جستجوی مقالات مرتبط با کلیدواژه « ترکیبات فعال زیستی » در نشریات گروه « پزشکی »

Diet is an important environmental risk factor for breast cancer. Grapes are one of the most abundant fruits in the world; they are a valuable source of active metabolic compounds that control the proliferation and growth of breast cancer cells.

The present narrative review is based on Persian and English papers published between 1996 and 2022. The papers were retrieved via an internet search on PubMed, Google Scholar, Science Direct, and Scopus databases using the keywords “cancer,” “breast,” “bioactive metabolites,” “Vitis vinifera,” and “grapes.”

The findings of the investigations showed that the bioactive compounds of grapes, including resveratrol, terpenoids, oleanolic acid, catechins, proanthocyanidins, anthocyanins, anthocyanidins, carotenoids, and flavonols, have the capacity to reduce oxidative stress, inhibit DNA synthesis, stop the cell division cycle, induce apoptosis of cancer cells, interact with multiple signaling pathways involved in the creation or destruction of tumors. Because of these functions, these compounds are of specific interest in the prevention and treatment of breast cancer.

Antitumor activities of natural compounds found in grapes indicate their possible role in the treatment of breast cancer.

Microalgae are important components in the food chain of aquatic and terrestrial ecosystems, the number of which is increasing and being consumed as food or medicine. Microalgae and cyanobacteria are produced in controlled culture processes or removed from natural habitats and marketed as a complete food supplement worldwide.

For this paper review of the results and conclusions of investigated research articles concerned with the subject.

Cyanobacteria have a wide range of biologically active compounds that produce and are expected to be used in the food and pharmaceutical industries. Due to the active composition of cyanobacteria such as fatty acids, sterols, volatile compounds, stable isotopic compounds, carotenoids, polysaccharides, lectins, mycosporin-like amino acids, bioemulsifiers that are anti-virus and anti-inflammatory due to their elevation and etcetra are used for marketing purposes.

This review article attempts to introduce the active compounds of microalgae and their biological activities, their nutritional value in human diet and health, during different periods, aquatic and other animals if possible.

Sea cucumbers are one of the most echinoderms and from the class Holothuroidea. Some of their specific biological activities are including anti-cancer, anticoagulant, antihypertensive, anti-inflammatory, antimicrobial, antioxidant, anti-atherosclerosis and anti-tumor properties, as well as accelerate wound healing. The presence of different compounds such as saponins, chondroitin sulfates, glycosaminoglycans, sulfated Polysaccharides, glycoprotein, glycosphingolipids and essential and non essential fatty acids, are the causes of their biological properties. Saponins, which are produced for compatibility with the environment, are as theire secondary metabolites. These active compounds have biological properties like hemolytic, anti-tumor, anti-inflammatory, antibacterial, antiviral, ichthyotoxic, cytostatic, anti neogenic, antineoplastic, and uric acid lowering effects. Sea cucumber, have high economic value. In East Asia, Since ancient times, it have been traditionally used for the treatment of fatigue, sexual impotence, impotence caused by aging, constipation due to intestinal dryness, urinary incontinence, asthma, hypertension, arthritis and anemia. Also, toxins obtained from sea cucumber, have anti-viral, anti-tumor, anti-cancer and anti-pregnancy properties. According to literatures, the aqueous extract and high molecular weight compounds from sea cucumbers can inhibit tumor activity, via the apoptosis induction. Sea cucumbers because of the high percentage of protein and the absence of cholesterol, classified as an invigorating food. Because of different species of sea cucumbers in the Persian Gulf and Oman Sea; the identification of compounds and biological properties of sea cucumber species in these regions is recommended to the researchers.

Due to increasing prevalence of cancer, low efficiency or high toxicity of the current drug, novel cancer chemotherapy drugs are required. Natural bacterial products are among the richest sources of new compounds with different biological activity including anticancer properties. There are lots of commercialized naturally derived anticancer drug originated from actinomycetes. In the presented research, we aimed at mining Actinomycetes strains which are capable in production of potent anticancer compounds. Subjects and Forty indigenous Actinomycete strains were received and recovered from University of Tehran Microorganisms Collection (UTMC). Sporulation, seeding and fermentation of indigenous strains were carried out. Then, total produced secondary metabolites of each strain were investigated for their toxicity against eukaryotic cells on the model organism, Artemia franciscana. High (40-59%), medium (20-39%) and no toxicity effects were observed in 23, 16 and a single extract of the investigated strains, respectively. This study has shown that soil-dwelling Actinomycetes of Iran are a rich source of cytotoxic compounds with potentially anticancer activity. The introduced strains which produce potent cytotoxic compounds can be considered as reasonable candidates for further studies to find anticancer drugs.