in second segment of vertebral artery in healthy old people. Materials &
MethodsWe performed a prospective study in 31 healthy adults from 60 to 96 years old. Angle corrected flow velocities and luminal diameters were measured and waveform parameters calculated in all vertebral arteries.
ResultsIt was possible to visualize V2 Segment in 100% and origin of right VA in 72% and origin of left VA in 59% of them. Mean diameter of right VA was 32.4± 0.56 mm while it was 3.52± 0.67 mm for the left VA. The resistance index in right VA was 0.71±0.08 and it was 0.69±0.06 in the left VA.There was no significant differences between the two sides. Peak systolic velocity was 35.77±12.71 cm/s on the right and 36.29±12.71 cm/s on the left. Accordingly, no differences were observed between the two sides.
ConclusionThis study and its presented reference values can lead to better differentiation between normal and pathologic findings in vertebral arteries among old people. Nevertheless, further studies are needed to determine the normal and pathologic values of vertebral arteries.
Keywords: Vertebral Artery, Doppler Sonography, Peak Systolic Velocity, Resistance Index
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