جستجوی مقالات مرتبط با کلیدواژه « ترومبوز وریدی مغز » در نشریات گروه « پزشکی »

Preeclampsia is a condition of placental pathogenesis, which divided into mild and severe forms, based on the severity of hypertension and proteinuria. Severe type of the disease with HELLP syndrome and neurological symptoms such as seizures play a very important role in maternal complications. Cerebral Venous Thrombosis with incidence of 11.6 per 100,000 deliveries per year,  as a rare cerebrovascular disease, can occur as a result of pregnancy-related changes in coagulation state and vascular endothelial damage and be the cause of the life-threatening risks of the preeclamptic mother.

The patient is a 22-year-old, gravida 1 (33 weeks) woman, with no history of underlying disease, who following the initial seizure and without consciousness, was transferred by the 115th Emergency Department to the triage unit of Valiasr Hospital in Kazerun. Due to repeated recurrent seizures during the 20-minute transmission and the results of test based on HELLP Syndrome, she immediately undergoing a cesarean section.  Subsequently, the results of the CAT-SCAN request confirmed the occurrence of cerebral venous thrombosis in the mother. The infant was discharged because of the absence of respiratory disorder and regularity of heart rate. Six-week postpartum follow-up showed maternal recovery.

Predisposition to cerebral venous thrombosis (CVT) also has a genetic basis and inherited thrombophilias constitute 22.4 % of the CVT cases. CVT with a varied clinical presentation and pathogenesis is one of the important causes of stroke which is not very common. Inherited thrombophilias with concomitant acquired risk factors like pregnancy may increase the risk of CVT manifold. Identification of a number of genetic variants increasing susceptibility to CVT and related traits opened up opportunity, to screening of women at high risk of developing obstetric CVT.

Cerebral vein thrombosis is a rare cerebrovascular disorder. Pregnancy and postpartum are associated with an increased risk of cerebral vein thrombosis due to hypercoagolopathy state. With regard to serious morbidity and mortality and the importance of pregnancy and postpartum period, special attention should be given to this disorder in this period. This study was performed with aim to determine the clinical signs and maternal and neonatal outcomes of cerebral vein thrombosis during pregnancy and postpartum period.

This retrospective study was performed on 30 women with cerebral vein thrombosis during pregnancy and postpartum period in Mashhad Ghaem Hospital from 2011-2016. Data collection tool was a researcher-made questionnaire. Demographic data, initial clinical symptoms, affected sinus, infarct and hemorrhage, and maternal and neonatal mortality were collected. Data were analyzed by SPSS software (version 16) and paired t-test. P < 0.5 was considered statistically significant.

Cerebral vein thrombosis was diagnosed in 13 women (43.3%) during pregnancy and in 17 (56.7%) during postpartum period. Primary manifestation in more than half of patients was headache (57.7%). The upper sagittal sinus was the most common (70%) and the right sigmoid sinus was the rarest involved sinus (16.6%). Among patients with cerebral vein thrombosis, 4 patients and one fetus died that all 4 patients had hemorrhagic infraction.

Considering the importance of pregnancy and postpartum period, rapid diagnosis and timely treatment of cerebral vein thrombosis, especially pay attention to the symptom of headache, is important to improve the prognosis.

Cerebral venous thrombosis (CVT) is a rare disorder. Incidence of CVT in developing countries is not clear. This study was conducted to determine the incidence rate of cerebral venous thrombosis, its symptoms and some of its predisposing factors in Kermanshah city. This was a descriptive study. The sample size included 21 cases. Diagnosis of cases of CVT was based on MRI sequences T1, T2, FLAIR and approved by the gold standard MR venography over 12 months. The data were introduced into SPSS software and analyzed by means of descriptive statistics and the frequency of data was calculated. This study included 21 patients; three males (14.3%) and 18 females (85.7%) with a mean age of 36.00±10.13 years who had a total number of 55 thromboses. The most prevalent clinical symptoms, predisposing factor, associated disorder, and sinus involved, included headache (95.2%), OCP consumption (52.4%), infarction (47.6%) and superior sagital sinus (71.4%) respectively. This study showed that the incidence of cerebral venous thrombosis in Kermanshah is relatively higher in comparison to the statistics mentioned in other studies, so further studies for more evaluation of contributing factors in this disease are recommended.

There is a tendency in Muslim women to postpone their menstrual period with short course oral contraceptive (OC) consumption during Ramadan as well as Hajj Ceremony. Driven by many anecdotal reports regarding stroke, particularly cerebral Vein thrombosis (CVT) in Ramadan, this research was designed to investigate the incidence of CVT and its temporal relation with Ramadan. This study was conducted between September 2006 and October 2007 and included 2 consecutive Ramadans. All patients with definite diagnosis of CVT in Ghaem Hospital of Mashhad were registered. We assessed all of the possible causes of CVT and analyzed the temporal aspect of CVT occurrence. 24 cases with CVT (5 males and 19 females) were recruited during study period. 11 cases were admitted during Ramadan months which was significantly higher than all the other 11 months (P value=0.00035, χ² = 17.1). There seems to be no underlying disorders for CVT in Ramadan except OC consumption. The higher incidences of CVT in Ramadan may be related to OC consumption. Although we could not identify any risk factors such as hypercoagulopathy state in these cases, it is still possible to implicate an unknown genetic background which can result in CVT in special scenarios such as OC consumption. We need to consider fasting situation, dehydration and physical stress in Ramadan as probable cofactors for CVT.