جستجوی مقالات مرتبط با کلیدواژه « عصاره زنجبیل » در نشریات گروه « پزشکی »

Cadmium, a heavy and toxic metal, is a known environmental pollutant with teratogenic effects. This study aims to assess the influence of a course of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats.

In this experimental study, 48 12-week-old adult male Wistar rats, weighing 250 ± 30 grams, were divided into six equal groups: healthy control, exercise, cadmium (Cd), exercise-Cd, ginger-50 Cd, and ginger-100 Cd. The rats received 3 mg of cadmium chloride and hydroalcoholic extract of ginger at a rate of 50 or 100 mg/kg of body weight. The training protocol included running on a treadmill with an intensity of 27 m/min. After a 5-week period, the rats were anesthetized with diethyl ether, and their testis tissue was evaluated to determine the quantity of FGF-1 and VEGF.

The aerobic training group showed a significant increase (P=0.004) in the expression of VEGF and FGF-2 genes in testicular tissue compared to the control group. Conversely, the cadmium group displayed a significant decrease (P=0.001) in the expression of these genes. The ginger 100 and 50 + cadmium group did not show a significant change in VEGF and FGF-2 gene expression compared to the control group.

Cadmium exposure resulted in decreased VEGF and FGF-2 gene expression in testicular tissue, while exercise led to an increase. Additionally, ginger consumption appears to mitigate cadmium-induced tissue damage, although it does not increase the expression of VEGF and FGF-2 genes.

In this study, the effects of aerobic exercises and encapsulated ginger extract (GE) into chitosan nanoparticles (CNPs) were investigated on atrial natriuretic peptide (ANP) gene expression and cardiac histopathology in rat models of myocardial infarction.

The 25 male rats were divided into five groups: Isop (85 mg/kg), Isop + CNPs, Isop + GE-CNPs, Isop + AE, and Isop + GE-CNPs + AE. The rats performed AE on a rodent treadmill five days per week for six weeks. GE-CNPs were gavaged to rats at a dose of 500 mg/kg for six weeks. After the end of the treatment period, the expression of ANP genes was carried outby Real-Time PCR.

Based on our findings, the highest amount of collagen deposition was in the heart tissue of patient groups and the patient group treated with chitosan nanoparticles (P<0.05). Besides, the results of real-time PCR showed that the changes in ANP gene expression were significant only in the groups treated with aerobic exercise and ginger extract (P<0.05).

Regular aerobic exercises with nano-drug supplements such as ginger extract encapsulated into CNPs can reduce cardiac fibrosis and regulate ANP gene expression.

Proliferate potential differentiate into different cell lineages and high self-renewal of Mesenchymal Stem Cells (MSCs); thus, they are ideal tools for regenerative medicine. However, a leading problem is an oxidative stress in the target tissue and the apoptosis of transplanted stem cells before tissue repair. The pretreatment of stem cells with antioxidants may make them resistant to oxidative stress. Ginger is the main medicinal plant with antioxidant properties. This study explored the antioxidant effects of ginger extract on bioavailability and oxidative stress-induced apoptosis in human adipose tissue-derived mesenchymal stem cells and rat bone marrow examined. 

In this study, human adipose tissue-derived mesenchymal stem cells and rat bone marrow were cultured in a DMEM medium with 20% FBS. The explored cells were incubated for 4 and 6 hours for pretreatment with different concentrations of ginger extract (50, 100, 200, & 400 mg/mL); then, they were treated with 200 μM H2O2 for 2 hours. Bioavailability was analyzed by ELISA reader using an MTS kit and apoptosis was analyzed by flow cytometry using an Annexin V-FITC/PI kit into the manufacturer’s protocol at both times. The obtained data were analyzed by Analysis of Variance (ANOVA) using SPSS. 

This study was approved by the Ethics Research Committee of Shahrekord Branch, Islamic Azad University (Code: IR.IAU.SHK.REC.1397.028).

 The MTS results indicated a dose- and time-dependent manner increase in the bioavailability of human adipose tissue-derived mesenchymal treated stem cells. Ginger extract treatment also dose- and time-dependently decreased the rate of apoptosis in rat bone marrow mesenchymal stem cells. 

 Ginger extract, by reducing the oxidative stress in mesenchymal stem cells, elevates their lifespan in the target tissue, and increases the efficiency of these cells in tissue regeneration.

The aim of this study was to evaluate the effect of six months’ resistance training and ginger extract on lipid profiles, body composition and selected liver enzymes in obese menopausal women.

In a semi-experimental trial, 48 obese menopause women were randomly and divided into 6 groups including control, ginger extract, resistance training and resistance training -ginger extract. resistance training was performed 3 sessions in a week, 30-60 minutes for 24 weeks. The subjects consumed ginger extract three times a day in 500 mg capsule for 6 months. 24 hours, 3 months and 6 months after the intervention in the 12-hour fasting condition, subjects from each group received blood samples and anthropometric characteristics. Data were analyzed by two-way ANOVA with repeated measures and Tukey post hoc test at the p<0.05.

Six months of resistance training was associated with a decrease in ALT (p=0.016) and AST (p=0.002) in postmenopausal women, but combined exercise-ginger supplementation was no significant effect on ALT and AST in postmenopausal women (P>0.05).

It seems to Longer Periods Regular resistance exercise compared with combined exercise-ginger supplementation have more health benefits for obese menopause women.

Loading the active ingredients of medicinal plants in lipid nanoparticles reduces the reaction of the active substance with the surrounding environment, such as water and oxygen, and reduces the intensity of transmission or evaporation to the external environment. In this study, intended to enhance efficacy of ginger extract, encapsulation in nanoliponiosome synthesized by thin-film hydration method were done and their antifungal effect on the growth of Aspergillus flavus and Aspergillus parasiticus were studied.

In this experimental laboratory study, derivation was done using Soxhlet extractor method. Antifungal activity of ginger extract was specific by disc diffusion and microplate dilution methods. The inhibitory effect of extract was investigated. Physiochemical characteristics and structural characterization of nanoparticle were evaluated from the perspective of in vitro efficiency, drug release, nanoparticle size, zeta potential, surface morphology and FTIR (Fourier-transform infrared spectroscopy), DLS (Dynamic light scattering) and finally SEM (Scanning electron microscope) spectra.

FTIR investigations showed ginger extract and nanoliponiosome had no chemical interaction leading to change the functional groups. SEM microscope showed the spherical mprphology of particles and average particles size of 73nm. Ginger extract was loaded into the nanoliponiosome with a yield of 71%. It was also found out that ginger extract had a stronger antifungal effect against Aspergillus flavus fungus compared to the Aspergillus parasiticus fungus. At both 37°C and 42°C, the release of ginger extract was higher at pH of 4.5 compared to neutral pH (7.4).

Nanoliponiosomes containing ginger extract with good physicochemical properties, increased drug stability and good release control can be promising antifungal agents with high antifungal effects and low side effects.

Ginger is a plant that is used as a drug for pain relieving and anti-inflammatory in traditional medicine, but conventional prescribing of it faces serious challenges. One way to overcome these problems is the loading of ginger extract in polymer carriers. The aim of this study was characterization and evaluation of the loading and releasing of ginger extract from hyaluronic acid nanocapsules for medical applications.

In this applied study, ginger extract as a pain-relieving drug was loaded in hyaluronic acid nanocapsules. The hyaluronic acid nanocapsules containing ginger extract were fabricated by emulsion method. The surface morphology, particle size and zeta potential, surface roughness and functional groups on the sample surface were evaluated by field emission electron microscopy (FESEM), dynamic light scattering (DLS), atomic force microscopy (AFM) and fourier transform infrared spectroscopy (FTIR), respectively. The stability and ginger release from nanocapsules were also determined via DLS and HPLC, respectively. The toxicity and fibroblast cells viability of ginger extract encapsulated in hyaluronic acid were evaluated by MTT assay. Data were analyzed by SPSS 16 Software. The t-Student test was performed for statistical comparison of data and statistically significant was P < 0.05.

The ginger entrapment efficiency (EE %) in nanocapsules was 74%.  The average particle diameter and charge surface of the samples were calculated 413 nm and -10 mV, respectively. The negative charge of samples showed the stability of samples without agglomeration. Therefore, the surface morphology of the samples was observed as relatively spherical particles. In vitro test showed 95% fibroblast cell growth and proliferation on nanocapsules compared to the control sample (P < 0.05).

The hyaluronic acid nanocapsules have a great potential for delivery of ginger extract in the area of pain and inflammation.

Radiation is an essential modality in the management of cancer therapy but its acute and chronic side effects on the normal organs limit the helpfulness of the radiotherapy. The aim of current study was to investigate the effect of dose dependent whole body radiation exposure on amount of 8-OHdG and total antioxidant capacity in the male Wistar rat's plasma. It was also planned to elucidate whether ginger extract rescue the deleterious effects of different doses of radiation in rat kidney.
Male Wistar rats were exposed to three doses (2, 4, and 8Gy) of γ- ray with or without 10 days pretreatment of ginger extract.
After 10 days of whole body γ- ray exposure, the results revealed significant increases of 8-OHdG and significantly decreases of total antioxidant capacity in radiation groups (4Gy and 8Gy) compared to the control groups. It was no significant differences among ginger extract pretreatment groups and control group.
These findings indicate that whole body exposure to radiation induces kidney damage by oxidative DNA damage, and that these effects can be alleviated using ginger pretreatment as an antioxidant and anti-inflammatory agent.

The anti-inflammatory effects of the vitamin D and ginger have been demonstrated in some studies. The aim of this study was to evaluate the effects of vitamin D and ginger extract on the clinical symptoms and leukocyte infiltration of experimental autoimmune encephalomyelitis (EAE). For the induction of EAE, the (C57BL/6) were immunized subcutaneously MOG peptide emulsified in complete Freund's adjuvant. The mice divided into EAE group includimg: vitamin D-treated, ginger extract-treated, olive oil and phosphate-buffered saline, and also one group which was considered as normal group and received only PBS(phosphat- Buffered Saline). The mice were sacrificed at day 31 after immunization and the leukocytes infiltration was evaluated in the CNS (central nervous system). The EAE scores and the body weight were evaluated till day 30. Data were analyzed using t-test. Two control groups showed the clinical symptoms at day 10, whereas vitamin D and ginger-treated groups exhibited the symptoms at days 13 and 15, respectively. The maximum mean score of disease was (1.87±1.61), (1.92±1.79), (1.05±1.01), and (0.73±0.81) for olive oil-, PBS-, vitamin D3-, and ginger-treated groups, respectively. Vitamin D3 and ginger extract increased the body weight significantly)P =0.05) as compared to control groups. The leukocytes infiltration was also significantly lower in treated groups as compared to control group. These observations represent that the vitamin D3 and ginger extract have significant capability to attenuate the EAE severity.

Delayed gastric emptying among mechanically ventilated patients is common. According to evidence ginger can be accelerated gastric emptying. This study conducted to determine the effect of a ginger extract on gastric residual volume of patients hospitalized in Intensive Care Unit (ICU). This study was a double-blind randomized control clinical trial with before and after design. Twenty-four mechanically ventilated patients who hospitalized in ICU were enrolled into intervention and control groups (12 in each group). Patients were matched in items of gender and illness severity. After 48 hours gavage feeding with a standard solution among two groups; intervention and control groups respectively received 120 mg (5ml) of ginger extract and 5 ml of water as a placebo for 4 days. Residual volumes of the fifth and sixth days were recorded. Data analysis was performed using independent t-test and paired t test also significance level was determined as 0. 05. Mean gastric residual volume in first 48 hours between both groups was not significantly different. But mean and standard deviation of mean residual volume of fifth and sixth days in intervention and control groups were respectively (81/16 ± 58/24) and (09/15 ± 33/108) whichaccording the independent t test, showed significant difference (p <0.0001). Results showed that ginger extract reduces gastric residual volume compared with placebo in mechanically ventilated patients who hospitalized in ICU.