جستجوی مقالات مرتبط با کلیدواژه "serum chemistry" در نشریات گروه "پزشکی"
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The present work focuses on the synthesis and biological evaluation of metal complexes of mixed acetylsalicylic acid and para-aminobenzoic acid in ratio 1:1:1 to give a complex type: [M(ASA)(PABA)(H2O)n(Cl2)x](Cl2)y (where M = Cu(II), Cd(II), Ni(II), Fe(III), or Mn(II); ASA = Acetylsalicylic acid; PABA = para-aminobenzoic acid; n = 0 or 2; x = 0 or 1; y = 0 or 1). The metal complexes were obtained by a refluxing method and characterized by elemental analysis, melting point, conductivity measurements, ultraviolet-visible absorption, and infrared spectroscopy. The conductance measurement indicates the non-electrolytic nature of the complexes. The octahedral environment has been proposed for the complexes except for Cd(II) complex. The level of toxicity of the synthesized complexes was determined in vivo. [Cu(ASA)(PABA)(H2O)2], [Cd(ASA)(PABA)]Cl2, and [Mn(ASA)(PABA)(H2O)2] exhibited higher enzymatic activities in the serum and kidney homogenates of the Wister rats investigated. The acetic acid-induced writhing model method was used in the evaluation of the analgesic activities of the prepared complexes. Metal complexes of Cu(II), Cd(II), Ni(II), Fe(III), and Mn(II) exhibited percentage writhing inhibition of 67.61, 43.87, 60.42, 70.45, and 52.34 % respectively. The complexes proved to be more effective than their parent-free ligands with Fe(III) possessing the highest analgesic potentials. The in vitro antimicrobial activity against bacterial strains was studied using the agar well diffusion procedure. It was also observed that the complexes exhibited higher bacteriostatic activities than the free ligands.Keywords: Acetylsalicylic acid, Serum chemistry, Para-aminobenzoic acid, Enzymatic activities, Antibacterial, Toxicity, Metal Complexes
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Background
Solanum erianthum leaves extract has been used to treat sexually-transmitted diseases, malaria, and leprosy. This study assessed the toxicity and safety of S. erianthum extract in rats.
MethodsTreatment with 250, 500 or 750 mg/kg of the aqueous, ethanolic and methanolic extracts in the rats had different effects on the biochemical activities of the liver, heart and kidneys, and based on the hematological and histopathological changes observed after short-term (30 days) and long-term (60 days) exposure.
ResultsThe serum biochemical parameters examined were AST, ALT, and ALP concentrations in the albino rats treated with the extracts of S. Erianthum at various concentrations. The extract showed significantly different effects in the treated versus untreated rats (P<0.05). The ALT level significantly decreased after the administration of 250, 500, or 750 mg/kg of the aqueous extract of S. Erianthum. There were significant differences in the hematological profile of the rats for all doses of the methanolic extracts (P<0.05). Histopathological examinations detected Kupffer cells activation in the liver, otherwise normal histology of the kidneys with respect to the glomeruli and tubules. Also, mild coronary vascular congestion was detected in the animals’ heart.
ConclusionThe S. erianthum extracts were safe and without exerting toxic effect on the rat’s heart or kidneys, as demonstrated for the doses up to 750 mg/kg given over 30 or 60 days. However, the congestion in the rats’ spleens could be a cause for concern if the extract were to be used in humans for long-term.
Keywords: Solanum erianthum, Hepatic macrophages, Serum chemistry, Toxicity, Sinus histiocytosis, Enzymatic activities
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