جستجوی مقالات مرتبط با کلیدواژه « حفره ی دهان » در نشریات گروه « پزشکی »

Squamous cell carcinoma is one of the most common malignancies in the oral cavity. The number and distribution of mast cells affect the pathogenesis of oral squamous cell carcinoma (OSCC). Mast cells can produce enzymes, such as matrix metalloproteinase-9 (MMP-9) that can affect OSCC growth and the aggressive behavior of tumors. This study investigated the mast cell density and immunohistochemical expression of MMP9 in OSCC.

In this descriptive study, 10 paraffin blocks of OSCC were selected from the pathology department archive in the Dentistry College of Jundishapur University of Medical Sciences and Imam Khomeyni Hospital in Ahvaz, Iran. Afterward, 4-µm sections were cut from paraffin blocks and stained using the immunohistochemical method for MMP9 expression and using toluidine blue for mast cell count. The expression of MMP9 in the epithelium and connective tissue was investigated, and the number of mast cells was counted in five high-power fields.

In this study, MMP9 was expressed (over 50%) in eight cases in the epithelium and nine cases in connective tissue. In one case, MMP9 was not expressed in the epithelium. No statistically significant association was observed between immunohistochemical expression of MMP9 in connective tissue and the mean number of mast cells in OSCC connective tissue. One of the specimens was excluded from this study due to the low amount of tumor tissue.

Expression of MMP9 in the connective tissue of all cases may indicate the aggressive behavior of OSCC; however, this expression may not be related to mast cell density or may be suppressed with a high number of mast cells.

 Oral pyogenic granuloma (PG) is a benign lesion that can occur due to chronic mild irritation, a traumatic surgical procedure, hormonal changes, certain medications, after bone marrow grafting, a response to a graft, etc. Two histopathological type of PG are lobular and non-lobular. This aimed to assess and compare the clinical, microscopic, and etiologic factors in the two type of PG.

 In this cross-sectional descriptive/analytical study, 214 samples of PG were selected from the Archives of the Pathology Department, Isfahan Dental School. Demographic, clinical, and microscopic data were collected by reviewing the files and slides. Data were analyzed with SPSS 24, using descriptive statistics, chi-squared test, Mann-Whitney test, Fisher‘s exact test, and t-test (α = 0.05).

 There were 47 lobular cases, with 167 non-lobular samples. Lesion sizes (p value = 0.035), location of lesions (p value < 0.001), mean vascular density (p value < 0.001), concentration of large endothelial cells (p value < 0.001), edema (p value = 0.007), inflammatory infiltration intensity (p value < 0.001), and vascular canalization (p value = 0.005) were significantly different between the two groups.

 The present study showed that some parameters between the two microscopic types of pyogenic granuloma were different significantly, accounting for the clinicopathological differences between two groups; this warrants further studies.