جستجوی مقالات مرتبط با کلیدواژه "sensory block" در نشریات گروه "پزشکی"
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سابقه و هدف
محل تزریق در بیحسی نخاعی ازجمله عواملی است که بر ارتفاع بلوک حسی تاثیرگذار است. هدف این کارآزمایی بالینی، مقایسه تاثیر انجام بیحسی نخاعی در سطح L3-L4 و L4-L5 بر سطح بلوک حسی-حرکتی و وضعیت همودینامیک در جراحی سزارین است.
مواد و روشها:
70 نفر از بیماران کاندید سزارین الکتیو تحت بیحسی نخاعی (10 میلیگرم بوپیواکایین 0/5 درصد به همراه 2/5 میکروگرم سوفنتانیل) بهطور تصادفی در دو گروه 35 نفره بیحسی نخاعی در سطح L3-L4 (گروه اول) و L4-L5 (گروه دوم) قرار گرفتند. اطلاعات دموگرافیک، سطح بلوک حسی، درجه بلوک حرکتی، زمان شروع بیحسی، زمان بازگشت سطح حسی به T10، وضعیت همودینامیک، عوارض بیحسی نخاعی وآپگار نوزاد در دو گروه بررسی شد.
یافتهها:
دو گروه از نظر میانگین سنی تفاوت معنیداری نداشتند. 22/9 درصد از بیماران گروه اول و 40 درصد از بیماران گروه دوم سطح بیحسی در سطح مهره هشتم توراسیک داشتند (T8). همچنین در22/9 درصد از بیماران گروه اول سطح بیحسی زیاد در سطح مهره چهارم توراسیک (T4) مشاهده شد، درحالیکه در هیچیک از بیماران گروه دوم بلوک حسی در سطح T4 رویت نشد (0/008 =P). فراوانی هیپوتانسیون (82/9 درصد در برابر 8/6 درصد)، برادیکاردی (34/3 درصد در برابر 8/6 درصد) و تهوع و استفراغ حین عمل (65/7 درصد در برابر 11/4 درصد) در گروه اول بیشتر از گروه دوم بود (0/001<p).
نتیجهگیری:
انجام بیحسی نخاعی در فضای L4-L5 کمری در مقایسه با فضای L3-L4 علاوه بر ایجاد سطح بیحسی کافی با عوارض کمتری ازجمله هیپوتانسیون، برادیکاردی و تهوع و استفراغ در جراحی سزارین همراه است.
کلید واژگان: بلوک حسی, بی حسی نخاعی, تغییرات همودینامیک, سزارینBackground and ObjectiveThe injection site in spinal anesthesia is one of the factors that can affect the height of the sensory block. This clinical trial study aimed to compare the effect of spinal anesthesia at L3-L4 and L4-L5 on the level of sensory-motor block and hemodynamic status in cesarean section.
Materials and MethodsSeventy patients undergoing elective cesarean section and receiving spinal anesthesia (10 mg of 0.5% bupivacaine plus 2.5 μg of sufentanil) were randomly divided into two groups of 35 with spinal anesthesia at L3-L4 (group 1) or L4-L5 (group 2). The two groups were compared concerning demographic data, hemodynamic status, level of sensory block, degree of motor block, time to return the sensory level to T10, complications of spinal anesthesia, and neonate Apgar score.
ResultsThere was no significant difference between the two groups in the mean age (P=0.329). In the first group, 22.9%, and in the second group, 40% of the patients had the level of anesthesia at the eighth thoracic vertebra (T8). None of the patients had zero or one score in both groups. Hypotension (82.9% vs. 8.6%), bradycardia (34.3% vs. 8.6%), and intraoperative nausea and vomiting (65.7% vs. 11.4%) were higher in the first group than in the second group (P<0.001).
ConclusionPerforming spinal anesthesia in L4-L5 lumbar space, compared to L3-L4 space, in addition to creating a sufficient level of anesthesia, is associated with fewer complications, such as hypotension, bradycardia, as well as nausea and vomiting, in cesarean section.
Keywords: Anesthesia Spinal, Cesarean Section, Hemodynamic Changes, Sensory Block -
Background
When performing spinal anesthesia for cesarean section, it is important to determine the appropriate anesthetic dose as well as to predict the level of spinal anesthesia. In this study, it was hypothesized that some anthropometric measurements may be related to maximum sensory block and hemodynamic changes.
ObjectivesThe aim of this study are to find maternal anthropometric values that are correlate with the level of spinal anesthesia.
MethodsMaternal anthropometric measurements, including height, weight, supine and standing abdominal circumference (AC), and hip circumference, were recorded before spinal anesthesia for cesarean section. Spinal anesthesia was induced by administering 8 mg of 0.5% hyperbaric bupivacaine and 20 μg of fentanyl at the L3-L4 interspace. The level of sensory block was determined using pin-prick at 1, 5, 10, and 15 minutes after spinal anesthesia. The sensory block level and hemodynamic adverse events were analyzed in relationship to anthropometric measurements.
ResultsThe supine AC/height ratios significantly correlate with the maximal sensory block level at 5, 10, and 15 minutes after the injection of spinal anesthetic (P = 0.001, P < 0.001 and P < 0.001, respectively). Further, there were significant correlations between body mass index (BMI) and sensory block level at every assessment (P = 0.041, P = 0.002, P = 0.001 and P < 0.001, respectively). When comparing the groups with and without hypotension, BMI, weight, and supine AC/height ratio were found to be significantly higher in the group with hypotension (P = 0.002, P = 0.004 and P = 0.006, respectively).
ConclusionsWe conclude that BMI and AC/height ratio correlate with the sensory block level of spinal anesthesia for cesarean section.
Keywords: Spinal Anesthesia, Sensory Block, Hypotension, Hemodynamics, Fentanyl, Cesarean Section, Bupivacaine, Anthropometric Measurements, Anesthetics -
Background
Spinal anesthesia is the method of choice for the cesarean section. Hypotension is a common complication of this method.
ObjectivesThis study aimed to compare the effect of spinal anesthesia in the sitting and lateral positions on the onset time of sensory block and hemodynamic condition in cesarean sections.
MethodsIn this clinical trial, 106 elective cesarean section candidates under spinal anesthesia were selected and randomly divided into two groups: spinal anesthesia in the sitting position (group S) and the lateral position (group L). The onset time of the sensory block, quality of sensory and motor block, hemodynamic condition, frequency of hypotension, nausea, and vomiting, and the doses of ephedrine and atropine were compared between both groups. Data were analyzed with SPSS version 16 software at a 95% confidence level.
ResultsThere was no statistically significant difference between the two groups in terms of age. The frequency of hypotension in L and S groups was 24.5% and 57.7%, respectively (P = 0.001), in minute 6 after spinal anesthesia and 5.7% and 36.5%, respectively (P < 0.001), in minute 8 after spinal anesthesia. The mean time to reach the sensory level of T6 was 1.30 ± 0.43 min versus 4.54 ± 2.12 min (P < 0.001), motor block score in minute 5 was 2.98 ± 0.14 versus 2.82 (P = 0.044), and ephedrine dose was 11.5 mg and 16.92 mg in the L and S groups, respectively (P = 0.010). The maximum sensory-motor block and satisfaction of women with spinal anesthesia were significantly higher in the lateral position than in the sitting position (P < 0.05).
ConclusionsCesarean sections under spinal anesthesia in the lateral position than in the sitting position lead to a more rapid sensory and motor block, reduced ephedrine consumption, and enhanced satisfaction of women.
Keywords: Cesarean Section, Spinal Anesthesia, Hemodynamic Changes, Sensory Block, Lateral Position, Sitting Position -
Background
Spinal anesthesia is the most common technique used for cesarean delivery due to some advantages compared to regional anesthesia. It is easily performed and provides a rapid onset of block. Though bupivacaine is a generally used long-acting amide type local anesthetic drug for spinal anesthesia, ropivacaine may sometimes be selected.
ObjectivesThis prospective, randomized, double-blinded study was aimed at comparing clinical efficacy and safety between ropivacaine and bupivacaine during cesarean section.
MethodsAfter getting ethical committee approval and written informed consent, 65 women who referred to Imam Khomeini Hospital of Ahvaz, Iran in 2018 were chosen for elective cesarean delivery under spinal anesthesia. They were randomly allocated to receive either ropivacaine 1% (n = 33) or bupivacaine 0.5% (n = 32). Afterwards, the differences in the anesthetic efficacy, vital signs,
and hemodynamics of participants between the two groups were recorded.ResultsDuration of sensory block was shorter in the ropivacaine group than bupivacaine group (132.521.6 min vs. 175.826.2 min; P < 0.001). Ropivacaine also produced a shorter duration of motor blockade than bupivacaine (124.820.2 min vs. 168.221.7 min; P < 0.001). There is no difference between the two groups in terms of systolic and diastolic blood pressure, but the heart rate
of patients in the bupivacaine group is significantly higher than the ropivacaine group.ConclusionsThe results suggest that ropivacaine and bupivacaine are two efficient drugs in anesthesia in the cesarean section, ropivacaine is a better choice due to little influence on the hemodynamics and shorter duration of sensory block and motor block which are useful for the recovery and also safe to the patients.
Keywords: Bupivacaine, Caesarean Section, Motor Block, Ropivacaine, Sensory Block, Spinal Anesthesia -
ObjectiveTo compare the efficacy of parasagittal interlaminar (PIL) and midline interlaminar (MIL) approaches for epidural block in patients with lower limb orthopedic surgery.MethodsThis double-blind randomized clinical trial was performed on 40 patients undergoing tibial shaft fracture surgery. In PIL group, an 18-gauge, 3.5 inch, Tuohy needle was placed at the level of L2-3 or L3-4 intervertebral spaces and pushed forward in a posteroanterior (PA) direction vertical to the body surface. After determining the most lateral place for needle arrival in an anteroposterior (AP) view, needle was pushed forward into the epidural space. For the MIL group, needle was pushed forward from the midline interspinous space with the same method. After confirmation of needle position, 1 mL of contrast was injected to confirm the epidural space distribution and then 15 ml lidocaine 2% was injected. The sensory and motor block level, onset, duration, heart rate (HR), mean arterial pressure (MAP), and arterial oxygen saturation (SPO2), and success rate were recorded.ResultsMean patients’ baseline characteristics showed no statistically significant difference between the two groups. (p>0.05). Outcome measures were statistically different and significantly higher in PIL group (p-values for sensory block level <0.001, motor block level <0.001, duration of sensory block: <0.001 and duration of motor block <0.001 and success rate: <0.001). Hemodynamic variables didn’t show statistically significant difference between the two groups (p-values for Systolic pressure: 0.997, diastolic pressure:0.579, MAP:0.585, HR:0.710).ConclusionEpidural anesthesia with parasagittal interlaminar approach provide deep motor block, high sensory level block, and hemodynamic stability.Keywords: Anesthesia, Epidural, Interlaminar approach, Parasagittal approach motor block, Sensory block, Hemodynamics stability, Success rate
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BackgroundDecreasing side effects and improving the quality of block in caesarean sections by appropriate dosage of local anesthetics and adjuvants could play an important role in the safe management of cesarean section. The present study aimed at comparing the effects of 3 different doses of intrathecal hyperbaric bupivacaine injected with a fixed dose of sufentanil in cesarean sections.MethodsIn a double- blind randomized clinical trial, 105 candidates of elective cesarean section were randomly assigned into 3 groups of 8, 9, and 10 mg of intrathecal bupivacaine plus sufentanil 2.5 µg. The maximum level of sensory block, the intensity of motor block, and vital signs were measured at regular intervals. The incidence of hypotension and bradycardia were also recorded.ResultsNo significant difference was found between the maximum level of sensory block and the intensity of motor block in 3 groups. The incidences of hypotension and bradycardia as well as administration of atropine and ephedrine were comparable among the 3 groups (P > 0.05).ConclusionsAccording to similar effects of different doses of bupivacaine, administration of lower doses of bupivacaine (8mg) is more reasonable for spinal anesthesia for cesarean section.Keywords: Cesarean Section, Bupivacaine, Sensory Block, Motor Block, Anesthesia
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IntroductionDexmedetomidine, which is an alpha 2 agonist, reduces the transmission of pain signals and has an independent inhibitory effect on nerve action potential. The purpose of this study was to examine the effects of adding dexmedetomidine to lidocaine in an axillary block.MethodsIn this randomized, double-blind study 40 patients included patients were divided randomly into two groups of 20: In the first group, 39 cc of 1% lidocaine plus 1cc of normal saline was administered and the 2nd group received dexmedetomidine 1cc (100µg) in addition to 39 cc of 1% lidocaine. The onset and persistence of the sensorimotor block and hemodynamic changes including heart rate and systolic and diastolic blood pressure before, during, and after surgery were compared.ResultsAge, sex, type of surgery, duration of surgery, and other demographic characteristics were not significantly different in two groups (P>0.05). Onset of the sensory and motor block was similar in both groups, but the persistence of the sensory and motor block and analgesia in the treatment group was significantly higher (PConclusionThe results of this study showed that adding dexmedetomidine to lidocaine in an axillary block did not alter the onset of the sensory and motor block, but the sensory and motor block duration and analgesia was increased. Despite significant differences in hemodynamic responses between the two groups, these changes were not clinically significant in ASA1 patients.Keywords: Lidocaine, dexmedetomidine, axillary block, sensory block, motor block, hemodynamic
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BackgroundThe goals of this study are evaluation the effect of intravenous (IV) granisetron on the duration of sensory and motor block produced by intrathecal hyperbaric bupivacaine and also post-operative nausea and vomiting in patients undergoing outpatient cystoscopy.Methods62 patients, undergoing cystoscopy received either 3 mg IV granisetron or placebo 15 minutes before the spinal block. Sensory and motor block were assessed after the intrathecal injection of bupivacaine every 2 minutes until the maximum block was achieved and thereafter every 15 minutes until recovery from the sensory and motor block.ResultsDemographic data were not statistically different in the study groups. Duration of sensory and motor block were also not statistically different between the study groups (P = 0.060 and P = 0.070 respectively). No patient in either group had vomiting. Seven patients in saline and zero patient in granisetron group had nausea that was statistically significant (P = 0.040). Time to discharge after surgery was 243 ± 21 and 239 ± 24 minutes in granisetron and control group respectively (P = 0.150).ConclusionsSystemic granisetron had no effect on the duration of sensory and motor block produced by spinal anesthesia with hyperbaric bupivacaine.Keywords: Bupivacaine, Granisetron, Sensory block, Motor block, Anesthesia, Spinal, Outpatients, Cystoscopy
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سابقه و هدفانجام جراحی سزارین تحت بیحسی نخاعی به سطح بیحسی بالایی(T4-T6) نیازمند است که رسیدن به آن به عوامل مختلفی (دز و باریسیته دارو، پوزیشن، سرعت تزریق و...) بستگی دارد. هدف از این مطالعه ارزیابی تاثیر سرعت تزریق نخاعی بوپیواکائین 5/0% بر سطح بلوک حسی و حرکتی در بیماران کاندید جراحی سزارین می باشد.مواد و روش هااین مطالعه کارآزمایی بالینی دوسوکور پس از تاییدیه کمیته اخلاق بر روی 75 خانم باردار ترم کاندید سزارین انجام شد.همه بیماران تحت بیحسی نخاعی قرار گرفته و بطور تصادفی بر اساس سرعت تزریق ماده بیحسی در فضای ساب آراکنوئید (که شامل 10میلی گرم بوپیواکائین 5/0% به همراه 5/2 میکروگرم سوفنتانیل و 5/0 میلی لیتر سالین نرمال با حجم کلی 3 میلی لیتر) در سه گروه 25 نفری قرار گرفتند. گروه تزریق سریع (F)، ماده بیحس کننده را با سرعت 1میلی لیتر در ثانیه یعنی حجم 3 میلی لیتری بوپیواکایین را در عرض 3 ثانیه، گروه تزریق متوسط (M) حجم 3 میلی لیتری را با سرعتml/s 2/0 یعنی در عرض 15 ثانیه و گروه تزریق آهسته (S) حجم 3 میلی لیتری را با سرعتml/s 04/0 یعنی در عرض 75 ثانیه دریافت نمودند. سپس بلافاصله سطح بلوک حسی و حرکتی و زمان رسیدن به آن، هریک دقیقه بترتیب با استفاده از روش pinprick و اسکور بروماژ تعیین گردید. فشارخون و ضربان قلب در فواصل منظم اندازه گیری و بهمراه میزان بروز تهوع و استفراغ و مقدار افدرین مصرفی ثبت شد (2N 2012122210841: IRCT).یافته هااین مطالعه نشان داد که میانه سطح بلوک حسی در گروه های آهسته (S)، متوسط(M) و سریع (F) بترتیبT6، T5 وT4 بود که در گروه سریع به طور معنی داری بالاتر از دو گروه دیگر بود. میانگین زمان شروع بی حسی در گروه سریع، 4/0±3 ودر دو گروه S وM بترتیب 7/0±4/4 و 4/0±2/4 دقیقه بود (001/0P<). میزان بروز هیپوتانسیون و میانگین زمان رسیدن به سطح حسی T10نیز در گروه سریع در مقایسه با دو گروه دیگر بالاتر بود (گروه سریع 4/14±8/114، متوسط 7±6/81 و آهسته 3/18±74 دقیقه (001/0P<). در گروه سریع شیوع تهوع و استفراغ 76% و 48% بود در حالیکه این میزان در گروه آهسته بترتیب 20% و 8% و در گروه متوسط 16% و 8% بود (001/0p<).نتیجه گیریتزریق سریع بوپیواکایین نخاعی سبب گسترش بیشتر سطح بلوک حسی - حرکتی و افزایش هیپوتانسیون و تهوع- استفراغ در جراحی سزارین می گردد.
کلید واژگان: بوپیواکایین, بی حسی نخاعی, سزارین, بلوک حسی, هیپوتانسیونBackground And ObjectiveAdequate sensory block for cesarean section under spinal anesthesia is T4-T6 that several factors (local anesthetic dose and baricity, position, rate of injection …) correlate with block height. This study was designed to evaluate the efficacy of intrathecal injection rate of bupivacaine 0.5% on sensory and motor block in cesarean section.MethodsAfter confirmation of Ethic committee in this double blind clinical trial study, 75 term parturients were evaluated. All of patients underwent spinal anesthesia and allocated randomly to 3 groups (n=25) according to intrathecal injection rate of 10 mg bupivacaine 0.5% and 2.5 μg sufentanil and 0.5 ml normal saline in total volume of 3 ml. Patients received intrathecal local anesthetic by injection rate of 1ml/sec or 3ml/3 sec in Fast group, 0.2 ml/sec or 3ml/15 sec in Moderate group and 0.04 ml/sec or 3ml/75 sec in Slow group. Immediately sensory and motor block level were determined every 1 minute by Pinprick and Bromage score respectively. Blood pressure and heart rate was measured regularly, and nausea, vomiting and ephedrine dose was recorded. (IRCT=IRCT2012122210841N2)FindingsOur study demonstrated that sensory level in Fast, Moderate and Slow groups was respectively T4, T5 and T6 that significantly was higher in Fast group. Timing of sensory block in Fast group was 3±0.4 and in Moderate and Slow groups were 4.4±0.7 and 4.2±0.4 minutes respectively (p<0.001). Fast injection of spinal anesthetic significantly increases prevalence of hypotension and reducing time of sensory level to T10 in cesarean delivery (F=114.8±14.4, M=81.6±7 and S=74±18.3 minutes, p<0.001). Incidence of nausea and vomiting in Fast group was 76% and 48% whereas in Moderate was 16% and 8% and in Slow group was 20% and 8% (p<0.001).ConclusionWe concluded that fast intrathecal injection of bupivacaine increases sensory and motor block and hypotension, nausea and vomiting in cesarean section.Keywords: Anesthesia, Spinal, Bupivacaine, Cesarean section, Hypotension, Sensory block -
BackgroundRegional anesthesia is widely used to perform different surgical procedures including those performed on the extremities. In this study، the anesthetic effects of adding intrathecal neostigmine or magnesium sulphate to bupivacaine in patients under lower extremities surgeries were assessed.Materials And MethodsIn this double-blind randomized clinical trial، 90 patients، candidate for lower extremities surgeries in a training hospital، were recruited. The patients with ASA class I and II aging from 20 to 65 years between 2009 and 2010 were evaluated. The selected patients were randomly assigned to receive either bupivacaine alone (Group A، n=30)، or bupivacaine plus magnesium sulphate 50% (Group B، n=30)، or bupivacaine plus neostigmine (Group C، n=30). Then sensory and motor onset and complete block and the time of recovery were measured.ResultsThe sensory block onset time were 3. 03±0. 981 in group A، 3. 90±2. 71 in group B and 3. 7±1. 08 in group C and knee flexion time were not significantly different among the three groups (P > 0. 05)، whereas the time to complete motor block was significantly longer in group C and motor recovery time were significantly different between groups (P=0. 001).ConclusionsAccording to the obtained results، it may be concluded that magnesium sulphate is a safe and effective adjuvant for increasing the onset time of motor block.Keywords: Bupivacaine, magnesium sulphate, motor block, neostigmine, sensory block, Spinal anesthesia
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زمینه و هدفبیحسی موضعی داخل وریدی یک روش بیحسی مفید در اعمال جراحی کوتاه مدت و سرپایی اندام فوقانی است. این روش با مشکلاتی مانند درد محل تورنیکه و از بین رفتن سریع بیدردی همراه است. هدف از انجام این مطالعه مقایسه تاثیر افزودن پاراستامول و سولفات منیزیوم به لیدوکائین در بیحسی موضعی داخل وریدی بود.روش بررسیدر این کارآزمایی بالینی 90 بیمار به طور تصادفی به سه گروه پاراستامول (P)، سولفات منیزیوم (Mg) و شاهد (C) تقسیم شدند. متغیرهای مورد بررسی عبارت بودند از میزان درد، فاصله تزریق تا بلوک حسی و حرکتی، مدت زمان بلوک حسی و حرکتی و تغییرات گازهای خون وریدی. در نهایت اطلاعات به دست آمده از سه گروه مورد نظر با یکدیگر مقایسه شدند.یافته هافاصله تزریق تا بلوک حسی و حرکتی در گروه Mg نسبت به دو گروه دیگر به طور معنی داری کاهش یافت (05/0>p). مدت بلوک حرکتی در گروه Mg نسبت به گروه C به طور معنی داری بیشتر بود، اما بین دو گروه Mg و P اختلاف معنی داری وجود نداشت (05/0>p). اختلاف بین دو گروه P و C در هیچ یک از این موارد معنی دار نبود. یافته دیگر این بود که هیچ یک از دو دارو در کاهش درد بیماران تاثیر معنی داری نداشتند. در بررسی گازهای خونی وریدی مشاهده گردید که میزان تغیرات در گروه Mg به طور معنی داری از گروه P بیشتر بود (05/0>p).نتیجه گیریافزودن سولفات منیزیوم به لیدوکائین در بیحسی موضعی داخل وریدی باعث بهبود وضعیت بلوک حسی و حرکتی می شود و تاثیر قوی تری نسبت به پاراستامول دارد. از سوی دیگر پاراستامول در پیشگیری از ایسکمی بافت ها در بیحسی موضعی داخل وریدی بسیار موثر است و از بروز تغییر در گازهای خونی وریدی جلوگیری می نماید. هیچ یک از این دو دارو در کاهش درد ناشی از تورنیکه موثر نیستند.
کلید واژگان: بیحسی موضعی داخل وریدی, لیدوکائین, پاراستامول, سولفات منیزیوم, بلوک حسی, بلوک حرکتی, گازهای خونی وریدیBackgroundIntravenous regional anesthesia (IVRA) is an efficient method for short-term procedures of the upper extremities. Some defects are associated with IVRA including tourniquet-related pain and insufficient duration of the anesthesia. The main purpose of the current study was to compare the effects of adding paracetamol or magnesium sulfate to lidocaine in IVRA on pain، venous blood gasses (VBG) and sensory and motor block.MethodsThere were 90 patients contributed in the current study. Patients were divided into paracetamol (P)، magnesium sulfate (Mg) and control (C) groups، randomly. Severity of the pain، time interval between the injection and onset of the sensory and motor block، duration of the sensory and motor block and the changes of VBG were measured.ResultsThe onset of the sensory and motor block was reduced significantly in Mg group (p<0. 05). There was a meaningful increase in the motor block duration in Mg group in relation to C group (p<0. 05)، but no statistically significant difference between Mg and P groups. Also، there was no meaningful difference between C and P groups in the means of onset of block and block duration. Neither MgSO4 nor paracetamol decreased the tourniquet-related pain. The changes of VBG were significantly lesser in the P group.ConclusionAdding MgSO4 to lidocaine improves the sensory and motor block in the IVRA. In other hand، paracetamol prevents ischemic changes to occur. None of these drugs are helpful to relief the tourniquet-related pain.Keywords: Intravenous regional anesthesia, lidocaine, paracetamol, magnesium sulfate, sensory block, motor block, venous blood gasses -
زمینه و هدفروش های مختلفی برای طولانی تر شدن بلوک شبکه آگزیلاری در اعمال جراحی اندام فوقانی معرفی شده است. در این مطالعه سعی شده است تاثیر دگزامتازون در ترکیب با لیدوکایین در بلوک شبکه آگزیلاری مورد بررسی قرار گیرد.روش بررسیمطالعه حاضر به صورت یک کارآزمایی بالینی تصادفی شده دو سوکور طراحی و اجرا شد. بیماران کاندید عمل جراحی اندام فوقانی که در اتاق عمل اورژانس بیمارستان حضرت فاطمه (س) بستری شده بودند، بر اساس معیارهای ورود و خروج وارد مطالعه شدند. بیماران به طور تصادفی به دو گروه30 نفره تقسیم شدند. در گروه اول در بیماران برای بلوک شبکه آگزیلاری از ترکیب 34 سی سی لیدوکایین 5/1% با 2 سی سی بیکربنات و 2سی سی آب مقطراستفاده شد (گروه کنترل یا لیدو کایین). محلول مورد استفاده برای بلوک در گروه دوم مشابه گروه اول بود با این تفاوت که 2 سی سی دگزامتازون (8 میلی گرم) به جای آب مقطر به آن افزوده شد (گروه دگزامتازون). شروع زمان بلوک حسی و حرکتی و سمپاتیک، مدت زمان بلوک کامل حسی و حرکتی و شدت درد پس از عمل در بیماران اندازه گیری و ثبت شد. داده های به دست آمده با استفاده از نرم افزار آماری SPSS V.13 مورد تجزیه و تحلیل قرار گرفت. داده های کمی به صورت میانگین و انحراف معیار و داده های کیفی به صورت فراوانی نمایش داده شده است. برای مقایسه داده های کیفی از آزمون کای دو و در متغیرهای کمی از آزمون t-test استفاده شد.یافته هازمان شروع بلوک حسی و حرکتی و سمپاتیک در دو گروه مشابه بوده و اختلاف معنی داری با یکدیگر نداشتند. مدت زمان بلوک و اولین زمان درخواست مسکن پس از عمل در گروه دگزامتازون به طور معنی داری بیش از گروه لیدوکایین و بیکربنات بود. شدت درد پس از عمل از زمان ریکاوری تا ساعت ششم به طور معنی داری در گروه دگزامتازون کمتر از گروه لیدوکایین بودنتیجه گیریمطالعه حاضر نشان داد که افزودن دگزامتازون به مخلوط بیکربنات و لیدوکایین برای بلوک شبکه آگزیلاری، طول مدت بلوک را افزایش می دهد. این افزایش در مورد بلوک حسی بیشتر از بلوک حرکتی بود. ضمنا طول مدت بی دردی پس از عمل در این گروه بیشتر از گروه مخلوط بیکربنات و لیدوکایین بود.
کلید واژگان: بلوک شبکه آگزیلاری, لیدوکایین, دگزامتازون, بلوک حسی, بلوک حرکتیBackground And AimMany different routes have been introduced for prolonging the duration of axillary block in upper extremity procedures. In this study the effect of adding dexamethasone to lidocaine during axillary plexus block has been studied. Patients andMethodsThis study was designed and performed as a double blind randomized clinical trial.The patients candidated for upper extremity procedures in Hazrat Fatemeh Hospital operation room, entered the study based on inclusive and exclusive criteria.The patients were divided in to two 30-person groups randomly. For axillary block in the first group (control or lidocaine group), a combination of 34cc lidocaine1.5 %, 2cc sodium bicarbonate and 2cc distilled water was used in the second group(dexamethasone group) the utilized solution was similar to that used in the first group but with 2cc of dexamethasone (8 mg) used instead of distilled water. The onset of sensory, motor and sympathetic block, duration of sensory and intensity of post operative pain was measured and recorded.The data was analysed with SPSS V.13.The quantitative data was displayed with mean and standard deviation. The qualitative data was displayed with frequency.The Chi square and t-tests were used for quality data quantity data, respectively.ResultsThe onset of sensory, motor and sympathetic block was similar in both groups and no significant statistical difference was present.The duration of the block and the time of the first request for analgesia post operatively were meaningfully longer in the dexamethasone group than lidocaine group(control group). Also the intensity of post operative pain from recovery to 6th hour after operation was meaningfully less in dexamethasone group than in control group.ConclusionThis study revealed that addition of dexamethasone to the combination of sodium bicarbonate and lidocaine for axillary plexus block can prolong the duration of block.Increase in the duration is more prominent for sensory than motor block. Meanwhile the post operative analgesia in this group was more than lidocaine group.Keywords: Axillary plexus block, Lidocaine, Dexamethasone, Sensory block, Motor block -
زمینه و هدفبی هوشی نخاعی به دلیل راحتی تکنیک و نیاز به میزان کم داروی بیحسی موضعی و عوارض نسبتا کمتر در مقایسه با بیهوشی عمومی در بین متخصصین بیهوشی از مقبولیت زیادی برخوردار است. لیدوکائین بطور وسیعی در این روش بکار می رود و مسلما افزایش طول مدت بی دردی آن در طی عمل جراحی می تواند بر مقبولیت این روش بیفزاید. امروزه اپی نفرین و فنتانیل به طور وسیعی جهت بهبود کیفیت بلوک و افزایش زمان بلوک بی هوشی نخاعی استفاده می شوند و از آنجا که مقایسه ای بین این دو دارو صورت نگرفته است، مطالعه حاضر با هدف بررسی مدت زمان بلوک حسی و حرکتی ناشی از تزریق این دو دارو با هم و به تنهایی به همراه لیدوکائین انجام گرفت.روش بررسیاین مطالعه به صورت کارآزمایی بالینی دو سویه کور انجام شده است. سه گروه 20 نفری از بیماران کاندید عمل جراحی قسمت تحتانی شکم به طور تصادفی انتخاب و تحت بی هوشی نخاعی به ترتیب با مخلوط 50 میلی گرم لیدوکائین+0.2 میلی گرم اپی نفرین ''(گروه اول)، 50 میلی گرم لیدوکائین+20 میکروگرم فنتانیل+0.2 میلی گرم اپی نفرین (گروه دوم) و 50 میلی گرم لیدوکائین+20 میکروگرم فنتانیل (گروه سوم) قرار گرفتند. سپس بیماران از نظر طول مدت بلوک حسی و حرکتی و تغییرات همودینامیک مورد بررسی قرار گرفته و با استفاده از آزمون های آماری کای دو و ANOVA مقایسه گردیدند.یافته هاتوزیع فراوانی از نظر جنس و میانگین سنی در هر سه گروه یکسان بود (p>0.05). میانگین طول مدت بلوک حسی در گروه اول 19.02±130.25 دقیقه، در گروه دوم 32.7±133 دقیقه و در گروه سوم 14.58±116 دقیقه بود که تفاوت معنی دار آماری بین سه گروه وجود نداشت. میانگین طول مدت بلوک حرکتی در گروه اول 14.63±120.95 دقیقه و در گروه دوم 25.74±118.75 دقیقه و در گروه سوم 18.23±107 دقیقه بود که تفاوت معنی دار آماری بین سه گروه وجود نداشت و همچنین تغییرات همودینامیک در هر سه گروه اختلاف معنی داری با هم نداشتند.نتیجه گیرینتایج این مطالعه نشان داد که افزودن ترکیب دارویی 20 میکروگرم فنتانیل و 0.2 میلی گرم اپی نفرین به داروی بی حسی موضعی لیدوکائین طول مدت بلوک حسی و حرکتی و تغییرات همودینامیک را نسبت به هر یک از دو داروی فوق به تنهایی تغییر نمی دهد و در نتیجه نیازی به استفاده هم زمان از دو دارو نیست. لذا مطالعات تکمیلی با دوزهای متفاوتی از داروهای فوق پیشنهاد می گردد.
کلید واژگان: اپی نفرین, بلوک حرکتی, بلوک حسی, بیهوشی نخاعیBackground And AimSpinal anesthesia due to its simplicity, rapid onset of its effect and low dose of drug administration, is a desirable procedure to anesthetics particularly for lower extremity and lower abdomen operations. Lidocaine is widely used in this method of anesthesia for prolongation of the sensory block. In the method, different drugs are used to prolong the duration of sensory block. Fentanyl and epinephrine are being used widely for this purpose and so far, the effects of these drugs were not compared. Therefore, in this study, the effect of the two drugs, alone or together, with and without lidocaine, on the duration and intensity of sensory and motor block has been investigated.MethodsIn this double-blinded clinical trial, 60 candidates for elective surgery of lower abdomen were randomly divided into three equal groups. For spinal anesthesia, the first group was subjected to 50 mg lidocaine plus 0.2 mg epinephrine, the second one to 50 mg lidocaine plus 0.2 mg epinephrine and 20-µg fentanyl and the third group to 50 mg lidocaine plus 20-µg fentanyl. Subsequently, the patients in the 3 groups were evaluated and compared for the duration of sensory and motor block and their hemodynamic variations. The data was analyzed using ANOVA and Chi-square tests.ResultsAge and sex distribution among the three groups was not significantly different. The mean of sensory block duration in the first, second and third groups were 130.25±19.05, 133±32.7 and 116±14.58 min, respectively with no significant difference. The mean of motor block duration in the first, second and third groups were 120.95±14.63, 118.75±25.74 and 107±18.23 min, respectively. ANOVA test showed no significant difference among the three groups as well. Also, with respect to hemodynamic variation, there was no significant difference among the three groups.ConclusionOur findings showed that addition of epinephrine and fentanyl and combination of them to the lidocaine had no effect on the duration of sensory and motor block and hemodynamic variations. Therefore, combined use of these drugs is not necessaryKeywords: Epinephrine, Motor block, Spinal anesthesia, Sensory block
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