جستجوی مقالات مرتبط با کلیدواژه « restenosis » در نشریات گروه « پزشکی »

Surgical methods such as coronary artery bypass grafting and percutaneous coronary interventions (PCI) are widely used along with traditional conservative therapy in the treatment of coronary artery disease. The disease outcome directly depends on timely diagnosis and treatment. A significant role in predicting the effectiveness of treatment is given to personification of treatment and management of the patient. In this case, the determining component is its individual genetic status.

The study groups included persons of Kazakh nationality which identify themselves, their biological parents, and biological grandparents on the maternal and paternal side as Kazakh. Research groups included 108 people at the age from 45 to 65 years of both sexes. Blood samples genotyping was carried out by PCR using highly specific TaqMan samples. Thermo Fisher cloud application was used for genotypes determining on the base of an automatic algorithm.

The article presents the results of the evaluation of gene polymorphisms associated with coronary artery restenosis in a population of Kazakh nationality. 3 SNPs were determined when searching for an association with stenting due to coronary artery thrombosis: rs7543130 (p=0.009324), rs6785930 (p=0.016858), rs7819412 (p=0.061325).

Four polymorphisms associated with the risk of developing coronary heart disease were revealed during the study of polymorphisms among the people of the Kazakh population. Three SNPs were determined when searching for an association with stenting due to coronary artery thrombosis. It should be noted that the Bonferonni correction for multiple comparisons did not reveal significant polymorphisms associated with coronary artery disease, which requires further research with more quantity of samples.

We aimed to investigate the effect of copper stainless steel on apoptosis of vascular smooth muscle cells in coronary artery.

The study was carried out in 2019 at Hubei University of Medicine, Xiangyang, China. The rat coronary artery smooth muscle cell was used for cell resuscitation and culture. MTT method was used to visualize cell growth curve and to detect the cell survival and growth. The incubated cells were randomly divided into copper-containing stainless-steel group, ordinary stainless-steel group, and control group. The cells were made into single cell suspension, which were intervened by experimental group and incubated in incubator with CO2 for 48 hours. TUNEL method was used to detect the apoptosis. The number of apoptotic cells in five high power fields (×200) was counted. The expression of Fas protein in three groups of cells was detected by Western blot.

The growth curves of rat coronary artery smooth muscle cells showed that the OD value of the cells reached the plateau 7 days after inoculation, indicating that the cells grew well. TUNEL staining showed the apoptosis in all three groups. The apoptotic index in copper-containing group was significantly higher than that in common stainless-steel group (P <0.01). The results of the Fas protein expression level through Western blot showed that the level in the copper-containing group was significantly higher than that in the common stainless-steel group (P<0.01).

Copper-containing stainless steel can promote apoptosis of coronary artery smooth muscle cells. The material could prevent stent restenosis.

The number of individuals with a history of coronary artery bypass graft surgery (CABG) who may require a second revascularization intervention is growing. We aimed to identify the predictors of revascularization in patients with a history of CABG who were referred for conventional coronary angiography due to acute coronary syndrome (ACS) or stable angina. Data of 536 patients (74% males) who had a previous history for CABG and were referred for coronary angiography due to ACS or stable angina were included in the study. Demographic, clinical, diagnostic, and angiographic characteristics of the patients were retrieved from our institutional databank and patient’s records. Based on the final recommendation, the patients were divided into two groups for either medical treatment or revascularization and compared for the study variables as well as identifying the predictive factors for the second revascularization. From a total of 536 patients, 194 (36.1%) patients were advised to continue medical therapy, and the rest were referred for revascularization (repeat CABG or percutaneous coronary intervention). Elapsed time after CABG for <1 year or >10 years (P = 0.016), use of diuretics (P = 0.002), and presenting in an inpatient setting (P = 0.009) were significant predictors for the feasibility of second revascularization treatment, using multiple regression analysis. Elapsed time after CABG and some other clinical factors can predict the feasibility of the second revascularization in patients with a history of CABG and new onset of cardiac symptoms.

Diagnostic value of multi-slice computed tomography (MSCT) for detecting in-stent restenosis in comparison with conventional coronary angiography remained uncertain. The present study aimed to determine the value of MSCT for detecting in-stent restenosis.

This historical cohort study was included 226 patients with the history of percutaneous coronary intervention from 2000 to 2014 that referred to MSCT Unit at Alzahra Heart Center in Isfahan. The subjects were followed-up by telephone with regard to performing coronary angiography up to 3 months after MSCT and their status about cardiac events.

Among all participants, 63 stents (27.9%) underwent coronary angiography up to 3 months afte r MSCT that 2 stents in left circumfl ex artery (LCX) assessment, 2 in left anterior descending (LAD) assessments and none in right coronary artery (RCA) assessment were uninterpretable. Sensitivity, specifi city, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MSCT was 92.9%, 66.6%. 92.9%, 66.6%, and 88.2%, respectively for detection of occlusion in LCX stents, 100%, 100%, 100%, 100%, and 100%, respectively for detection of occlusion in LAD stents, and 80.0%, 0.0%, 80.0%, 0.0%, and 66.7%, respectively for detection of occlusion in RCA stents. Overall, MSCT had sensitivity of 93.8%, specifi city of 70.0%, PPV of 93.8%, NPV of 70.0%, and accuracy 89.7% for detection of coronary stent restenosis.

MSCT has high diagnostic value for detecting in-stent restenosis. Diagnostic accuracy of MSCT for detecting stent restenosis is considerably different between the coronary arteries with the highest diagnostic values for LAD and the lowest diagnostic values for RCA.

The incidence of restenosis in patients suffering from coronary artery disease after undergoing angioplasty is of paramount importance. Accordingly, this study aimed to investigate factors affecting the time of the first incidence of restenosis in patients undergone angioplasty in the city of Zanjan, Iran.

This retrospective cohort study was conducted on 421 patients who referred to Ayatollah Musavi hospital in Zanjan for angioplasty during 2009 to 2012. The time of the incidence of restenosis after angioplasty constituted the dependent variable of the study. Independent variables of the study included signs of diabetes, hypertension, hyperlipidemia, kidney disease, carotid stenosis, lung disease, anemia, angina history, and MI. The Cox regression model with the significance level of 0.05 was deployed for the statistical analysis.

According to the Cox regression model, hazard ratio of the first incidence of restenosis in patients with hypertension and angina was 22.8% and 29.5% less than other patients, respectively. However, hazard ratio of the first incidence of restenosis was 7.4 times more in patients suffering from carotid stenosis than other patients (p

The results of this study revealed that as time goes on, the risk of the incidence of restenosis in angioplasty patients increases such that patients’ survival decreases dramatically after a year. To determine the role of effective factors on the incidence of restenosis, conducting a prospective interventional study is highly recommended.

A great revolution happened in coronary intervention after the invention of drug eluting stents (DES). Different types of DES have been made. Stents with biocompatible polysulfone polymer and paclitaxel drug is newly introduced. In this study we aimed to evaluate the efficacy of this new drug eluting stent. All consecutive patients underwent coronary angioplasty with paclitaxel eluting stents from January to March 2009 were enrolled. Data was collected in answer sheath and analyzed with SPSS 18. One hundred patients were included in this study, with mean age of 55.21±10.00. Most of the patients were male (70%). The most common risk factor was hyperlipidemia (47%). Most of the lesions undergone angioplasty was in B2/C ACC/AHA class, and LAD was the most common vessel. In this study the rate of technical and procedural success was 100%. There was not any early or late thrombosis, and death, myocardial infarction and stroke (major adverse cardiovascular events, MACE) was similar to other drug eluting stents. Stenting with paclitaxel eluting stents is safe. Regarding its biocompatible polymer it doesn''t have any added hazard compared to bare metal stents. Further studies needed for other aspects