جستجوی مقالات مرتبط با کلیدواژه « severe acute respiratory syndrome coronavirus 2 (sars-cov2) » در نشریات گروه « پزشکی »

Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV2) leading to COVID-19 has initiated a catastrophe for humans since December 2019. Genetic and protein similarities between SARS-CoV and SARS-CoV2 offer the same treatments for both types of virus. However, there are some sequence or structural differences between SARS-CoV2 and SARS-CoV as well as other coronaviruses that make difficulties in discovering drugs and vaccines against this novel type of virus. Therefore, it is vital to recognize protein and genetic structures of SARS-CoV2 to discover drugs which directly target this strain of coronavirus. This review presents a perspective on SARS-CoV2, it’s genetic and protein structures with a brief comparison with other coronaviruses as well as summarizing some immune responses activated against SARS-CoV2. In addition, it introduces the novel strategies to combat with COVID-19 that would be potentially effective on SARS-CoV2.

Ever since the new coronavirus has become the cause of the COVID-19 pandemic, it has manifested with unknown and new presentations. In this report, we are presenting a 46-year-old female infected with COVID-19 (confirmed by RT-PCR nasal swab test) and a known case of Diabetes mellites type 2 who had a history of ICU admission due to COVID-19 with uncontrolled diabetes mellites. In the second admission after recovery, she had blurred vision. Fundus examination revealed multiple yellow-white well-demarcated nonpigmented masses. Diagnosis of the multiple subretinal abscesses was confirmed. KOH-Calcofluor staining of vitreous fluid was negative for fungal infections of the eye. No polymorphonuclear leukocytes (PMN), epithelial cells nor any organisms were detected. The patient was treated with an injection of the intravitreal Amphotericin B 10 µg/0.1cc.  To our knowledge, the presented case is the first case of the subretinal abscess after covid-19 infection.