جستجوی مقالات مرتبط با کلیدواژه "salivary ph" در نشریات گروه "پزشکی"

Enhancing dental health and oral hygiene is essential for preventing dental caries. Recently, there has been significant interest in using natural ingredients in oral care products. This study aimed to compare the effects of herbal toothpaste containing Saqqez oleo-gum resin essential oil with Sensodyne toothpaste on the colony count of Streptococcus Mutans (S. mutans) and salivary pH levels.

A randomized double-blinded clinical trial with a crossover design was conducted with 40 students aged 18-35 years who were caries-free. Initially, unstimulated saliva samples were collected to determine the baseline mutans streptococci count and salivary pH levels. In the first phase, participants were randomly divided into two groups: Group I received herbal toothpaste containing Saqqez oleo-gum resin essential oil, while Group II used Sensodyne toothpaste. After supervised tooth brushing, saliva samples were collected again to assess pH levels and S. mutans counts. Following a 72-hour washout period, the procedures were repeated with the groups switching toothpastes according to the crossover design. Data were analyzed using the Mann-Whitney U test and Wilcoxon matched pairs signed-rank test, at a significance level of p<0.05.

A significant reduction in the S. mutans colony count and a significant increase in salivary pH levels were observed in both groups compared to their baseline values (P<0.05). However, no significant difference was found between the efficacy of the two toothpastes (P>0.05).

The effect of herbal toothpaste containing Saqqez essential oil on salivary pH and S. mutans level was comparable to that of commercial toothpaste evaluated in this study.

This study was performed to evaluate the effects of probiotics on salivary flow rate and pH in children with Acute Lymphocytic Leukemia (ALL) during chemotherapy.  

A randomized clinical trial was conducted on 11 children with ALL on induction and consolidation phases of chemotherapy. At the beginning, clinical examination of the oral mucosa and dental hygiene and interview regarding the presence of dry mouth were performed. Saliva samples were collected in the morning between 09.00-12.00 a.m., before and after 7 and 14 days gargling with probiotics. Each participant was instructed to gargle probiotics for 60 seconds, morning and night, for 14 days. Descriptive analysis was performed to compare salivary flow rate and salivary pH before and after 7 to 14 days gargling, using Paired t-test because the data is normally distributed (P<0.05).

7 (63.6%) out of 11 patients complained of a dry mouth sensation. Before gargling probiotics, salivary flow rate and salivary pH were 0.52 and 6.8, respectively. After 14 days of gargling with probiotics, there was a significant increase in salivary flow rate to 0.64 (P<0.05), while salivary pH changed unsignificantly to 6.99 (P>0.05).

Gargling with probiotics in children with ALL during induction and consolidation chemotherapy phase, after 14 days showed a significant increase in salivary flow rate but unsignificant change in salivary pH.

 Systemic corticosteroid use is undeniable for many patients, and many require long-term use of such drugs. Corticosteroids have adverse and irreversible effects on all organs of the body. One of these complications that have not been studied fully is the drug effect on salivary gland function and the quantity and quality of saliva. Some of the many properties of saliva affected by these drugs are saliva pH and viscosity changes and, therefore, its effect on oral health.

 This study was performed on 90 cumulative saliva samples containing three groups of corticosteroid users, including more than 15 mg/day, corticosteroid users less than 15 mg/day, and healthy and non-drug users. Each group contained 30 samples. The unstimulated cumulative saliva of volunteers was collected by spitting method for 5 minutes, and the pH of the samples were measured by digital pH meter, and the viscosity of the samples was calculated based on the comparison of the amount of movement of saliva in the capillary tube in millimeter per second with the control fluids. Statistical analysis was performed by Statistical Package for Social Sciences (SPSS V. 18) software and the analysis of variances (ANOVA), Tukey’s multiple comparisons, or their nonparametric equivalents tests were used.

 The viscosity of saliva in patients with corticosteroid > 15 mg/day was higher than the healthy subjects (P = 0.028). Also, salivary pH in patients taking corticosteroid < 15mg/day was lower than healthy ones (P = 0.017). There was no significant relationship between gender with pH and salivary viscosity (P = 0.933).

 Long-term consumption of corticosteroids reduces the pH of saliva and increases its viscosity. Therefore Corticosteroids can cause quantitative and qualitative changes in saliva. It also can affect oral and dental health. Hence, the oral health of people taking corticosteroids should be more noticed.