جستجوی مقالات مرتبط با کلیدواژه "tcf7l2 gene" در نشریات گروه "پزشکی"

Gestational diabetes mellitus (GDM) is a type of clinical diabetes characterized by insulin resistance and impaired insulin secretion, due to environmental and genetic factors. The high risk of developing T2D in women with GDM and the high risk of developing GDM in women with a family history of T2D suggest that both diseases may have the same genetic basis. Therefore, genes and risk variants associated with the genetic architecture of T2D are being investigated for their effects on development of GDM. In our study, we aimed to investigate ABCC8, TCF7L2, Adiponectin, IRS1 and PPARG genes, which are known as T2D risk genes, in order to understand the genetic basis of GDM in Turkish population.

In our study, 74 pregnant women diagnosed with GDM according to ADA criteria and 49 healthy pregnant women were included. DNA isolations were made from periferal blood cells collected from pregnant women and regions of targeted genes were scanned by PCR-RFLP technique. In biochemical examinations; HOMA-IR, which is an indicator of insulin resistance, was calculated for each individual. The associations of genotypes detected in target gene regions with the disease and their effects on biochemical phenotypes were analyzed by establishing dominant, recessive and additive models and calculating odds ratios. P<0.05 was considered statistically significant in all analyses.

In our study, a statistically significant association was found between R1273R substitution in the ABCC8 gene and GDM under dominant and additive models. No statistically significant correlation was found between the A1369S and e16/-3t→c variants in the ABCC8 gene and the variants in other genes screened and GDM. When genotype-phenotype association data was evaluated, no association was detected between the all scanned variants and fasting blood sugar while a weak correlation was found with e16/-3t→c in ABCC8 gene and fasting insulin (p=0.075) and HOMA-IR (p=0.067).

ABCC8 (R1273R and e16/-3t→c) gene variants may be a risk factor for the development of GDM in the Turkish population.