جستجوی مقالات مرتبط با کلیدواژه « synergistic action » در نشریات گروه « پزشکی »

Over the past two decades, the secondary metabolite platform has determined the scientific direction of herbal medicines, while plant sources have been assumed to be the object of lead discoveries through bioassay-guided fractionation efforts. Nonetheless, the majority of purification programs have resulted in fractions and pure compounds with much lower efficacy than their parent extracts. It is then assumed that co-working action modes among chemical constituents occur in the herbal preparations. Primary metabolites (polysaccharides, peptides, and fatty acids) and mineral groups, on the other hand, have been neglected in the herbal effect contributions. This review aims to understand the interplay of secondary metabolites in herbal preparations, particularly how they interact with primary metabolites and mineral groups. Thus, by adhering to classical methods, it is possible to address certain aspects that modern standardization lacks, thereby facilitating a more comprehensive approach to these issues.

Neurological disorders such as Alzheimer’s disease, Parkinson’s disease, dementia, epilepsy,depression, migraine etc. are affecting more and more elderly people’s day by day. Conventionalroute of administration to treat these diseases has to face a major hindrance that is bloodbrain and blood-cerebrospinal fluid (CSF) barrier to achieve desired concentration of drug atthe site of action for therapeutic effect. Hence, intranasal route of delivery is considered aspromising and alternative route to achieve desired goals. In last four decades, brain targetingstrategies are widely studied and considered having great potential by researchers; especiallyintranasal delivery owing to its benefits. Various nano formulations such as nanoemulsions,nanosuspensions, hydrogels, in situ gels, dendrimers and lipidic formulations are studiedwidely. Lipid nano formulations especially second generation nanostructured lipid carriersoffer greater advantages in terms of stability, fabrication techniques, scalability, drug loadingand drug targeting. Nanostructured lipid carrier (NLCs) constitute of two major componentsviz solid lipid and liquid lipid in a specific ratio. In this review, authors have discussed aboutthe possible synergistic actions of oils/liquid lipids with synthetic drugs resulting into greattherapeutic benefits.