جستجوی مقالات مرتبط با کلیدواژه « terbinafine » در نشریات گروه « پزشکی »

Dermatophytosis induced by Trichophyton mentagrophytes is a major human and animal fungal contamination. Antifungals like terbinafine and fluconazole are widely used to treat dermatophytosis; nevertheless, the prevalence of drug resistance has increased. Hence, novel curative strategies are needed. In the present study, we compared the efficacies of conventional and nanoform of antifungals agents in guinea pig model of dermatophytosis.

Guinea pigs (n=36) were injected (the posterior dorsal portion) with Trichophyton mentagrophytes conidia. The guinea pigs were divided into 6 groups (positive control, negative control, fluconazole 0.5% treated group, nano-fluconazole treated group, terbinafine 1% treated group, and nano-terbinafine treated group), then were scored both clinically (redness and lesion intensity) and mycologically (microscopy and culture) until day 40 of inoculation. The treatment started 5 days after the inoculation and continued until day 40 of inoculation.

Assessment of the mean score of clinical lesions in groups treated with nano-drug forms of fluconazole and terbinafine on the first day of treatment showed a score of 3 (significant redness with large scaling) and for the conventional form of terbinafine and fluconazole had a score of 4 (ulcer and scar). The decrease in lesion score in nano-drug treated groups was observed between days 15 and 20 and continued until day 40. On day 40, all groups had zero scores except the positive control group.

This study indicated that nano-drugs are more suitable for the treatment of dermatophytosis and could be considered as future alternatives for the treatment of dermatophytosis.

Terbinafine (TBF) is a drug with well-known antifungal properties effective against skin dermatophyte infections and nail particularly in treatment of pityriasis (tinea) vesicolor due to Malassezia furfur. Terbinafine topical administration is often recommended because commercial conventional terbinafine hydrochloride tablets are more expensive and have potential for significant adverse effects. Only less than 5% of terbinafine is absorbed in conventional topical forms. Novel nano-formulation approaches would be an efficient way to enhance penetration and abortion of topical drugs and eliminate limitations of conventional drug delivery systems. As conclusion, we believe that administering the Terbinafine in nano-formulations, according to different studies, could increases penetration of TBF through stratum corneum and viable epidermis and light the path of nano-structural delivery system in clinical application. Present overview aims to evaluate nano-strategies applied to improve permeation profile and terbinafine skin delivery.

One of the most important world wide zoonotic infection is dermatophytosis which caused by dermatophytes fungi. Dermatophytosis treatment minimizing the time course of the infection and the potential of spread to other animals and humans. The aim of  this study is to use the Artemisia sieberi nano-essence to treat dermatophytosis caused by Microsporum canis under experimental conditions in guinea pigs.

In this study guinea pigs randomly divided to 7 groups; negative control, positive control, terbinafine hydrochloride 1% and 4 different nano-essence concentrations treatment. 5 day after Microsporum canis suspension inoculation to abraded skin, treatment program for every nano-essence dilutions and terbinafine was started every 12 hours for 40 days.

Comparison of all nano-essence and terbinafine treatment groups on various days till 4oth day revealed no significant differences. Three consecutive culture results for all animals was negative on days 33, 40 and 50 in nano-essence groups but 16% of terbinafine groups was positive in fungi culture on day 33.

The results showed the nano-essence treatment groups showed improved clinical symptoms faster than the terbinafine treatment group over a shorter treatment period.