جستجوی مقالات مرتبط با کلیدواژه « saline » در نشریات گروه « پزشکی »

With the advent of parenteral, intravenous infusion for various purposes like chemotherapy, parenteral nutrition, radiocontrast intravenous injection for imaging studies, extravasation injuries are emerging as a serious problem with often disastrous complications, if not recognized early. Fortunately, if treated early, the affected extremities can be salvaged and hence the role of plastic surgeons cannot be over-emphasized, especially when it comes to the reconstruction of necrotic and ischemic wounds as a result of these injuries. Proper monitoring and immediate intervention will go a long way in minimizing the morbidity associated with these injuries. However, if there is a delay in recognition and treatment, it can lead to complications like skin necrosis, gangrene, extensive soft tissue defects and contractures. Treatment in these circumstances needs an individualized approach and entails wound debridement followed by skin grafts and flap cover. Documentation and prompt intervention can avoid medicolegal issues for the physician and the hospital.

The enhancement of osteogenesis by tissue engineering is a challenge in periodontal therapy. Several graft materials in conjunction with carriers, such as blood or saline, are used for this purpose. This study aimed to assess the effect of phosphate buffered saline (PBS), Hank's balanced salt solution (HBSS) and saline on the activity of MG-63 osteoblast-like cells in the presence and absence of beta-tricalcium phosphate (β-TCP).

In this in vitro experimental study, MG-63 osteoblast-like cells were cultured in 10% PBS, HBSS and saline (10%) with and without β-TCP granules for 24 and 72 h and five days. At 24 and 72 h, cell viability and proliferation were assessed. Alkaline phosphatase (ALP) activity test was used to assess bone activity. The data were analyzed using SPSS version 20 (IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp) via one-way and two-way ANOVA (P<0.05).

Pairwise comparisons showed no significant difference in the viability of MG-63 cells at 24 h in the three solutions (with equal β-TCP content) or with the negative control group (complete culture). At 72 h, significant differences were only observed in the reduction of cell proliferation between 10% saline without β-TCP and 10% saline with β-TCP , and also between HBSS without β-TCP and HBSS with β-TCP (P<0.05).

The three solutions did not induce ALP activity at 24 or 72 h and did not cause the formation of any calcified nodule at three or five days in MG-63 cells.

Intussusception is a major cause of acute abdomen in childhood. Prompt diagnosis and appropriate treatment of intussusception is of prime importance for preventing morbidity and mortality. In this study, we aimed to investigate the effectivity of ultrasound (USG)-guided hydrostatic reduction of intussusception with saline and to investigate the factors affecting the success of this method.
A total of 100 children with intussusception who were treated by hydrostatic reduction with saline were retrospectively reviewed. The effect of age, gender, duration of symptoms, rectal bleeding, number of reduction attempts performed, and the diameter and length of the invaginated segment measured on USG were evaluated.
Successful reduction was achieved in 88 (88%) patients. Mean age was 24.83 months, with 25.59 months in patients with successful reduction and 20 months in patients with failed reduction. Reduction was successful in 83.9% of the patients with a history of rectal bleeding and in 94.7% of the patients with no history of rectal bleeding (P > 0.05). Mean duration of symptoms was 2.74 days in the patients with successful reduction and 4.33 days in the patients with failed reduction. The mean diameter and length of the invaginated segments measured on USG were 3.5 cm and 5.12 cm in the patients with successful reduction and 4.27 cm and 9.23 cm in the patients with failed reduction, respectively. No significant difference was observed between the patients with successful and failed reduction in terms of rectal bleeding, vomiting, gender, age, and body weight (P > 0.05). It was also found that success rate increased as the number of reduction attempts increased and the success rate decreased as the duration of symptoms and the diameter and the length of the invaginated segment increased (P In conclusion, USG-guided reduction of intussusception with saline is a practical and safe method that yields high success rates. Repeating this method in patients with partial reduction that are clinically stable leads to a significant increase in the success of the procedure. A prolonged duration of symptoms and an increase in the size and the diameter of the invaginated segment may have adverse effects on the success of the procedure.

BackgroundBronchiolitis is the commonest cause of lower respiratory tract infection in infant. Respiratory syncytial virus is the commonest cause of bronchiolitis. This study aimed to assess the efficacy of nebulized 3% hypertonic saline and salbutamol in the treatment of acute bronchiolitis in comparison with nebulized 0.9% saline and salbutamol.
Materials and MethodsA prospective case second multicenter study was done at two pediatric tertiary centers at the period from 1st of December 2014 to 31 of March 2015. A total of 100 previously well infant and children of age 1-24 months with clinical diagnoses of bronchiolitis who were admitted to the hospital were included. They were divided into two groups, the study group received 4 ml of nebulized hypertonic 3% saline (for 14 days), and second group received 4 ml of nebulized normal 0.9% saline (for 14 days), each co-administer with 0.5 ml salbutamol.
ResultsAll patients with acute bronchiolitis having similar baseline characteristic, mean age 4.9 Standard deviation (SD) months, male gender constitutes 68% of the patients and the majority (67%) of the cases were below 6 months. The mean of clinical severity score at admission was 6.4 for normal saline (NS) group and 6.6 for hypertonic 3% saline (HS) group. The mean length of hospital stay of normal saline group = 4.3 Standard deviation (SD) day and for hypertonic saline group was = 4.7 Standard deviation (SD) day.
ConclusionWe didn’t find any advantage of hypertonic 3% saline over 0.9% normal saline in terms of length of hospital stay and clinical severity score.

During the detorsion of a torsioned ovary, oxidant agents are released andmelatonin as an antioxidant can reduce ischemia. We studied the histopathologicalchanges after using melatonin on experimental torsioned ovary in cat.

The aim of this experimental study was to investigate the effects ofMelatonin on histopathological changes in torsion – detorsion injury in cat ovary.

An adnexal torsion – detorsion model was created by using 20adult cats randomly divided equally in to 2 groups of Saline and Melatonin. Ischemia wasinduced by iathrogenic 360° clockwise torsion of the cat adnex for 3 hr. Reperfusionwas achieved for 3 hr. Melatonin or saline were injected intra peritoneally (10mg/kg) 30min before ovarian detorsion in both groups. After 3 hr of ovarian detorsion, ovariantissue was removed and fixed in 10% formalin solution, embedded in paraffin andevaluated for ischemic indices.

Histological examination showed a significant improvement in ovarianmorphology in the melatonin treated cats. Edema and vasoconstriction in saline groupwere more severe than Melatonin group (p-value = 0.009). Hemorrhage and leukocyteinfiltration were also more obvious in saline group (p-value 0.0018)

Our results demonstrated that Melatonin administration reduced ovarianhistopathological damage due to oxidative injury associated with torsion.