جستجوی مقالات مرتبط با کلیدواژه « urtica dioica » در نشریات گروه « پزشکی »

Diabetes has harmful effects on the vascular structure and angiogenesis of various organs, including the hippocampus. In this regard, this study was designed to investigate the effect of non-pharmacological interventions of endurance training (Ex) and Urtica dioica (UD)  plant hydroalcoholic extract on the stereological changes of the hippocampal capillaries of diabetic rats. 35 Wistar male rats were divided into 5 groups: Healthy control, Diabetes control, Diabetes+Ex, Diabetes+UD, Diabetes+Ex+UD. Diabetes was induced by intraperitoneal injection of streptozotocin. The Ex protocol with moderate intensity and daily gavage of UD hydroalcoholic extract was implemented for six weeks. 48-h after the last session, the rats was sacrificed, and then the hippocampal tissue was removed and placed in 10% formalin for hematoxylin-eosin staining. The stereological changes of the hippocampal tissue were investigated in the parameters of the number of vascular sections, length, volume and area of capillaries. Data analysis was done using repeated measures ANOVA tests for blood glucose variable and Kruskal-Wallis test for stereological studies of hippocampal tissue. Diabetes caused a significant decrease in the number of vascular sections, length, volume and area of hippocampal capillaries (P<0.001). Thus, all stereological parameters in the combined group of Ex+UD were better than the groups that implemented only one of the interventions (P<0.05). The changes of Ex and UD groups in stereological parameters of hippocampal tissue after 6 weeks were not significant. The results obtained in  combination effectiveness of Ex and UD on the stereological parameters of the hippocampal tissue of diabetic rats promise to improve the health of the vessels and angiogenesis of the hippocampal tissue by changing the lifestyle of diabetic people.

Exercise interventions combined with medicinal plants are effective in preventing or reducing cancer symptoms and side effects caused by cancer treatment. The aim of this study was to investigate the effect of interval training and consumption of Urtica dioica hydroalcoholic extract on selecteted factors of immune and growth in C57BL/6 rats with melanoma cancer.

In this experimental study, 20 C57BL/6 rats were randomly divided into four groups include control (cancer), Urtica dioica (cancer), and Urtica dioica - interval training (cancer). Experimental groups received nettle extract of 30 mg daily per kilogram of body weight. The interval exercise program included running on a treadmill 60 minutes at a speed of 28 meters per minute, five days a week for six weeks. Levels of nucleotide exchange factor (Apg-2), heat shock protein 70 (HSP70), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed death protein-1 (PD-1), insulin-like growth factor-binding protein 2 (IGFBP2) of rats was measured by Real Time PCR method. The data were analyzed and analyzed by One -way variance analysis and the Toky's test at the P<0.05.

interval training led to significant increase in gene expression of APG2, CTLA4 and decrease in IGFBP2 (P<0.001). Urtica dioica extract led to significant decrease in IGFBP2 (P<0.010). interval training with Urtica dioica extract led to significant increase in gene expression of APG2 and decrease in IGFBP2 compared to the Urtica dioica group (P<0.001). There was no significant difference between the mean of PD-1 gene expression in different groups (P=0.158).

According to the results, interval training with Urtica dioica hydroalcoholic consumption has more advantages in regulating gene expression of some growth and immune factors in melanoma cancer than interval training and Urtica dioica consumption alone.

Use of medicinal plants is considered as a safe and effective alternative treatment for hyperglycemia. In addition to the positive effects of exercise on diabetic patients. This study aimed to investigate the effects of Urtica Dioica (UD) and Swimming activity on the kidney Properties in diabetic rats

Materials: 

Adult male rats were randomly distributed in nine groups: intact control, diabetic control,diabetic + 625 mg/kg, 1.25 g/kg UD, diabetic + 100 mg/kg Metformin, diabetic + swimming, diabetic + swimming 625 mg/kg, 1.25 g/kg UD, and diabetic +100 mg/kg Metformin + swimming. Aqueous extract of  Urtica Dioica was given to rats by gavage for 4 weeks. Swim training protocol was performed for 4 weeks, 5 days per week. Blood bilirubin, albumin, creatinine and uric acid were determined. Renal tissue changes were examined in different experimental groups.

Bilirubin levels in metformin group, diabetes with swim training group, swim training with metformin group, UD extract at a dose of 1.25 g/kg group, UD extract at a dose of 625 mg/kg  group, UD extract at a dose of 1.25 g/kg with swim training group, UD extract at a dose of 625 mg/kg with swim training with diabetic control group showed a significant increase (p<0.05). Albumin, creatinine and uric acid levels compared to diabetic control group were not significantly different.

The present results show that swimming training with Urtica Dioica extract has beneficial effects on renal tissue changes in diabetic rats and these effects are dose dependent.

Oxidative stress plays a key role in the onset and development of diabetes-related complications. Due to the antioxidant effect of exercise and Urtica dioica (UD), this study aimed to evaluate the effect of one period of endurance exercise and hydroalcoholic extract of Urtica dioica on oxidative stress indices of heart tissue in STZ-Induced diabetic rats.

In this study, 50 Wistar rats (mean±SD weight: 232.12±7.42 g) were randomly divided into five groups: Healthy-sedentary, Diabetes-sedentary, Diabetes-Exercise, Diabetes-Urtica dioica, and Diabetes-Exercise-Urtica dioica. Diabetes was induced by intraperitoneal injection of streptozotocin (45 mg/kg) and 48 hours after injection, blood glucose levels above 300 mg/dl were the criteria for the confirmation of diabetes. Endurance exercise with moderate intensity (5 days/week) and daily gavage of hydroalcoholic extract of UD was performed at 50 mg/kg for six weeks. Data were analyzed in SPSS software (version 20) through Shapiro-Wilk, two-way ANOVA, and Tukey post hoc test.

Two weeks after STZ injection, body weight in the Diabetes-Urtica dioica (P=0.001), Diabetes-Exercise (P=0.034), and Diabetes-Exercise-Urtica dioica (P=0.025) groups decreased, compared to the Healthy-sedentary group, and this reduction continued until the end of the sixth week. In addition, six weeks of endurance exercise and UD extract significantly reduced blood glucose concentration in the Diabetes-Exercise (P=0.001), Diabetes-Urtica dioica (P=0.001), and Diabetes-Exercise-Urtica dioica (P=0.001) groups, compared to the Diabetes-sedentary group. Furthermore, endurance training and UD extract caused a significant increase in catalase (P=0.019) and glutathione peroxidase (P=0.028) values and a significant decrease in heart tissue malondialdehyde (P=0.001).

Six weeks of endurance training combined with UD extract can increase the antioxidant index and decrease lipid peroxidation in the heart tissue of diabetic rats with streptozotocin.

Postpartum hemorrhage is the most leading cause of maternal mortality worldwide; prevention of it can be effective in reducing mortality and complications. Studies have shown the contractile and anti-inflammatory properties of Urtica dioica and its effect on reducing menstrual bleeding, so the present study was performed aimed to determine the effect of Urtica dioica drops on postpartum hemorrhage.

This triple-blind randomized clinical trial study was conducted in 2019 on 100 women referred to Kamali Hospital in Karaj (Iran) for vaginal delivery in two groups of intervention and control. The intervention group received 10 drops of Urtica dioica and the control group received 10 placebo drops after delivery. Bleeding was measured using PBLAC chart up to 24 hours after delivery. Hemoglobin and hematocrit levels were measured at arrival and 6 hours postpartum. Data were analyzed using SPSS software (version 20) and independent t-test, Mann-Whitney, Fisher, Chi-square and repeated measures ANOVA. P<0.05 was considered statistically significant.

There was no statistically significant difference between the two groups in terms of demographic and obstetric variables (p>0.05). The mean of bleeding in the first 24 hours after delivery was 55.94±11.55 ml for the intervention group and 71.48±12.45 ml for the control group, which was significantly different (p=0.001). Also, the mean decrease of hemoglobin (p = 0.006) and hematocrit (p = 0.001) level was significantly lower in the Urtica dioica group than the control group.

Urtica dioica drop have a significant effect on reducing bleeding and reducing hemoglobin and hematocrit after childbirth and is helpful in reducing postpartum hemorrhage.

The role of tumor suppressor genes in the development of prostate cancer is well known. Decrease or lack of expression of these genes causes the tumor to spread through metastasis to other tissues of the body. Since nettle has anti-cancer effects, the aim of this study was to investigate the effects of hydroalcoholic extract of nettle stem and root on the expression changes of PTEN, MAGI-2 and SMAD-2 genes in mouse prostate induced tumor.

In this experimental study, hydroalcoholic extract of nettle was prepared by Soxhlet apparatus. The mice were injected subcutaneously for 28 days after injection of DMBA carcinoma with doses of 75 and 250 mg/kg, respectively. Also, the control group received no drug and the sham group received only the extract. The expression changes of the target genes were analyzed by Real Time PCR and the results were analyzed statistically.

The results showed that PTEN gene expression was increased in treatment with 250 root extract compared to day 14 turmeric. Expression of MAGI-2 gene was increased in treatment with root extract of 75 dose on day 28 compared to day 28 tumor. Evaluation of SMAD-2 gene expression showed that expression of this gene in treatment group with 250 root extract increased on day 21 compared to day 21 tumor.

According to studies on PTEN, MAGI-2 and SMAD-2 have revealed that inactivation of these three genes is considered a risk for cancer progression.

The emergence of resistant fungal species, as well as relatively high side effects of antifungal drugs, have prompted researchers to develop new methods forcing action against fungi. The aim of present study was to evaluate the antifungal effects of hydroalcoholic extracts of Nigella sativa and Urtica dioica on Candida species isolated from clinical specimens in comparison with amphotericin B.

In the current study, antifungal effect of hydroalcoholic extracts of Nigella sativa and Urtica dioica, which were prepared by soaking and soxhlet methods, against 11 Candida isolates (Candida albicans and Candida parapsilosis), were measured using broth microdilution method. Candida isolates were exposed to different concentrations of the extracts, and the minimum inhibitory concentration (MIC) of each extract was determined.

Both hydroalcoholic extracts of Nigella sativa and Urtica dioica showed antifungal effects against candida isolates. The MIC90 values of soaked and sox let hydroalcoholic extracts of Nigella sativa for Candida albicans and Candida parapsilosis were 25 and 12.5 mg/ml, respectively. Moreover, MIC90 values of soaked and sox let hydroalcoholic extracts of Urtica dioica for the candida species in both methods were 12.5 mg/ml. In addition, MIC90 values of amphotericin B against Candida albicans and Candida parapsilosis were obtained 1.0 and 0.5 μg/ml, respectively.

Although amphotericin B as an effective drug has a better antifungal effect against candida species, hydroalcoholic extracts of Nigella sativa and Urtica dioica also have acceptable antifungal effects on Candida albicans and Candida parapsilosis. Among them, Urtica dioica extract has a better effect than Nigella sativa extract.

One of the goals of medical science in current communities is wound healing in shorter time and with less side effects. The nettle extract in the presence of chitosanchr('39')s natural polymer can have antimicrobial and repairing properties. It also improves the recovery speed with less complications and less time.

For different tests, we produced a chitosan film with different percentages of 10%, 20%, 40% of nettle extract and a control sample without plant extracts. These tests include scanning electron microscopy (SEM), percentage of water absorption, antibacterial properties, percentage of inflation, degradability rate.

The sample with high percentage of plant extract had a higher porosity surface than other samples and could be considered as a suitable wound dressing. Using two gram positive bacteria (Staphylococcus aureus) and gram negative (Pseudomonas aeruginosa) from the body of patients in Taleghani Hospital of Tehran to evaluate the antimicrobial activity of the film containing nettle extract and chitosan was used. The results of Staphylococcus aureus bacteria are better than Pseudomonas aeruginosa. Results were calculated with Prism software.

A wound dressing should be capable of absorbing extra secretions from the wound, antibacterial, smoot cutting without damaging the wound , biodegradable. The results of this study indicate that the wound dressing prepared in this project can have the conditions of an ideal wound dressing.

Diabetes is the most common metabolic disease worldwide. Due to the arbitrary use of Urtica dioica among diabetics, this study aimed to investigate the effect of this herb on the control of diabetes.

This review study was performed using the Persian and English keywords, such as "type 1 diabetes and 2", "insulin", "herbal medicine", and "Urtica dioica" among valid databases, including PubMed, Elsevier, Wiley, Science Direct, and SID from 2000 to 2019. Subsequently, out of 127 articles, the results of 16 studies were examined in this review.

The mechanisms investigated in these studies included DNA damage, increased numbers of beta-cells, increasedexpression of GLUT4 on the muscular cell surface, inhibition of atrophy of beta-cells, rearrangement of histology of isletsofLangerhans, and stimulation of insulinsecretion. Few positive results have been reported in the clinical models of diabetes on this extract.

According to the current study, Urtica dioica extract can control blood glucose levels through different mechanisms. Further studies with a wider number of samples to evaluate the exact mechanism of this extract on clinical specimens (in patients with type 1 and 2 diabetes) with and without insulin consumption and dosage are among the important issues in evaluating the effect of this extract

Multiple Sclerosis (MS) is a neurologic necrotic and chronic illness that causes by demyelination in CNS. One of the common clinical symptoms in MS is cognitive disorders. The most common cognitive defects in patients with MS are reduction of memory and information processing rate hippocampus functions in brain are memory and learning. This study was done to determine the function mechanism of memory discover by study on hippocampus. Nowadays tendency of herbal therapy is increased because of drug's side effects. This study's purpose that is from experimental typ effect of compaind extract of Portulaca olerace, Urtica dioica and Boswellia serrata on memory and number of neurons in CA1 area of hippocampus in induced multiple sclerosis rats. In this experimental study 30 male adult rats were randomly allocated into control group, sham group (salin injection), (MS + salin) group, (MS + mixture extract, dose of 200 mg/kg), (MS + mixture extract, dose of 400 mg/kg). MS model was induced by intra hippocampal injection a single dose of ethidium bromide (0.01% ethidium bromide sulotion in 0.9% salin) and in 3 microlitre volume with 1 microlitre in minute rate intraperitoneally. Compaind extract of Portulaca olerace, Urtica dioica and Boswellia serrata were injected as the treatment for 21 days. The shuttle box test was used for evaluation of memory. Dissector method was used for neural density in CA1 of hippocampus. Histopathology method was used for evaluation of the alteration of cells. Neural density in MS induced group was singnificantly reduced in comparison with control and sham groups (P<0.05). Neural density was singnificantly increased in treatment groups in comparison with MS induced group (P<0.05). Histological results showed that induction of MS caused the disrution of neuron cells in compare to controls, but intraperitonal injection of compaind extract cause neurogenesis in tertment groups. Memory in MS induced group was singnificantly reduced in comparison with control and sham groups (P<0.05), but memory was singnificantly increased in treatment groups in comparison with MS induced group (P<0.05). Compaind extract of Portulaca olerace, Urtica dioica and Boswellia serrata with dosages of 200 and 400 mg/kg/bw due to neurogenesis and amilioration can effective in memory recovery and neural necrosis in MS disease.