جستجوی مقالات مرتبط با کلیدواژه « urea breath t » در نشریات گروه « پزشکی »

Helicobacter pylori (H. pylori) is identified as the most frequent agent of bacterial infections in humans which can cause various gastrointestinal diseases. This pathogen has infected approximately half of the world’s population, and its outbreak has varied across different regions. The purpose of this study was to estimate the H. pylori infection prevalence amongst patients in Fardis county, Alborz province, Iran, using noninvasive methods.

A total of 5677 patients were analyzed from September 2020 to October 2021 to detect H. pylori by the use of enzyme-linked immunosorbent assay (ELISA) IgG, IgA, and IgM tests, stool antigen test (SAT), and urea breath test (UBT).

Of 5677 patients, 3486 (61.4%) were female and 2191 (38.6%) were male with the mean age of 38.82 ± 18.289 years old. The overall rate of H. pylori infection positive was 31.46%, and the serological tests were the most prescribed types of tests. The IgG test and then SAT detected the most positive cases. Further, the infection rate was significantly associated with age. Except for the case of IgM, which was higher in females compared to males, no significant difference was found between gender and bacteria outbreak.

This study indicated a decline in H. pylori infection prevalence compared with the prior survey conducted at this center. However, its rate amongst the patients referring to Fardis laboratory is still high.

Helicobacter pylori are the most common gastrointestinal in-fection worldwide. Determination of contributing factors for successful eradication of Helicobacter pylori is important for better infection control. Therefore, this study was conducted to investigate the association between serum vitamin D deficiency and He-licobacter pylori eradication rate.

In this nested case control study in Loghman Hospital in Teh-ran in 2018 and 2019, 200 consecutive patients with Helicobacter pylori infection using amoxicillin, pantoprazole, bismuth, and metronidazole for 4 weeks were enrolled. The serum vitamin D level was compared across the groups with successful (n=153) versus unsuccessful (n=47) eradication of infection. Finally, data analysis was performed us-ing SPSS statistical software version 25 and the mean, standard deviation, frequency, percentage and statistical test of Chi-square were used to describe and analyze the data and the significance level in this study was less than 0.05.

The results of this study demonstrated that before-treatment vitamin D level was between 10 and 20 ng/dL in majority of unsuccessful cases (40.4%) and it was more than 30 ng/dL in majority of successful cases (83.7%) showing statistically signif-icant difference (P < 0.001).

This study showed a significant association between vitamin D deficien-cy and Helicobacter pylori eradication and low vitamin D level resulted in failure of treatment; Hence in unsuccessful cases, assessment of vitamin D level and possible supplementation in those with hypovitaminosis D is recommended.

Different studies have investigated the link between helicobacter pylori and extra digestive diseases such as idiopathic thrombocytopenic purpura. However, the relationship between ITP and H pylori is less clear. Most of the studies have focused on H pylori eradication in chronic ITP, so we focused on the effect of H pylori eradication on chronicity of ITP in adult patients with ITP.

Eighty five patients with acute ITP whose platelet count were less than 30x109/L were enrolled to the study. Urea breath test (UBT) was carried out for all the patients and based on its results; the patients were divided into 3 groups: Group I: H pylori positive patients who underwent standard triple therapy. Evaluation of H pylori eradication for this group was carried out one month and six months after the treatment. Group II: ITP patients negative for H pylori and Group III: ITP patients' positive for H pylori but without eradication therapy.

52(61.2%) patients were female and 33(38.8%) were male with mean age of 34.8±12.2 years. There was no significant difference between the mean age and gender in different groups. No significant difference was seen in mean platelet count at the baseline among the groups, but there was a significant statistical difference in mean platelet between the groups at the end of the first month. However, a significant difference was not seen in mean platelet count in months 2 to 6. Chronicity in group I was statistically less than the group III. Also, the chronicity rate in non-infected ITP patients was lower than the H pylori positive patients (P=0.03). Likewise, the chronicity rate was lower in the intervention group than in the control group (P=0.035).

Our results show that eradication of H pylori can reduce the chronicity rate in adult patients with ITP. Further studies on larger number of patients with longer follow-up are recommended.