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عضویت

جستجوی مقالات مرتبط با کلیدواژه "urinary bladder neoplasm" در نشریات گروه "پزشکی"

جستجوی urinary bladder neoplasm در مقالات مجلات علمی
  • Maryam Khayamzadeh, Fereshte Aliakbari, Zahra Zolghadr, Majid Emadeddin, Mahsa Ahadi, Mohammadesmaeil Akbari, Amir Reza Abedi *, Shahrzad Nematollahi, Seyed Jalil Hosseini
    Background & Objective

    Bladder cancer is the fourth most common cancer in men and the most common cancer in women, comprising 8% of all males and 3% of female tumors. The present study aimed to estimate the five-year survival rates of bladder cancer in Iran.

    Methods

    Information on3,337 registered cases of bladder cancer was obtained from the Office of National Cancer Registry in the Ministry of Health and Medical Education (MOH & ME). A telephone survey was conducted to gather additional information, such as survival status, demographic, and clinical profile. Kaplan–Meier estimates of five-year survival rates were calculated according to the age of diagnosis, gender, pathological type, and provincial pole. Results and

    Conclusion

    Overall five-year survival rate was 77%. According to the pathologic type, five-year survival rates were 81%, 66%, 81%, 42%, 77%, and 82% in low-grade urothelial carcinoma, high-grade urothelial carcinoma, adenocarcinoma, undifferentiated carcinomas, Squamous Cell Carcinomas (SCCs), and other tumors, respectively. Additionally, those tumors  were 93%, 88%, 81%, 64%, and 44% among patients whose average ages at diagnosis were < 50, 50–59, 60–59, 70–79, and > 80 years old, respectively. Our study revealed that age and histological type were the major prognostic factors for survival in patients with bladder cancer. Therefore, given the histologic features of the tumor and patients with advanced age, a continuous screening would be highly warranted.

    Keywords: Urinary bladder neoplasm, Survival analysis, Iran, Disease registry
  • Saeid Afshar, Saman Seyedabadi, Massoud Saidijam, Pouria Samadi, Hamzeh Mazaherilaghab, Ali Mahdavinezhad*

    Long non-coding ribonucleic acids (lncRNAs) are the largest group of non-coding RNAs,supposedlyhave a broad spectrum of diverse functions in normal cellular processes. This study was carried outto review the biological functions of candidate lncRNAs (i.e.,H19,MALAT-1,TUG1,UCA-1,MEG3,HOTAIR,CCAT2,AATBC,and the like) with aberrant expressions that play critical roles in bladdercancer (BC) initiation,progression,and metastasis. A formal narrative review was performed by searchingthe PubMed database for English articles using a combination of keywords such as “long non-codingRNA”,“lncRNA”,“cancer”,“bladder cancer”,“screening”,“prognosis”,“diagnosis”,and “response totherapy”. In addition,the existing literature was studied on biological function,aberrant expression,and the clinical applications of candidate lncRNAs in BC. By a better understanding of the molecularmechanisms of lncRNAs,they can be used as biomarkers for tumor signatures in urologic malignancies,which can improve screening,prognosis,diagnosis,and the treatment of BC.

    Keywords: Biomarkers, Long non-coding, RNA, Urinary bladder neoplasm
  • Shima Hosseini, Massoud Saidijam, Hamid Eslami, Ali Reza Soltanian, Seyed Habibollah Mousavi, Bahar, Ali Mahdavinezhad *
    Background
    Numerous molecular changes are involved in the development andprogression of bladder cancer. Regular follow-up of patients is crucial due to the highrecurrence rate of bladder cancer. The aim of this study is to determine the role ofB-Raf proto-oncogene, serine/threonine kinase and ZEB2 expressions in onset andprogression of bladder cancer. We have also investigated their relationships topathological characteristics.
    Methods
    We conducted this case-control study on bladder cancer and its healthyadjacent tissue, and normal bladder tissue from patients with benign prostatic hyperplasia.After extraction of total RNA and cDNA synthesis, quantitative expression analysis wasperformed in duplicate using real-time PCR. Changes in the gene expression werecalculated according to the 2(-ΔΔCt) equation. The products were confirmed by 1% agarosegel electrophoresis and sequenced by Bioneer Company. Data was analyzed using theSPSS software (version 16).
    Results
    There was significantly greater B-Raf proto-oncogene, serine/threoninekinase expression in 82% of bladder tumor samples compared to the adjacent tissues.In 91.1% of tumor samples, the gene expression was also significantly higher than healthybladder tissues from patients with benign prostatic hyperplasia. We observedoverexpression of B-Raf proto-oncogene, serine/threonine kinase in 61.7% of thehealthy margin tissue samples compared to healthy bladder tissues of patients with benignprostatic hyperplasia (P<0.001). Expression of ZEB2 in 52.9% of the bladder tumorsamples was significantly higher than healthy peripheral tissues. This increase wasobserved in 94.1% of tumor samples compared to healthy bladder tissues of patientswith benign prostatic hyperplasia (P<0.001). Pearson correlation coefficient showeda positive relationship between B-Raf proto-oncogene, serine/threonine kinase and ZEB2in cancerous samples (r = 0.75) and healthy margin tissue samples (r = 0.49).
    Conclusion
    During the carcinogenesis process, molecular changes are seen inhealthy margin tissue. These molecular changes may be the reason for the highrecurrence rate of bladder cancer. B-Raf proto-oncogene, serine/threonine kinase canpotentially be a target cancer therapy in antisense technologies.
    Keywords: Biomarkers, BRAF, ZEB2, Urinary bladder neoplasm
  • Mohammad Reza Darabi, Ali Reza Khoei, Atena Aghaee, Salman Soltani *

    Introduction: Urachal adenocarcinoma is an invasive and rare bladder carcinoma that usually presents at advances stages with poor prognosis. The symptoms often include abdominal pain and hematuria. The standard treatment method is surgical excision of the tumor and sometimes, in advanced cases, chemotherapy is needed, too. Case Presentation: We present a 35-year-old male patient, who referred with acute onset of painless macroscopic hematuria. Pelvic CT scan showed a large mass on the bladder dome, extending to the umblicus. Biopsy of the mass confirmed that the pathologic diagnosis was urachal adenocarcinoma. The patient was then treated surgically with partial cystectomy approach. Conclusions: Despite microscopic involvement of pelvic lymph nodes, adjuvant therapy was not intended. There were no local recurrence or distant metastasis in long term close follow up

    Keywords: Urachal Carcinoma, Urinary Bladder Neoplasm, Signet Ring Cell Carcinoma, Bladder
  • Ali Mahdavinezhad, Seyed Habibollah Mousavi-Bahar, Jalal Poorolajal, Rezai Yadegarazar, Mohammad Jafari, Nooshin Shabab, Massoud Saidijam
    Bladder cancer (BC) ranks the second most common genitourinary tract malignant tumor with high mortality and 70% recurrence rate worldwide. MiRNAs expression has noticeable role in bladder tumorigenesis. The purpose of this study was to assess miR-200c, miR-30b and miR-141 in tissue samples of patients with BC and healthy adjacent tissue samples and their association with muscle invasion, grade and the size of the tumor. Transurethral resection tissue samples were collected from thirty- five newly diagnosed untreated patients with BC from 2013 to 2014. The control group consisted of adjacent normal urothelium. All samples, observed by two pathologists, were diagnosed transitional cell carcinomas (TCC) with the proportion of tumor cells greater than 80%. Total RNA including miRNAs was extracted from about 50 mg tissue samples by applying TRIzol reagent. 2(-ΔΔ CT) method was used to calculate relative quantification of miRNA expression. Two of 35 patients were females and the other 33 were males. Invasion to bladder muscle was observed in 23 (67%) cases. MiR-141, miR-200-c and miR30-b were up-regulated in 91%, 79% and 64% of malignant tissues, respectively. Down-regulation of miR-141 had a strong association with muscle invasion (P= 0.017). Significant inverse correlation between grading and miRNA-141 level was observed (P= 0.043).
    Keywords: Urinary bladder neoplasm, microRNA, 200c, microRNA, 141, microRNA, 30b, neoplasm grading, neoplasm invasiveness
نکته
  • نتایج بر اساس تاریخ انتشار مرتب شده‌اند.
  • کلیدواژه مورد نظر شما تنها در فیلد کلیدواژگان مقالات جستجو شده‌است. به منظور حذف نتایج غیر مرتبط، جستجو تنها در مقالات مجلاتی انجام شده که با مجله ماخذ هم موضوع هستند.
  • در صورتی که می‌خواهید جستجو را در همه موضوعات و با شرایط دیگر تکرار کنید به صفحه جستجوی پیشرفته مجلات مراجعه کنید.
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