جستجوی مقالات مرتبط با کلیدواژه « skin aging » در نشریات گروه « پزشکی »

Functioning as the human body's most extensive organ, the skin exhibits an intricate, stratified architecture. This architecture consists of distinct layers: the epidermis, dermis, and hypodermis. Collectively, these layers play a crucial role in safeguarding the body and upholding its general well-being. The aging process of the skin is complex and is influenced by a wide range of internal and external factors. The loss of skin elasticity and firmness is a consequence of these factors, which ultimately contribute to signs of aging such as wrinkles, skin discoloration, and diminished radiance as people get older. A comprehensive understanding of these factors and their impact on the skin can lead to the development of more effective methods and products for skin care, capable of slowing down this process and improving skin quality. Recent advances in nanotechnology, driven by increasing consumer demand for beauty products, have prompted the development of novel methods of skincare that are aimed at minimizing the appearance of symptoms of aging. Therefore, nanotechnology in skin care has emerged as a recognized novel and effective approach that can provide efficient solutions for combating skin aging. Nano lipid carriers have been introduced as one of the key innovations in this field. These carriers can effectively enhance the penetration of active cosmetic and skincare ingredients through the branched layers of the epidermis, which serve as the main barrier to the penetration of substances into the skin. These nanocarriers enhance the stability of active ingredients present in cosmetic and skincare formulations. When it comes to cosmetics and skincare products, nano lipid carriers have several distinctive qualities that add to their potential to improve efficacy while simultaneously minimizing side effects. They facilitate controlled release and long-term diffusion of active ingredients, ensuring continuous and uniform distribution of active compounds in the skin. Hence, they improve the biocompatibility of ingredients, thereby reducing skin irritation and enhancing skin tolerance to active substances. A wide range of nanocarriers is utilized in the dermal delivery of cosmetic and skincare products. These include nanoemulsions, liposomes, lipid nanoparticles, ethosomes, niosomes, transferosomes, nanocrystals, as well as polymeric and mineral nanocarriers. Each of these nanocarriers exhibits specific properties and mechanisms of action that effectively improve the penetration and efficacy of active ingredients into the deeper layers of the skin. In the present article, various types of nano lipid carriers have been examined as effective vehicles for delivering active compounds into the skin layers, along with their mechanisms of action. Furthermore, the latest anti-aging and anti-wrinkle products containing these nanocarriers have been discussed. Scientific investigations have demonstrated that the use of nano lipid carriers in the formulation of anti-aging products can significantly improve skin rejuvenation and regeneration. These products, by enhancing the permeability and stability of active compounds, exhibit better efficacy in reducing wrinkles and fine lines, increasing skin firmness and elasticity. It is also anticipated that with further advancements in this field, more innovative products will be introduced to the market to meet diverse consumer needs.

The concepts of Skin health and beauty, which are as ancient as mankind and civilization, are considered as the main factors of human health and well-being. Therefore skin anti-aging strategies as well as skin rejuvenation methods that prevent, delay, repair and combat skin aging and eliminate its symptoms and maintain the structural and functional integrity of the skin, are of particular importance. Skin aging is a complex and unpreventable biological process that occurs as a result of both intrinsic and extrinsic factors such as physiological, behavioral, geographical, and environmental and lifestyle factors. This dynamic and multifactorial process results from the formation and accumulation of reactive oxygen species (ROS) and the induction of matrix metalloproteinases. Skin aging is characterized by a progressive deterioration of the skinchr('39')s functional properties, linked to alterations in dermal connective tissue due to the changes at the cell, gene and protein levels. Different physiological and pathological processes involved in skin aging, are accompanied by clinical manifestations such as cumulative structural and physiological changes in skin structure and appearance, pigmentation changes, reduced elasticity, and increased wrinkles in the skin. Considering the increasing trend of aging in the world, and the growing interest to maintain a youthful appearance, the demand for skin rejuvenation practices has greatly increased to improve the quality of life (QOL), self-esteem, and improved body image among aging population. The skin rejuvenation process uses a combination of different methods of bio-revitalization and techniques for repairing and strengthening different layers of the skin, along with changes in some other factors such as lifestyle, emotional and health status in order to relieve the aging signs. Platelet-rich plasma (PRP), derived from fresh whole blood, is a biological product which contains platelets concentrated above baseline level. Activated platelet cells can be considered as vehicles for growth factors (GFs) and cytokine delivery, which play a crucial role in up-regulation of collagen production and controlling oxidative damage. Besides, GFs reduce the signs of aging by modulating cell migration, proliferation, differentiation, angiogenesis and chemotaxis. They can also stimulate collagen synthesis, reverse the effects of collagenases, increase extracellular matrix accumulation, and promote endothelial and epithelial regeneration. This issue has caused PRP to be used in multiple clinical fields such as orthopedics, regenerative sport medicine, plastic surgery, dermatology and aesthetic medicine, gynecology, ophthalmology, and dentistry, with remarkable results. Skin rejuvenation, dermal augmentation, hair restoration, and acne scaring, are some of PRP dermatological indications. Topical application or direct injection of PRP compositions into the dermis can be considered as one of the simplest biological interventions in the field of reconstructive medicine and aesthetic treatments because of their capability to function as vehicles for growth factors and cytokine delivery. GFs and cytokines have the potential to address skin aging through stimulation of cell regeneration. Different GFs including platelet-derived growth factor (PDGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF), present in PRP, stimulate human dermal fibroblasts. In fact Topical application of PRP or its direct injection into the skin, augment dermal elasticity by stimulating the removal of photodamaged extracellular matrix and induces the synthesis of new collagen and other matrix components by dermal fibroblasts via various molecular mechanisms. The ability of PRP to stimulate hyaluronic acid synthesis is another possible reason for skin rejuvenation. It should be noted that the topical application of Cosmeceutical formulations, containing biologically active ingredients, is preferable to invasive methods or systemic treatments. Because it is a safe, non-invasive, fast and simple procedure with the ability of topical delivery of active ingredient and direct impact on the desired location, fewer possible side effects and toxicities, and high user acceptability. Furthermore topically applied cosmeceutical preparations have advantages such as more solubility and spreadability, less drug degradation and enhanced bioavailability. Biocompatibility and biosafety, high clinical efficacy, fewer side effects, ease of use, non-invasiveness and greater acceptance and satisfaction of consumers, easier legal requirements, minimal manipulation, access to different methods of preparation, the possibility of adding different compounds to their formulation, reduced recovery time and downtime for patients, better aesthetic outcome, having antimicrobial activity and regeneration effect are some of PRP therapy benefits. However customizing PRP formulations for different clinical situations is an important challenge and should be carefully considered to achieve optimal efficacy, safety, tolerability, and stability. This article briefly discusses the concepts of skin health and beauty, skin aging and its clinical manifestations, classification of skin aging according to its causative factors, Skin rejuvenation strategies, mechanism actions of growth factors and platelet-rich plasma in skin rejuvenation, benefits of PRP therapies, Platelet preparation method, factors affecting the quality of PRP products, and formulation challenges. antibiotic resistance characteristics are determined and appropriate antibiotics are prescribed.