جستجوی مقالات مرتبط با کلیدواژه « عصاره بابونه » در نشریات گروه « پزشکی »

Escherichia coli is a gram negative bacilli and the most common cause of urinary tract infection especially in patients admitted to the hospital, the elderly and pregnant women. Nowadays, the excessive use of antibiotics has led to an ever-increasing prevalence of drug-resistant strains, and it seems that the spread of these strains is much faster than the discovery of new drugs. Medicinal herbs are a rich and valuable source of various compounds with antimicrobial properties and can be a good option for solving the problems of using antibiotics. The purpose of this study was to investigate the inhibitory effects of aqueous and alcoholic extracts of chamomile, thyme, fennel and eucalyptus on some pathogenic factors of Escherichia coli causative agent of urinary tract infection.
In this study, the Escherichia coli bacterium was isolated from the urine specimen of patients with urinary tract infection and identified by biochemical methods. The effect of different dilutions of plant extracts on motility, hemolysin production and biofilm formation was investigated. MIC and MBC of extracts were investigated using disc diffusion method.
The results showed that, the alcoholic extract of thyme in three concentrations of 10, 5 and 2.5 mg/ml can prevent motility of the studied strain. Among the four plants studied, the alcoholic and aqueous extracts of thyme had the most effect in inhibiting the formation of biofilm. Alcoholic extract of thyme at concentration of 218.75 µg/ml and the alcoholic eucalyptus Extract at Concentration of 54.6875 µg/ml had inhibitory effects on the growth of bacterium, also the thyme alcoholic extract at concentration of 3500 μg / ml had bactericidal effect. None of the extracts had an effect on hemolysin production.
Considering the inhibitory effect of thyme and eucalyptus alcoholic extracts on bacterial growth and the ability of these extracts to prevent biofilm formation and bacterial motility, these two herbs can be considered as the first choice for the treatment of urinary tract infections.

Fungal Oral diseases affect the majority of the population and can affect a person’s overall health. It is reported that chamomile extract contain phytomedicine capabale of suppressing oral pathogens associated with fungal diseases. The aim of this study is the assessement of chamomile extract antifungal activity on Candida albicans.
The reference strain of C. A ATCC 10231 used for this study. The70% ethanol extract of chamomile was and then made in 2-512 mg/ml concentrations. The antifungal activity of the extract was examined by determining Minimum Inhibitory Concentration (MIC) and Minimam Fungicidal Concentration (MFC) using the macro broth dilution technique and agar well diffusion method.
Results showed that the ethanol extract of Chamomile had inhibitory and fungicidal effect only in concentration of 512 mg/ml.
Comparison of the results of ethanol control group and test group showed that inhibitory and fungicidal effect of hydroalcoholic extract of chamomile is due to 70% Ethanol but not the chamomile and Ethanol extracts of chamomile has no antifungal effect on Candida albicans.

Sleep disorder is one of the most common problems in menopausal women. Therefore, this study was performed with aim to determine the effect of chamomile extract on sleep disorder in menopausal women.
This double blind clinical trial study was conducted on 110 menopausal women aged 50-60 years who referred to health clinics of Arak and met the inclusion criteria. The subjects after convenience sampling were randomly included to one of the intervention or control groups. The intervention group received Chamomile capsule containing 400 mg of Chamomile extract twice a day for one month and control group received no intervention. At the end of the intervention, Pittsburgh Sleep Quality Index was again completed by the subjects. Data were analyzed by SPSS software (version 18) and Chi-square, paired t and independent t -tests.
The mean sleep quality score in the intervetion group before taking the drug was 13.68± 1.68 that changed to 9.07±1.53 after the intervention. Also the mean of this index in the control group was 12.98±2.50 before the intervention and 11.72±2.45 after the intervention. There was significant difference between the mean of sleep quality score in the intervention group before and after the intervention (P=0.001), but it was not significantly different in the control group (P=0.149). Also, there was significant difference between mean score of sleep quality in intervention and control groups after the intervention (P=0.001).
Using Chamomile extract is effective in reducing sleep disorder of menopausal women.

Angiogenesis is associated with tumor growth and metastasis of tumor cells, this processes directly linked with the production of nitric oxide. In this study anticancer effects of hydroalcohoic extract of M. chamomilla and avastin (bevacizumab) were investigated via dimethyl thiazol diphenyltetrazolium bromide (MTT) cell viability assay and nitric oxide (NO) production level in colon cancer cell line (HT-29).
In the present experimental study, the HT-29 cell line was cultured in RPMI-1640 media supplemented with 10% (v/v) fetal bovine serum (FBS), 1% antibiotic solution (consisting of100 U/mL penicillin and 100 µg/ml streptomycin). After growing to a favorite confluent, 104cells were seeded into separate 96-well culture microtiter plates and incubated at 370C in an incubator with 5% CO2 for 24 h prior to treatment. Every plate was treated with different concentrations of the extract (1000, 1400, 1800, 2200, 2600 µg/ml of medium) and bevacizumab (100,200,300 µg/ml). The production of NO was assessed by Griess reagent and the cell viability was determined by MTT assay. The results were compared by one-way ANOVA followed by Tukey-Kramer.
The results of MTT assay indicated that the extract and bevacizumab anticancer effect is time and dose dependent. The highest percentage of cell death was observed after 48 h incubation which increased in the bevacizumab concentration (P The results of the present study demonstrated that bevacizumab and the hydroalcohoic extract of M. chamomilla had an inhibitory effect on NO production by HT-29. The production of NO by HT-29 was inhibited after treatment by the extract of M. chamomillamay contribute to angiogenesis via decreasing of NO production and has antimatastatic effect.

Elderly people often suffer from sleep disorders. Chamomile due to the many health benefits such as sedation may be effective in improving sleep quality in elderly people. This study aimed to determine the effect of Matricaria chamomilla extract on sleep quality in elderly people admitted to nursing homes of Isfahan in 2014. The present study is a quasi-experimental clinical trial. The study population was 77 cases of elderly hospitalized in nursing homes. Participants were selected through random continuous sampling and divided into intervention and control groups. The intervention group received 400 mg oral capsules of chamomile twice daily after lunch and after dinner for 4 weeks. The control group did not receive the intervention. Sleep quality in older adults before and after intervention, were compared using the Sleep Quality Questionnaire Index (PSQI). Data's were analyzed using descriptive statistics and paired t and independent t tests. Before intervention, the mean score of sleep quality both experimental and control groups showed no significant difference (P>0.05). After intervention, the mean score of sleep quality was a significant difference between experimental and control groups (P<0.001). Oral administration of chamomile extract has sedative properties in sleep quality of hospitalized elderly patients in nursing homes. Therefore, it can be used in similar cases and nursing care.

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction. Presently, little is known about the primary factors that initiate PCOS. Chamomile flowers are used in alternative medicine for its anti-spasmolytic and anti-inflammatory effects. Antispasmodic properties of chamomile ease menstrual cramps and lessen the possibility of premature labor. This medicinal herb also stimulates menstruation. In this study, we evaluated the effects of Chamomile alcoholic-extract on the biochemical and clinical parameters in a rat model of PCOS. Estrous cyclicity of 30 virgin adult cycling rats was monitored by vaginal smears obtained between 0800 and 1200 hours. After about 4 days, each rat received an i.m. injection of Estradiol Valerate (Aburaihan Co., Iran), 2 mg in 0.2 ml of corn oil, to induce PCO. Corn oil was injected to the rats in the control group. All the rats in the experimental group were evaluated for follicular cysts 60 days after the injection. Rats with PCOS were treated by multiple doses (25, 50, 75 mg/kg) of intraperitoneal injections of Chamomile alcoholic-extract for ten days. The data were statistically analyzed at a significance level of p < 0.05 by ANOVA, followed by the Student Newman-Keuls post hoc test. The histological and hormonal results showed that Chamomile can decrease the signs of PCOS in the ovarian tissue and help LH secretion in rats (p < 0.05). The alcoholic-extract of dried Matricaria chamomilla L. flowers can not only induce recovery from a PCO induced state in rats, but also increase dominant follicles. Additionally better endometrial tissue arrangements can be regarded as another therapeutic effect of Chamomile.