جستجوی مقالات مرتبط با کلیدواژه « treponema pallidum » در نشریات گروه « پزشکی »
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BackgroundNeisseria gonorrhea and Treponema pallidum as an obligate human pathogen are two common causes of sexually transmitted diseases (STDs). The present study aimed to determine the prevalence of N. gonorrhoeae and T. pallidum among human immunodeficiency virus (HIV) patients in the southwest Iran.MethodsThis retrospective study was performed from 2004 to 2013, on HIV patients who were tested for detection of gonorrhea and syphilis infection at Shiraz HIV/AIDS Research Center. ELISA technique was used for preliminary detection of HIV and confirmed by a Western Blotting test. Gonorrhea was routinely diagnosed using direct Gram-staining and culturing on selective agar. Syphilis was routinely diagnosed by RPR test.ResultsOf the 806 HIV patients, 39 (2.6%) cases had co-infection with gonor rhea. Compared with mono-HIV infected patients, gonor rhea was significantly more likely among the males (69.4% vs. 92.3%, P=0.002). History of addiction and prison seems to be a significant risk factor for gonor rhea infection (P<0.05). Also, the mean of CD4+lymphocyte was higher among gonor rhea infected patients (368±238 vs. 415±328). Logistic regression analysis showed that sexual contact increased risk of gonococcal infection about 4 fold (OR: 4, CI: 1.7-9.39, P=0.001). None of the HIV patients had syphilis co-infection.ConclusionsAs a preliminary survey, our findings provided unique information on the prevalence of gonorrhea and syphilis co-infections among HIV patients. Moreover, we introduced the main risk factors associated with gonorrhea co-infection in HIV patients in our region including gender, history of addiction and prison, CD4+lymphocyte count, and transmission routes for effective management of STDs.Keywords: Sexually transmitted disease (STD), Human immunodeficiency virus (HIV), Neisseria gonorrhea, Treponema pallidum}
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BackgroundThe high prevalence of syphilis among inpatients is an important concern in clinical settings. Thus, a better understanding of the serological test would be valuable.ObjectivesWe analyzed the serological test results for syphilis among the inpatients in Wenzhou central hospital, China, to estimate the distribution of syphilis this Chinese population.
Patients andMethodsThe blood samples of 81946 inpatients at the hospital from January 2010 to December 2012 were collected and retrospectively analyzed. Syphilis testing was conducted using a Treponema pallidum enzyme-linked immunosorbent assay (TP-ELISA) and a TP particle agglutination (TPPA) assay. A toluidine red unheated serum test (TRUST) was then used to determine the titer of TP antibody in the TP- ELISA-positive samples.ResultsIn total, 1618 of the 81946 inpatients showed positive syphilis serology; the positive rates in 2010, 2011, and 2012 were 2.27%, 1.58%, and 2.11%, respectively. Males had a significantly higher positive rate when compared to females. Surprisingly, the highest positive rate was observed among patients older than 80 years, followed by patients younger than 19 years, while patients aged 20 - 39 years had the lowest positive rate. The TRUST titer of most TP-positive cases was less than 1:8. Patients aged 20 - 39 years showed the highest percentage of TRUST titer values ≥ 1:8, while patients older than 80 years showed the lowest percentage; the differences between these two groups were statistically significant.ConclusionsThe serological characteristics of syphilis varied with gender and age. Syphilis screening and control should be conducted for young patients and pregnant women, but special attention should also be paid to elderly inpatients. The TRUST assay is better used in syphilis screening and for judgment of curative effects, but the diagnosis needs specific methods, such as the TP-ELISA and the TPPA test.Keywords: Syphilis, Inpatient, Serologic Test, Treponema pallidum} -
سیفلیس یکی از بیماری های عفونی است که می تواند هر یک از ارگانهای بدن را مبتلا نمای و علائم بسیاری از دیگر بیماری ها را تقلید نماید. بدین لحاظ از زمانهای گذشته این بیماری مقلد بزرگ (grate imitator) نام گرفته است. تظاهرات این بیماری در سیستم قلبی عروقی و سیستم اعصاب مرکزی حایز اهمیت ویژه ای می باشد. در این مقاله بیماری معرفی می شود که با تشخیص آنوریسم آئورت جراحی شد و ترمیم آنوریسم بشیوه ای خاص و بدون استفاده از پیوند graft انجام پذیرفت. آزمایشهای سرولوژی ، ایمونوفلوئورسانس و آسیب شناسی تشخیص آئورتیت سیفلیسی را تائید نمودند که پیامد آلودگی قدیمی بیمار به ترپونماپالیدوم بود.کلید واژگان: آنوریسم آئورت, آئورتیت سیفلیسی, ترپونما پالیدوم}Syphilis is the infectious disease that named "great imitator" because can imitate manifestations of other diseases and can involve any organ in body. Late manifestations of syphilis in cardiovascular system and central nervous system (eNS) are important.
A case of huge syphilitic aortic aneurysm who visited in Shahid Rajai Hospital, is being reported. The Patient underwent surgery under general anesthesia, Anatomic repair of the thoracic aortic aneurysm was done without any graft. Immunofluorescence test and pathologic study were in favour of syphilitic aortitis, the late manifestation of Treponema Pallidum infection.Keywords: Aortic aneuysm, Syphilitic aortitis, Treponema Pallidum}
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