جستجوی مقالات مرتبط با کلیدواژه « صبر زرد » در نشریات گروه « پزشکی »

This study investigated the effects of hydoalcoholic Aloe vera extract on fetal cerebellar tissue in diabetic pregnant rats.

Forty eight adult pregnant Wistar rats were divided into 6 groups of 8 including control(C), receiving 400mg/kg Aloe vera extract(CA), diabetic(D), diabetic receiving 20IU/kg insulin(DI), diabetic receiving 400mg/kg Aloe vera extract(DA) and diabetic receiving 20 IU/kg insulin and 400mg/kg Aloe vera extract(DAI). The rats received insulin subcutaneously and the Aloe vera extract through gavage. Blood glucose and body weight were recorded on days 1,7,14 and 18 of gestation. On day 18, the weight of each rat and the number and gender of its fetuses were recorded. Fetal brains were removed and tissue sections of their cerebellum were prepared. The results were analyzed through ANOVA and at the significant level of p≤0.05.

Blood glucose in diabetic groups was significantly higher than C and CA groups. Weight of pregnant rats on days 7,14, and 18 significantly decreased in the D,DI, and DAI compared to the C and CA groups. The number of newborns significantly decreased and the neonatal weight increased in all diabetic groups compared to the C and CA groups. Compared to the C group, the thickness and number of gray and white matter cell bodies and thickness and number of cells in the molecular layer,Purkinje and granular cells significantly decreased in the D group compared to the C group.

Aloe vera extract was able to prevent the effects of excessive production of oxidants in diabetes.

Cutaneous wounds are seriously painful and their antibiotic treatments are expensive with adverse effects. Nowadays medicinal herbs are widely used because of lower cost and side effects. Calendula officinalis, Aloe arborescens and Ricinus communis herbs have antimicrobial and healing effects. The aim of the present study was comparing the effect of these three herbal medicines on cutaneous wound healing process in male rat.
In this experimental study, 32 male adult rats were randomly divided into 4 equal groups of 8, including one control group (wound group and topical use of eucerine in the injured area) and three groups treated with Calendula officinalis, Aloe arborescens and Ricinus communis (topical use of 2cc extract 10%). Wounds with equal thickness were made on the rats’ back sides and their diameters were measured in the treatment period (21 days) and tissue samples were finally prepared. Data were analyzed by one-way ANOVA and Tukey's post hoc test.
Diameter measures of the wounds on the 5th day showed that the average of the wounds’ diameters in the Calendula officinalis and Ricinus communis treated groups were significantly lower than the control group (p Ricinus communis medicinal herb has more improving effect on cutaneous wound healing in rat.

Background and The use of herbs to treat disease is associated with human history. Aloe vera is one of the oldest medicinal plants from ancient times until today, has been used by humans. The first written report in which he is mentioned Aloe Vera belonging to four thousand years BC, and the plant since ancient times to treat diseases has gone to work. The aim of this study was to introduce this valuable plant is complete and comprehensive.
Methods and Materials: The study was conducted library research and literature on traditional medicine and modern plant names, history of traditional, physical description, distribution, various information necessary in utilization, ecological needs and the information necessary to evaluate its cultivation and were reported.
Indications and constituents of this plant is very extensive clinical studies, most of these effects has been proven and the most important anti-cancer properties, treatment of burns and digestive diseases.

Background and Sabr-e- Zard (Aloe Vera)plant is hot and dry and native to Africa and are grown at sout Iran. When the leaves are cut, Jelly of the plants placed outside has Specific pharmacological effect. First Egyptians were used this plant to treat wounds, burns and infections. From the 1930s onwards extensive scientific research on drugs and medicinal properties of the plant was done and gel filtration strange power of this plant to the treatment of wounds and burns approved. Aloe Vera in the world today is planted to treat a number of diseases of the digestive migraine to treat acne and burns. The knowledge that indigenous people have about their environment, especially plants is very precious so record and store the information that are rapidly disappearing, is necessary. The purpose of this study is evaluation of medicinal plants: Aloe plant as a medicinal plant of Qeshm Island.
Material and In this research, by using the methods of observation and interviews, many years of knowledge they had, were collected and a variety of plants information, including plant characteristics, local treatment and traditional usages.
The results showed Despite the expansion of medical knowledge is still used in traditional medicine. As is common due to favorable climatic conditions this plant grown in different regions and consumed.

Traditionally, the natural ingredients have been used for faster healing of wounds. In this study, the effects of topical application of propolis and aloe vera were studied on the healing of open skin wounds in male rats. 32 male Wistar rats (300 - 350 g) were randomly divided into control and 3 experimental groups. After anesthesia, under sterile conditions round full-thickness wound with a diameter of 2.5 cm were created above the thigh of animals. In experimental groups, treatment of wound was performed with usage of ointment containing approximately 1gram of propolis or aloe vera or both of them, two times per day and continued for 20 days. During this period, the rate of wound healing was assessed by measuring the levels of wound in all groups. Also at the last day, under deep anesthesia, 1 mL of urine samples were taken from the bladder of all animals and its hydroxyproline concentration were measured. Data were analyzed using SPSS software with ANOVA and Dunnett test. Wound healing percentage showed no significant difference between control and experimental groups on 2 to 9 days, but in the 10 to 20 days interval, the treatment groups showed significant differences compared to control(P<0.05). The hydroxyproline content significantly increased in the combined aloe vera and propolis group compared to control (P<0.01).Discussion & The topical use of aloe vera or propolis accelerates healing of full thickness skin wounds and their combination is more effective.

Aspergillus flavus is the most important fungus for production of Aflatoxin B1 (AFB1). This toxin can be entered in the body through feed chain and ultimately leads to intoxications. The aim of this study was to investigate the effects of thyme (Thymus vulgaris L.), milk thistle (Silybum marianum L.) and cape aloe (Aloe vera) essences on the growth of A. flavus and AFB1 production. In this experimental study, concentrations of 0, 100, 200, 300 and 400 ppm of the studied plants essences were used in 4 replications. The AFB1 and major components of each essence were measured by Thin Layer Chromatography (TLC) and Gas Chromatography– mass Spectrometry (GC-MS) method. A rich medium (Yeast Extract Sucrose) was used for measuring the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC). Carvacrol, silydianin, and glucomannan were the main constituents of the essential oil of thyme, milk thistle and cape aloe. The lowest yield of AFB1 production belonged to the concentration of 200 ppm in thyme essence (P=0.001). In contrast, the maximum yield of toxin was observed in the concentration of 100 ppm in cape aloe (P=0.013). However, MIC for thyme essence was 200 ppm and MFC of this essence was estimated 400 ppm. 300 and 400 ppm of thyme essences has the highest MIC and MFC on fungal colonies growth and AFB1 production. Thyme essence may be added to food to prevent fungal growth and aflatoxin production.

Diabetes mellitus affects the metabolism of carbohydrates, lipids, and proteins, which leads to the dysfunction of the central and peripheral nervous system. Reports suggest that Aloe Vera has anti-diabetic effects. Therefore, this study was carried out to determine the effect of hydro alcoholic extract of Aloe Vera on Sciatic nerve of the diabetic rats. 45 male Sprague-Dawley rats weighing 200-250 gram were randomly divided into three groups of 15 rats as control group, the experimental group1 (DM), and the experimental group 2(DM+ Aloe Vera). Diabetes in the experimental groups of one and two was induced by injection of 50mg/kg Streptozotcin. The control group and the experimental group two received 50mg/kg Aloe Vera by gavage for 12 and 16 weeks. Then, the animals were anesthetized and sciatic nerves were dissected and fixed. The tissue changes of the sciatic nerves were surveyed by histologic and histomorphometric studies. The data have been analyzed by using the SPSS software In diabetic rats, a significant decrease was seen in the mean diameter of the myelinated nerve fibers and myelin sheath thickness of the Sciatic nerve. Long-term treatment with Aloe Vera significantly prevented all these abnormalities in treated diabetic rats (P <0/05). Our findings showed that the hydro alcoholic extract of Aloe Vera as a potential therapeutic agent that can help prevent histomorphometric and histologic changes induced by diabetic peripheral neuropathy.

Use of non-chemical treatments (medicinal plants) is a novel approach in the treatment of diabetes. This study was conducted with the aim of determining the effect of combined hydroalcoholic extract of medicinal plants on the treatment of diabetes in normal and diabetic male rats and its comparison with the effect of glibenclamide. Thirty-six male rats were randomly divided into six groups: normal control (NC)، diabetic control (DC)، diabetic rats received the plant extract at a dose of 0. 2g/Kg (D0. 2) and 0. 4g/kg (D0. 4)، and normal rats received 0. 2g/kg plant extract (N0. 2). The induction of diabetes was performed by intraperitoneal injection of a single dose of 60mg/kg of streptozotocin. Glucose level and weight were measured after injection of streptozotocin and 4-week gavage، and the insulin level was measured only at the end of the 5th week. Data were analyzed using one-way ANOVA and Tukey’s test. The significance level was considered to be p<0. 05. The blood glucose level in D0. 2 group was significantly decreased (p<0. 005) from the third to fifth week، as compared to DC group. However، the decrease in D0. 4 group was only significantly observed during the last week of the study (p<0. 01). In the DG group، in comparison with the DC group، the glucose level decreased during the third (p<0. 005)، fourth and fifth weeks (p=0. 001). No changes were observed in the insulin level in groups treated with the extract (p>0. 05 DC vs. D0. 4، D0. 2)، but in DG group، a significant increase (p<0. 05) was observed، as compared with DC group. The studied combined extract of medicinal plants has hypoglycemic effects in diabetic rats، which this combination has better effect in lower doses، but the mechanism of these effects is accomplished through increasing insulin levels.

Aloe vera is used in traditional medicine to treat hypertension. The purpose of this study was to examine the effect of the aqueous extract of Aloe vera (compared to Na+ nitroprusside) on the contraction of the rat isolated thoracic aorta precontracted with 20 mM potassium chloride. In this study, 18 rings isolated from the thoracic aorta of 9 Wistar rats (250-300g) were divided into three groups. On the loaded tissue, a tension less than 2 g was applied which then was precontracted with potassium chloride (20mM) in organ bath containing the carbogen-Krebs solution. Changes in aorta contractility in response to cumulative application of vehicle (group I), extract (group II: 5-50 mg/ml) and Na+ Nitroprusside (group III: 0.0001-10 μM) were measured isometrically. The results showed that although Aloe vera has a decreasing effect on the contraction induced by potassium chloride (20mM), this effect was less than the cumulative effect of Na+ nitroprusside (P<0.05). The possible antihypertensive mechanism of Aloe vera may be for reducing the contractility of vascular smooth muscle and this effect is weaker than the effect of nitroprusside. Hence, Aloe vera can be used as a potential drug for lowering the high blood pressure.

Aloe vera (Aloe barbadensis) and Teucrium (Teucrium polium) are used in traditional medicine as anti-diabetic herbs. The present study examined the effects of TP and aloe vera extracts on some metabolites like glucose، total cholesterol، LDL، HDL، VLDL and triglycerides in streptozotocin-induced diabetic Wistar rats. In this experimental research، forty rats were randomly divided into five equal groups. Trials in the study included the control group، diabetics (50 mg/kg STZ)، diabetics+extract of Aloe vera (300mg/kg)، diabetics+Teucrium (300mg/kg)، and diabetics+glibenclamide (5mg/kg). All solutions were given orally for 14 days. Blood samples of the rats were derived from their hearts on the 15th day of the experiment and their serum was isolated. Blood glucose in diabetic rats significantly reduced by aloe vera and Teucrium extracts (P≤0. 05). It was found that concentration of total cholesterol، HDL، VLDL and triglycerides in rats receiving Aloe vera and Teucrium extracts and glibenclamide was significantly lower than diabetic rats (P≤0. 05). Aloe vera and Teucrium were more effective than glibenclamide in reducing blood cholesterol levels. Compared with Aloe vera and glibenclamidettreatment with Teucrium had less effect on serum triglycerides. Serum insulin levels in diabetic animals receiving the herbs extracts significantly increased in comparison with diabetic rats. The use of Aloe vera and Teucrium extracts improve insulin secretion and reduce blood glucose and LDL

The pain resulting from episiotomy affects mother’s quality of life. Aloe vera and Calendula persica have been used for a long time to cure different diseases. The purpose of this study was to investigate the effect of Aloe vera and Calendula ointments on episiotomy incision’s pain intensity compared with that of hospital routine care (Betadine). This clinical trial was conducted from October to December, 2010 in Lolagar hospital in Tehran, Iran. 111 primiparous women, referred to the hospital for normal delivery, who were episiotomized, were selected using random allocation sampling method. After obtaining informed written consent and explaining the privacy of the research, subjects were assigned to one of the three groups of those who used Aloe vera ointment, those who used Calendula ointment and control group, before delivery. The data collection instrument was a questionnaire which included personal profile, demographic factors, and midwifery and neonatal factors. Data was analyzed using SPSS software 16 and ANOVA and chi-square tests. Mean pain intensity before intervention (p=0.850), four hours after intervention (p=0.622) and 8 hours after intervention (p= 0.107) did not reveal any significant difference in three groups. Mean pain intensity, five days after the episiotomy showed a significant difference. There was a significant difference between the number of sedatives taken in third, fourth and fifth days after delivery among three groups. Using Aloe vera and Calendula persica ointment significantly reduces the intensity of the pain resulting from episiotomy and the need to sedative.

Testis is an important organ of the male reproductive system and its structure could be influenced by diabetes. Aloe Vera has a hypoglycemic effect; thus, the present study evaluates the effect of Aloe Vera on the testis tissue of a 20-day embryo of rat born from a diabetic mother. Thirty female Sprague Dawley rats were randomly divided into three groups, subsequently; two groups were injected with streptozotocin (50 mg/kg/IP) and the males were placed next to female rats in a separate cage in order to mate. One group of rats received aloe vera extract (400 mg/kg), orally, in gestational age during while others were giving distilled water. After 20 days, rats were sacrificed and their embryos were removed and fixed by 10% formalin. The embryos were processed and embeded in paraffin. Five µm sections were made and stained by hematoxyline- eosin and cellular alteration of testis was evaluated. Data were analyzed using one-way ANOVA. Mean of body weight, seminiferous tubules diameter, spermatogonia numbers, leydig cells and sertoli cells were significantly different in all groups (p<0.05). The present study demonstrated that Aloe Vera extract can increase the spermatogonium, Leydig and Sertoli cells in diabetic rats.

Aloe vera is native to North Africa, and is also cultivated in Turkey. Aloe has long been used all over the world for its various medicinal properties. The aim of this study was to measure the interaction effect of Aloe vera and glibenclamid on blood glucose, LFT and lipid metabolism in streptozotocine-induced diabetic male rats. This experimental study was carried out on 40 wistar Albino male rats in Zahedan University of Medical Sciences. Animals were divided into five groups, one as control (intact), and the others as experimental groups. Rats in the experimental groups were made diabetic by streptozotocin injection (65mg/kg-IP). The diabetic groups, except one (diabetic control), received 400 mg/kg aloe vera extract, 5mg/kg glibenclamid and 400 mg/kg Aloe vera extract with 5 mg/kg glibenclamid daily for 4 weeks by gavages respectively. At the end of experiement fasting blood samples were collected from all groups. The results showed that FBS, TG, Ch, AST, ALT levels in the experimental groups were significantly decreased in comparison with those in the control group (p<0.05). There was no significant difference on HDL level. In addition, Alk.P level in glibenclamid alone and glibenclamid + Aloe vera groups were significantly increased in comparison with the control group (p<0.05). The results of this research indicate that interaction of Aloe vera aqueous extract and glibenclamid decrease blood glucose, TG, Ch, LDL, AST and ALT levels. However, the effect of Aloe vera extract in combination was not greater than the effect of Aloe vera extract alone. These findings may be due to the effects of Aloe vera and glibenclamid on glucose metabolism. Further research is suggested to study the exact mechanism of them in diabetic rats.

Background and While aloe vera has the capability of reducing libido regulating menstruation and being widely used there is scarce information on the effect of its alcoholic extract on the functions of pituitary-gonad axis. Therefore the present study aims at investigating the effect of Aloe vera alcoholic extract on spermatogenesis in male rat. Methods and Materials: In this experimental; study 45 male Wistar rats were divided in to five groups including 1 control 1 sham and three experimental groups. Each rat in the experimental groups was treated orally with 50 100 and 150 (mg/kg) doses of Aloe vera alcoholic extract for twenty one days after the extract was prepared via percolation. The sham group received distilled water and alcohol; while control rats received nothing. After twenty one days blood samples were taken from each group directly from ventricles. Blood samples were used to measure the concentration changes of LH FSH and testosterone hormones. Obtained data were statistically analyzed using Tukey test and LSD. Concentrations of FSH in the average and maximum experimental groups (2.963.51 and 2.154.85 respectively) significantly reduced in comparison with the control group (3.112.16). Also concentrations of testosterone in the average and maximum experimental groups (6.183.41 and 3.925.27 respectively) significantly reduced in comparison with the control group (6.857.19). However no significant changes were observed in the concentrations of LH across experimental and control groups. Based on the results Aloe vera extract probably has anti-gonadotropin and antiandrogenic characteristics because of beta-sitosterol ascorbic acid P-coumaric acid coumarin and aloe emodin. It can cause disorders in the secretion of gonadotropin hormone (FSH) and testosterone.

Aloe barbadensis Miller plant was used for treatment of wound healing in traditional medicine. However it has different and sometimes contradictory effects. In this study the effect of Aloe barbadensis Miller gel on skin incisional wound healing in Rat was investigated. In this experimental study, forty male wistar Rats were randomly divided into 4 experimental groups including: sham operated, control and two treatment groups. Under deep anesthesia, an incision (3cm, full thickness) was made over skin of the back in Rats. The animals of sham group received no treatment. Control group received topical cold cream twice per day (from beginning to end of experiment) and treatment group's similarliy received topical Aloe barbadensis Miller gel mixed with cold cream (25% and 75%). For computing the percent of wound healing, the area of wound measured at the days 2, 4, 6, 8, 10, 12, 14 and 16 after beginning of experiments. Aloe barbadensis Miller gel at concentration 25% and 75% significantly improved wound healing at 12th day and 8, 10 and 12th days, respectively in comparison with control group. This study indicated that local administration of Aloe barbadensis Miller gel, accelerate the skin incisional wound healing in Rat. This healing is related to the gel concentration.

Contact Dermatitis (C.D) is a common condition and 5.4% of population are suffering from it. Main treatments are based on emollients and corticosteroids and in C.D cellular infiltration are mononuclears chiefly T. helper lymphocytes. The aim of this study was to have a new approach to herbals with new science covering and study the efficacy of alcoholic extracts of 4 herbals: henna, camomile cedar and aloevera in experimental C.D on mice. In a pilot experimental study first we chose 70 mice (ENMARY race, 50±10gr weight as case group, then we shaved behind of their left ears (at the days 0 and 1) and rubbed DNCB 400 mg/ml on the skin.At the 10th and 14th day the same amount of DNCB again was rubbed on the left ear. On the right ear the same amount of olive oil in Acetone dissolver was rubbed,as control group. Then at the times of 2, 10, 24, 48, 72, 96, 120, 150 hrs after the 2nd contact, the mice were killed with Ether, cutting the ears from base and prepared pathological sections for study of cellular infiltration. In second stage alcoholic extracts of 4 plants were prepared, then herbal cream with 4% concentration in cold cream as pallish cream were made, with considering the results of first stage that showed the maximal infiltration was at 120 hr after contact, the creams were rubbed every 12hr for 7 days on 40 mice in 4 groups that had been sensitized before with DNCB. 2 groups (20 mice) were considered as control (10 mice received no drugs and 10 mice received cold cream). 60 mice were chosen in the second phase and in general 130 mice were investigated. lymphocytic infiltration reduced after 7 days application of drugs for camomile group about 66/7%, cedar 50%, alaevera 12/5% and henna 0% Camomile chammazolen, Inositol had the best response (66/7% severe response) on improvement of contact dermatitis (P=0.02).

Aloe vera is a herbal plant being used as an anti-inflammatory agent, burning recovery as well as immune system boosting agent. The aim of this study was to evaluate the effects of Aloe vera on blood glucose, lipids and lipoproteins in streptozotocin-induced diabetic male rats. This study was carried out on 56 male rats, weighing 150-200 gr. Animals are divided into 7 groups (one control and six test groups). Diabetes were induced in test groups via streptozocin (65mg/ kg-IP). After a week, blood samples analyses for FBS. All diabetic groups, except the control one, were taken 100,200,300,400 mg/kg Aloe vera extract and 5mg/kg glibenclamid by gavages for a period of 4 weeks, respectively. After this period fasting blood samples were collected from all groups.The results showed that the FBS decreased in groups that received 400mg/kg and glibenclamid (respectively,162/62±23.12and193.37±26.51). In addition, 3-6 groups showed decrease TG and Cholesterol level in comparison with those of control groups. In all groups which received Aloe vera and glibenclamid, LDL level were significantly decreased in comparison with control groups but HDL level had no change. The results of this research indicate that Aloe vera aqueous extract lead to decreased Blood glucose, Cholesterol, LDL and TG levels. Further studies is suggested for exact mechanism of Aloe vera in diabetic rats.