جستجوی مقالات مرتبط با کلیدواژه « التهاب مزمن » در نشریات گروه « پزشکی »

Overweight and obesity are associated with increased inflammatory conditions and metabolic disorders. A therapeutic agent that can suppress metabolic and immune disorders may effectively ameliorate parallel abnormalities in obesity. The aim of this study was to evaluate the effect of combined training and caffeine supplementation on Toll-like receptor 2 (TLR2), TLR4, and dectin-1 in obese men.

In a semi-experimental trial, 44 obese men were purposefully and accessibly selected and randomly divided into four groups: 1) control, 2) combined training, 3) caffeine and 4) combined training -caffeine. Subjects received 6 mg of caffeine per kilogram of body weight daily for 12 weeks. The combined training program include circular resistance training (3 times with 14 repetitions at 50% of one maximum repetition and 30 seconds rest between each station) and aerobic exercise (70% maximum heart rate for 30 minutes) was performed 3 sessions per week for 12 weeks. The combined training program was performed for 12 weeks and 3 sessions per week. Data were analyzed with covariance analysis and Tukey post hoc test at the p<0.05.

The results showed that 12 weeks of combined training, caffeine and combined training - caffeine significantly reduced serum levels of TLR2, TLR4 and Dectin-1 (P=0.001). The reduce of serum levels of TLR2, TLR4 and Dectin-1 were significant in the combined training compared to caffeine group (P=0.001). the effect of interactive combined training with caffeine was more than supplementation and training alone.

According to the findings, it is suggested that combined training intervention with caffeine consumption be used in order to reduce its inflammatory effects associated with obesity.

Inflammatory pain is caused by tissue inflammation and injury. Formalin is one of most important compounds used to induce inflammation. At the moment, the recognition and development of anti-inflammatory drugs that are naturally occurring have been very much taken into consideration. Cuminum is one of plants with anti-inflammatory potentials. Considering the importance of a more complete understanding of the mechanisms that create and advance inflammation in order to find better, more complete and less complicated ways to improve inflammation and inflammatory pain, much and sometimes intense side effects of chemical treatments, The growing importance of medicinal plants in various medical fields and importance and diverse applications of Cuminum in medical sciences.

The purpose of this study was to evaluate the anti-inflammatory effect of Cuminum aqueous extract in male rats.

36 rats were used in different groups. Aqueous extract of Cuminum fruits was prepared at doses of 200, 500, 1000 mg / kg. Inflammation induced by subcutaneous injection of formalin in animal's foot and then, inflammatory pain was evaluated. One-way ANOVA was used to analyze the data.

Different doses of the extract reduced the acute and chronic inflammation. The highest reduction effect in the acute phase was related to dose of 200 mg/kg and in the chronic phase, the dose was 1000 mg/kg.

aqueous extract of the Cuminum plant has an acute and chronic anti-inflammatory effect, and this effect is dose-dependent.

Polycystic ovarian syndrome (PCOS) is a proinflammatory state that underpins the development of metabolic aberration and ovarian dysfunction in the disorder. Chronic inflammation and increased levels of androgens in these patients and their impact on the immune system, may be able to disrupt antitumor activity and thus increase the risk of developing malignancies including ovarian cancer.
Peripheral blood mononuclear cells of 50 patients with PCOS and healthy controls were purified by Ficoll density gradient centrifugation. We then measured cell proliferation and concentrations of cytokines TNF-α at different time intervals (48 and 72 hours) after co-culture of ovarian (SKOV3, A2780) and breast (MCF-7, MDA-468) tumor cell lines with PBMC in indirect contact of transwell system.
Proliferative response of executive cells during stimulation with tumor cell lines after 48 hours was not statistically significant between patients and healthy controls. Between the 2 groups, proliferation rates at the end of 72h were significantly higher than after 48h (P Our findings confirmed that, compared to healthy individuals low levels of chronic inflammation in patients with PCOS exhibit increased proliferative response of immune cells and TNF-α levels. An increased risk of cancers in patients with PCOS however requires investigation of other aspects of anti-tumor responses in vitro, with larger sample sizes.

Inflammation is as a beneficial response to injury on the other hand, inflammation is accounted as complex immune systems of the host against agents biologic, chemical and physical. Chronic inflammation that was produced by genetic mutations, autoimmune diseases and environments factors can increase risk of cancer. Epidemiologic studies have shown more than 25% of dead cause of cancer was inflammation. Although, today it is believed that inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury and that the basic signs of inflammation can be explained by pain, increased blood flow, red and swelling. Acute inflammation can be produced in which under normal conditions is considered as immune reaction, if it converted to chronic inflammation can be led to cancer, CVD, lung and nervous diseases. The aim of the present minireview was to examine the evidence about inflammation and its correlation with cancer.

Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of this study was to evaluate the association between these biomarkers among postmenopausal women. A total of 361 healthy Iranian postmenopausal women were randomly selected in a population-based study. The metabolic syndrome was defined according to NCEP, ATPIII criteria. Circulating hs-CRP and IGF-1 levels were measured by highly specific enzyme-linked immunosorbent assay method. Women with higher than median hs-CRP levels had lower IGF-1 levels, in comparison to women with lower than median hs-CRP levels (p<0.0001). In multiple regression analysis, after adjustment for age and the metabolic syndrome, IGF-1 levels had a significant inverse correlation with circulating hs-CRP levels (β=-0.139, p<0.007). After adjustment for age, body mass index and type 2 diabetes mellitus, IGF-1 levels also showed an inverse correlation with hs-CRP levels (β=-0.130, p<0.014). There is a significant inverse correlation between serum IGF-1 and hs-CRP levels in postmenopausal women. This finding provides evidence of the potential cardioprotective effect of IGF-1 via anti-inflammatory mechanisms.

Rheumatoid arthritis is a chronic inflammatory disorder of connective tissue that has affected 1% of human population. The role of calcium antagonists in acute inflammation has shown by previous studies. Therefore the aim of the present study was to investigate the effect of verapamil and nifedipine (two calcium antagonists) on experimental arthritis induced by complete Ferund’s adjuvant (CFA) in rat knee. This experimental study was carried out in 8 groups of adult male rats. In group 1 and 2 (CFA and control group), 0.2 ml of CFA or saline solution were injected respectively. Groups 3and 4 received 100 and 800µg/kg nifedipine and groups 5 and 6 received the same doses of verapamil orally 7 days after injection of CFA till the end of study. Group 7 (solvent group) received dimethyl sulfoxide (DMSO) as same as groups 5 and 6 and group 8 received 15mg/kg ibuprofen daily from day 7th orally with gastro-intestinal tube. The changes caused by chronic inflammation were evaluated by measurement the knee diameter and Evans blue (E.B) content through 28 through days of CFA injection. The finding of this study showed that on day 7th after CFA injection the knee diameter (13.1±0.2mm) increased significantly compared to the day zero (9.99±0.08 mm). The increasing of diameter was significant till the end of study (day 28) (p<0.001). DMSO failed to reduce the increased diameter induced by CFA but the high dose of nifedipine on day 14, 21 and 28 and its low dose only on day 28 reduced the increased diameter significantly (p<0.01). The low dose of verapamil on days 14 and 28 and its high dose only on day 28 have had an inhibitory effect. Ibuprofen inhibited the increased diameter during all 28 days of study significantly (p<0.01). The E.B content before the injection of CFA was 2.97±0.14 µg/100mg tissue that increased significantly after injection of CFA. Whereas 7 days after CFA injection, E.B content was 12.37±0.7µg/100mg tissue (p<0.001). Either low or high dose of calcium channel blockers had significant inhibitory effect on E.B content on days 14, 21 and 28 p<0.001. The inhibitory effect of calcium channel blockers on E.B content was comparable to ibuprofen effect on the day 28. The findings of this study showed that nifedipine and verapamil can inhibit the experimental arthritis induced by CFA injection into the rat knee, by reducing the knee diameter and decrease the E.B content (albumin leakage).

It has been shown that inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow, and the joint vascular? -Adrenoceptors are changed due to acute inflammation from a majority of? -1 to an equality of? -1 and? -2 receptors. To investigate the role of sympathetic nerves in nerve induced vasoconstriction and changes in joint vascular? -Adrenoceptors due to chronic inflammation, in 21 NZW rabbits, chronic inflammation of the knee joint was induced by antigen induced arthritis method. It experiment day animals were anesthetized and the caudal femoral artery, a branch of tibial artery, was connulated to inject the? -agonists intra-arterially close to the joint. Posterior articular nerve (PAN) was dissected free for electrical stimulation. Electrical stimulation of PAN resulted in 18.1±6.2% reduction of blood flow measured by laser Doppler flowmetry technique. Phentolamine completely blocked the constrictor response and reversed it to vasodilation (+8±2.2%). Propranolol (Non-selective? -Adrenoceptor antagonist) completely blocked this vasodilation response and reverse it to a vasoconstriction. Atenolol (?1-agonist) non-significantly reduced the dilator response but ICI 118551 (?2-antagonist) reduced 50% of this response. Close intra-arterial injection of different doses of? -agonists, isoprenaline (Non-selective? -agonist), dobutamine (?1-agonist) and salbutomale (?2-agonist) increased the joint blood flow by the potency rank order of “Isoprenaline>salbutomale>dobutamine”. The isoprenaline dose response curve was shifted to the right by? -Adrenoceptor antagonists by the potency rank order of propranolol>ICI>atenolol. Overall this study showed that? -Adrenoceptor response is stronger and suggested that the shift from? 1 to? 2-Adrenoceptor subtype started by acute inflammation continued in chronic inflammation and the sympathetic vasoconstrictor response was nearly recovered toward normal compared to acute inflammation.

Acute inflammation is the most common pathologic change in appendix and it has a well-recognized clinical presentation. However, in some patients, definite diagnosis and treatment may be delayed due to the atypical clinical course of the disease. Patients may present with chronic pain alone or chronic with acute attack of abdominal pain in right lower quadrant with or without other gastrointestinal symptoms. Chronic appendicitis may be a cause of chronic right lower quadrant (RLQ) abdominal pain and its prevalence has been a debated between surgeons and pathologists. This study was retrospectively performed on 1152 appendix specimens obtained following appendectomy due to acute appendicitis, in Ahwaz Imam Khomeini Hospital between 1998-2000. We evaluated the presence of pathological changes associated with chronic inflammation in the samples. We found that acute appendicitis was more prevalent in men (754 cases and 65.5%) than in women (398 cases and 34.5%). Pathologically 162 (14%) of cases had normal appendix, 30 (2.6%) were in early phase, 844 (73.3%) were in suppurative phase of appendicitis. On the other hand, 67 (5.8%), 32(2.8%), 17(1.5%) of cases were in gangrenous, perforation and chronic phases of appendicitis respectively.We concluded that although the chronic inflammation is less common pathologic change of appendix but this may explain some cases of chronic abdominal pain in right lower quadrant.

Calcium mobilization is known to be an important factor in the activation of cells involved in inflammation, so, calcium-channel antagonists are be expected to exhibit anti-inflammatory activity. In the present study, we evaluated the anti-inflammatory effects of two calcium channel blockers, verapamil an nifedipine on adjuvant induced chronic inflammation in rat paw. Sixty adult male rats were divided into 5 groups. Chronic paw edema was induced by intraplantar injection of 0.1ml of Freund’s complete adjuvant (FCA). Inflammatory edema measured in 0, 1, 2, 3, 4, 5, 6, 7, 14, 21 and 28 days after adjuvant inoculation. Verapamil (25 µg/kg), nifedipine (100 µg/kg), ibuprofen (12 mg/kg) with DMSO (Dimethyl sulphoxide) were given to animals daily through intragastric device from day 7 after adjuvant injection. Assessment of edema proformed by calculation of volume changes and by extravasation of Evans blue (E.B.) in the test groups compared to the control. FCA caused a remarkable increase in paw edema (0.8±0.05ml) after 28 days. Verapamil significantly reduced the paw edema (62.5%) at day 28. A marked inhibition was induced by nifedipine (50%) and ibuprofen (60%). No significant differences were found between inhibitory effects of ibuprofen and other drugs. Non of the drugs have any effect on the extravasation of E.B. These data suggest that calcium channel blockers, inhibit adjuvant induced chronic inflammation in rats and these effects are comparable to that of ibuprofen.

Introduction. One of the most common micro biol infect io ns in human be ings IS He lico bacter Pylori, T he infe cted people are mor e infected to such dis ease s the chro nic intlamation of the peptic ulcers a nd malignan cies of the digestive system, The aim of this re se arch is to study the infec ting patt ern in various age groups and determine the ra te of infe ction in Semnan (IJ'JJ), Materials and Methods. Cluster sampling was perfor med in th is st udy, Cluste rs/ho use ho lds were chose n systemat ica lly. one member of each hou sehold was chosen by cha nce a nd taken 3 rnl blood, T he serum was se pa rated fro m the blood a nd the n the level of antibody IgG in serum was measured by using E LISA meth od, Se rums more than 30 mR/ml ant ibody IgG considered as positive, Th e data were a na lyse d by Chi-Square test a nd P < O,OS was co nsidered as sign ificant. Results. T he resu lts indicate d that 4K% of the Se rnna n pop ulau on infected to He lico bacte r pylori, T his ra te be gun from the first to seventh decades. 22%, 3K%. 40%, 45%. 62%. 64% a nd 65%. respective ly a nd there was sign ificant association betwee n prevalence of He licobacter pylori a nd the peo ples age (P = O.OOOO) Conclusion. Findings indi cate by increasing the age, the infection increases too. As a resul t. most infec tion occ urred in the first. second a nd fifth decad es of lifet ime.