جستجوی مقالات مرتبط با کلیدواژه "tongue" در نشریات گروه "پزشکی"

 This study assessed the correlation of tongue posture with dental arch characteristics in sagittal and vertical skeletal patterns using cone-beam computed tomography (CBCT).

 This cross-sectional study evaluated 225 CBCT scans of sagittal Class I, II, and III patients. Class I and II groups were subdivided into high-angle, normal, and low-angle vertical subgroups. Palatal length, width, and height, maxillary width (Wmax), mandibular width (Wman), tongue posture according to the Graber’s analysis, tongue length (TGL), and tongue height (TGH) were three-dimensionally measured. Statistical analyses were conducted using one-way and two-way ANOVA, and Pearson and Spearman tests (alpha=0.05).

 All dental arch parameters were significantly greater in Class III, compared with Class I and II groups (P<0.05), except for) Wman, palatal length, and palatal height( . Palatal height was significantly greater in Class II and III, than Class I group (P<0.05). Wmax was lower in high-angle than low-angle, and palatal length was lower in high-angle than low-angle and normal groups (P<0.05). In Class I normal-angle patients, Wmax had a positive correlation with TGL. In Class I low-angle patients, Wmax had a moderate positive correlation with TGH.

 Significant differences were found in Wmax and palatal length among the vertical groups. In different skeletal patterns Wmax, Wman had a low to moderate positive correlations with D4, D5, D5ʹ, TGL and TGH. Wmax in Class I was significantly lower than that in Class III; this variable in Class II was significantly lower than that in Class III

The survival rate for oral tongue squamous cell carcinoma (OTSCC) is the lowest compared to other types of carcinomas in the oral cavity. This study aims to employ novel and robust methodologies based on bioinformatics techniques to identify differentially expressed genes in OTSCC tissues compared to normal tongue samples to shed light on the underlying causes of OTSCC. The dataset GSE13601 was obtained from the GEO, and the OPLS-DA method was applied to identify genes differentially expressed in OTSCC tissues compared to the normal healthy oral mucosa. A protein interaction map (PIM) was constructed, and hubs were identified. Survival analysis was performed to identify prognostic hub genes. The expression levels of the identified prognostic markers were evaluated at both mRNA and protein levels. Furthermore, bioinformatics web tools were used to perform pathway and GO annotation analyses. The study revealed 154 genes differentially expressed in OTSCC, with a statistically significant p<0.001 and a |Log2 fold change |>0.585. EIF2S1, EGF, NME1, NEDD8, EIF4A1, TOP1, and PSMA4 were found to have significant prognostic roles in OTSCC. The expression levels of all the identified prognostic markers were confirmed in HNSCC at the mRNA level and further validated the up-regulation of NME1, TOP1, and PSMA4 in HNSCC using immunohistochemical analysis. The FOXM1 was identified as the most important regulator of the hubs, while CDK2 was found to be the protein kinase acting on the transcription factors. The proteasome pathway and the regulation of ubiquitin-protein ligase activity were significantly enriched in OTSCC. This study provides valuable insights into the pathogenesis of OTSCC and may assist in improving the prognosis of OTSCC patients.

A granular cell tumor (GCT) is an unusual benign mesenchymal neoplasm with Schwann cells origin. The most common site is the dorsum of the tongue. It has a striking tendency to occur in females and is more frequent in adult patients. GCT typically shows an asymptomatic, slow-growing, single nodule. Histopathologically, it reveals a proliferation of polygonal cells with granular cytoplasm penetrating the adjacent muscles. In some cases, the overlying epithelium demonstrates pseudoepitheliomatous hyperplasia (PEH), which can complicate its precise diagnosis and may mimic squamous cell carcinoma (SCC). This paper presents a 58-year-old woman with a chief complaint of painless mass on the dorsal of the tongue for two years. The lesion was pink and circumscribed with firm consistency measuring 1×1cm. The surface of the lesion was intact. Microscopic examination demonstrated unencapsulated sheets of large, polygonal cells with abundant eosinophilic, granul-ar cytoplasm, and vesicular nuclei. The overlying epithelium showed florid PEH and keratin pearl formation. S100 protein was positive diffusely. The diagnosis of oral GCT was made. Though GCT is a non-aggressive lesion, it may be confused with SCC due to florid PEH and keratin pearl formation. Although PEH is a neglected topic among oral patholog-ists, it is of great importance in the field of research. Diagnosis can sometimes be problematic because they mimic other lesions. The pathogenesis of PEH is still uncertain. Therefore, familiarity with these characteristics and determining the cause of the PEH leads to correct treatment. This article intends to raise the insight of oral pathologists about PEH in oral lesions.

Hemangioendothelioma is a diverse set of proliferative and neoplastic vascular lesions with biological characteristics that fall halfway between benign hemangioma and malignant angiosarcoma. Hemangioendothelioma of the oral cavity is extremely rare and if present, it is seen on lips, gingiva, tongue, maxilla, and mandible. The following case report is about a lesion on the right ventrolateral border of the tongue of a six-year-old female patient. A Laser excision was done. Histopathology revealed the features of hemangioendothelioma. An immunohistochemical (IHC) study was done to correlate the findings with a histopathological picture and arrived at the final diagnosis of epithelioid hemangioendothelioma (EHE). The patient was followed up for two years and no recurrence was noticed.

The lingual abscess is rare due to several protective mechanisms against infection in this location. Concretely, the ab-scess in the base of the tongue (posterior lingual abscess) is even more exceptional. Its prompt detection is crucial toavoid potentially fatal airway complications. To familiarize physicians with this condition, we report 2 cases of posteriorlingual abscess. Both were referred to our emergency department due to minor oropharyngeal complaints. Finally, bothwere diagnosed and required surgical drainage. The clinical evolution was successful: both were discharged in less than72 hours and follow-up one week later confirmed clinical recovery.

The tongue is one of the most important organs in the oral cavity, and its lesions are a health concern for healthcare providers and patients. Limited epidemiological studies have evaluated tongue lesions in children. The present study aimed to evaluate the prevalence of various lesions on the tongue in a population of Iranian students. A total of 2051 students, aged 7–12 years, were randomly selected from elementary schools in Kerman using the random cluster sampling method from February 2020 to June 2020 for examination. The subjects’ age, gender, and identified tongue lesions were recorded in datasheets. The data were analyzed with SPSS software using the chi-square test and t test at a significance level of P < 0.05. Tongue lesions were identified in 29.9% of the children, and female children were affected at a higher rate than male subjects. The most frequent lesion was coated tongue, affecting 19.3% of the subjects, followed by partial ankyloglossia (3.6%) and fissured tongue (3.1%). The least frequent lesions were bifid tongue and microglossia (0.1% each). No cases of lingual thyroid were identified in the present study. Tongue lesions were identified at a relatively high frequency in children, necessitating general dental practitioners’ knowledge and awareness about the etiology, diagnosis, and management of these lesions.

Preoperative airway assessment is necessary to identify airway difficulties to the earliest, ensure adequate preparation to airway management before induction and to avoid airway related complications. Various Imaging techniques have been studied for prediction of the difficult airway. the ultrasound is a quick and simple technique. Aim of the study was to evaluate ultrasound guided measurement of tongue thickness in predicting difficult tracheal intubation in patients undergoing elective surgery.

Sixty-one patients American Society of Anesthesiologist class I and II,18-65 years of age, either sex, were included. Tongue thickness was measured by ultrasound as the distance from the surface of tongue to the submental skin. Modified mallampatti score was also recorded.

Receiver operating characteristic (ROC) curve of tongue thickness showed an AUC of 0.879 for a cut off value of >6 cm. This shows it has an excellent predictive value. Tongue thickness (>6cm) was found to have 90.16% combined diagnostic accuracy with 75% sensitivity and 94.74% specificity for prediction of difficult intubation. No correlation between tongue thickness and modified mallampatti score. (Correlation coefficient was 0.013, p value 0.920).

We conclude that ultrasound guided measurement of tongue thickness> 6 cm can reliably predict difficult tracheal intubation in patients undergoing elective surgery.

 This study aimed to determine the distance between the hard palate and the tongue and its relationship with Nasal Septal Deviation (NSD).

 This descriptive-analytical study was conducted on patients aged 18 to 60 years referred to the ENT clinic of Milad and Masih Daneshvari Hospitals. Patients were also divided into two groups (patients with and without NSD). Coronal CT scan was taken in all patients in the same position. In this regard, these pictures were taken vertically from the highest point of the hard palate to the tongue, the transverse distance between the two upper third molars of the upper jaw, and the ratio of these two distances.

 The mean age of patients with and without NSD was 35.82±12.49, and 33.99±12.78 years old (p=0.66). The distance of hard palate to tongue in patients with and without NSD was 13.05±4.52, and 12.26±4.68 mm, respectively (p=0.32). The intermolar distance in these patients was 34.2±3.50, and 34.40±3.31 mm (p=0.78), respectively. This ratio in the two groups was 0.38±0.13, and 0.34±0.11, respectively (p=0.16).

 According to these findings, no significant difference was observed between the patients with and without NSD regarding the distance between the hard palate and tongue, intermolar distance, and its ratio, but the distance of hard palate to tongue, and the ratio in the patients with NSD was slightly higher than patients without NSD. Further studies using coronal CT scan in larger samples are needed to clarify the role of the distance of hard palate and the tongue in NSD.

Neurofibromas, benign peripheral nerve sheath tumors, are the most common among neural lesion. Neurofibromas are rare in head and neck location, although it may involve any part of oral cavity. However, tongue is the most common region.

A 27 year-old man was admitted to Otorhinolaryngology Department due to a swelling in the base of his tongue, since two weeks before. This mass was painless, and without any associated symptoms. He was suffered from a mild eating disorder, too. He had no any positive past medical history, and only a large soft 6 × 5 cm mass was found at the base of his tongue without bleeding in the oral cavity. Excisional biopsy was performed for him under general anesthesia and the tumor was easily enucleated. The final diagnosis was neurofibroma. After the diagnosis of neurofibroma, the physical reexamination revealed a series of café au lait spots on his skin.

the neurofibroma should be considered by otorhinolaryngologist, as a differential diagnosis of tongue mass, and more accurate physical examination are recommended for better management.

Bisphenol-A (BPA) is one of the hazardous chemicals, which is extensively used. BPA can cause oxidative stress. Resveratrol (RES) is a natural polyphenol that possesses several health benefits, such as antioxidant effects.

This study aimed to investigate the protective effects of RES against BPA-induced oral mucosa and tongue toxicity.

A total of fivegroups of Sprague-Dawley male rats (n=30) were used in this study. Group 1 was the control group, and group 2 received 50 mg /kg BPA by gavage. Group3 was given 100 mg/kg of RES, and group 4 received 50 mg/kg BPA plus 100 mg/kg RES. In group 5, the sham group, the volume of the injectable drug received from olive oil was given as gavage for eight weeks. Following that, the paraffinized samples were sectioned in 5μm thickness to estimate the volume.

The results showed that BPA had a different effect on tissues. Moreover, the total volume of lamina propria, mucosal glands, the total glands of the tongue, volumetric density of the epithelium, andglands of the oral mucosaincreased in the BPA group, while in the BPA+RES group, these structures reduced, compared to the BPA group. In addition, the total volume of the epithelium of the tongue decreased in the BPA group, whereas this structure increased in the BPA+RES group, compared to the BPA group.

BPA has different effects on the oral mucosa and tongue. These effects can exert influence on the normal function of the cells in these areas. RES, with its antioxidant properties, had a protective effect on these structures against the BPA.

Lymphangioma is an unusual congenital malformation of the lymphatic system that affects the skin and subcutaneous tissue. A surgical procedure is among the options for lymphangioma treatment, although it can lead to significant complications. The Nd:YAG Laser appears to be one of the safest therapeutic options rarely proposed to treat oral cavity lesions. This paper comprehensively reviewed the studies published from 2010 to date on the treatment of cutaneous and mucosal lymphangioma with different types of lasers. In the current report, an 18-yearold female presented with a lymphangiomatous lesion on the tongue diagnosed through a pathologic study. The patient initiallyunderwent three sessions of pulsed-dye laser (PDL) therapy that evoked an insignificant response. Therefore, the approach was changed to long-pulsed Nd:YAG laser therapy, and a dramatic response was observed within three sessions of the treatment.

Many pathologic conditions can affect the tongue and their pattern of occurrence may differ. The objective of this study was the epidemiological survey of tongue lesions reported in a 10-year period in the Oral Pathology Department of Khorasgan Dental School.  In this cross-sectional study, 800 biopsy records were retrieved from the archives of the Oral Pathology Department of Khorasgan Dental School and examined. Moreover, the prevalence of lesions was investigated in terms of age and gender using descriptive statistics.  The prevalence of lesions analyzed in the present study was 4.37%. About 71.42% of the participants were female and 28.58% were male. Irritation fibroma had the highest frequency (20%). The most frequent lesion among women was lichen planus with a prevalence of 20% and the most frequent lesion among men was irritation fibroma with a prevalence of 30%. The highest frequency was observed in the age group of 21-30 years. Squamous papilloma, lichen planus, and irritation fibroma were the most common lesions with a prevalence of 25%. No lesion was detected in people aged 1-10 years.  In the present study, reactive lesions were the most prevalent tongue lesions. According to the findings, changing the lifestyle and observing oral hygiene seem to help prevent these lesions to a large extent.

Schwannoma is a benign neoplasm that arises from Schwannoma cells found in the peripheral nerve sheath. It's a frequent neoplasm in the head and neck area, but it's exceedingly unusual to find it in the mouth. It's a rare occurrence in the oral cavity of the pediatric age group. 

Case Report:

We present a 12-year-old kid who has had a smooth, firm, and non-tender mass in the sublingual region for the past year. The mass was removed completely using a transoral technique. The diagnosis of sublingual schwannoma was confirmed by histopathological and immunohistochemical testing.

Schwannomas are typically benign and have a good prognosis with a low risk of malignant change. It should be used as a differential diagnostic for sublingual diseases such as ranula and salivary gland lesions. In the case of lingual schwannoma, surgical removal of the tumor is the preferred therapy. The transoral method is the most popular treatment option for sublingual schwannoma.

Geographic tongue (GT) is one of the benign inflammatory oral diseases with unknown etiology.

The present study aimed to find the correlation between temperament (mizaj) and GT lesions in the context of Persian medicine and conventional approach.

In this cross-sectional study, 401 eligible participants were selected, 201 as the case group and 200 as the control group. After obtaining informed consent, the participants were asked to fill out a questionnaire. Then, the collected data were analyzed using SPSS, version 21.

Patients with GT were moderate regarding hot-cold temperament, and they had dry temperament. There was a statistically significant relationship between dry temperament and GT lesions (P value = 0.037). In the control group, people without GT lesion possessed average temperament either regarding hot-cold or wet-dry temperament. Moreover, there was a statistically significant relationship between hot-dry temperament and GT lesions (P value = 0.002).

The results of our study showed a higher frequency of GT in dry temperament. The dominant pattern for people with GT in compound and simple temperament was hot-dry and dry, respectively. The second more frequent temperament was hot. Following temperament change, treatment of GT lesion or alleviation of its disturbing symptoms is an issue, which might be determined by conducting basic research and well-designed clinical trials in the future.

Unilateral and bilateral tongue cyanosis usually occurs due to the Raynaud syndrome and in the underlying severe types of vasculitis and rheumatology.

The present study was conducted on a 54-year-old woman who referred to the emergency department with complaints of sudden and painless discoloration of the left half of the tongue. The patient had no history of disease other than diabetes controlled with glibenclamide. Clinical examination of the head and neck revealed evidence of unilateral cyanosis in the left half of the tongue without pain, whose discoloration did not improve with warming of the tongue.

Cyanosis in the emergency department can be managed appropriately by considering some parameters including history taking, history of cyanosis occurrence, history of cardiopulmonary disease, cold sensitivity and history of rheumatologic diseases, presence or absence of nail clubbing, arterial blood oxygen saturation and arterial blood gas test results. These parameters can be effective in designing a treatment regimen, while differentiating the causes of central from peripheral cyanosis.

Verruciform xanthoma (VX) is an uncommon benign lesion with the subepithelial accumulation of foamy histiocytes and superficial papillary proliferations with a bright orange hue. This lesion exhibits an oral region predilection.Its clinical differential diagnosis includes verrucous leukoplakia, verrucous carcinoma, squamous papilloma, verruca vulgaris, condyloma accuminatum, squamous cell carcinoma, and fibroepithelial polyp.

  Case Report: 

This report presents a case of VX of the ventral surface of the tongue afflicting a 33-year-old otherwise healthy male.

This case report can be valuable as a consequence of VX rarity and the similarity of its clinical features to papillary lesions. A biopsy is required for its definite diagnosis particularly when it occurs at sites with a high-risk of squamous cell carcinoma development, such as the lateral border and ventral surface of the tongue.

In this study, we compared regional recurrence in patients who had a dissection of levels I-III or levels I-IV. Patients with tongue SCC who were node-negative both clinically and radiologically, and underwent elective supraomohyoid neck dissection (SOHND) or extended supraomohyoid neck dissection (ESOHND) between March 2012, and March 2015 were retrospectively reviewed. The two therapeutic groups were analyzed for the incidence of tumor recurrence and survival. The two groups had statistically similar demographic qualities. Surgery duration and complications were the same in both groups. Complications mainly included internal jugular vein and thoracic duct injury. Tumour size was 46.2% T1, 40.4 % T2, and 13.3% Tx, being statistically similar in both groups. Tumour size had no meaningful correlation with the occurrence of occult neck metastasis in both groups. Local recurrence was more in ESOHND patients, but regional recurrence was similar in both groups. The survival rate was alike in both groups. No significant differences in tumor recurrence and mortality rate were found between patients treated with SOHND versus ESOHND. Thus, SOHND could be considered as a sufficient treatment for early-stage tongue SCC.

Head and neck squamous cell carcinoma (HNSCC) is the most frequent carcinoma of the head and neck region. For coverage of an entire resected mandible with floor of the mouth, 3/4 of the tongue and soft tissue of cheeks and neck bony reconstruction of the mandible and soft tissue reconstruction of tongue, cheeks and a neck large flap are needed. A patient with a superinfected T4 HNSCC was presented to our outpatient clinic. Complete resection of the mandible, bilateral neck dissection and 3/4 resection of the tongue were performed. A complex reconstruction using two free flaps was not feasable, so a large, folded, suprafascial Antero Lateral Thigh Perforator (ALTP) flap for immediate soft tissue reconstruction was used. Because of the anatomy, no reconstruction plate was inserted. On postop day 11, an understandable speaking was possible using a speach canula. Swallowing was possible without regurgitation. Eight months postoperatively, the patients mimic and closure of the mouth were satisfactory. The flap was viable throughout the entire time. It was shown that the suprafascial ALTP flap was a versatile part in the armamentarium for complex mandible soft tissue reconstruction.

Cerebral palsy (CP), a non-progressive brain disorder, occurs due to the destruction of the brain during its development and causes neuro-muscular disturbances. CP patients are highly susceptible to dental disorders. Here, we present a case of eosinophilic ulcer in the tongue of a boy who had CP with multiple carious teeth, for whom oral rehabilitation was carried out under general anesthesia.

A 16-year-old boy with CP presented to the Oral Medicine Department of Dental School of Semnan University of Medical Sciences with the chief complaint of chronic traumatic ulceration of the tongue. Because of the lack of his cooperation, after obtaining his parents’ informed consent, we decided to do the dental treatment under anesthesia. The intraoral examination showed that all of his teeth had severe caries with almost lost crowns. There was a horizontal incisor erupted toward his tongue leading to the tongue ulceration since two months ago. We started the extraction of the exposed roots of the mandibular teeth and then the maxillary roots. The antibiotics, analgesics, and mouthwash were prescribed. In a recall session two weeks later, the ulcer totally disappeared, but the contour of the tongue was depressed with the intact mucosa and no color changes.

Oral health problems in patients with CP may be neglected compared to their overall health management. The multidisciplinary approach is necessary for oral health care and may be defined as an essential scheme for improving their quality of life