جستجوی مقالات مرتبط با کلیدواژه « عوامل فیبرینولیتیک » در نشریات گروه « پزشکی »

Thrombolytic therapy, an appropriate treatment option, if primary angioplasty is not available for the treatment of these patients in the early hours after the onset of the symptoms. The aim of this study was to evaluate the safety and effectiveness of new tenecteplase (TNKase) drug vs. streptokinase in the treatment of ST elevation myocardial infarction (STEMI) patients in Iran.
A systematic review and meta-analysis that was conducted in Iran University of Medical Sciences in September 2017. We searched the MEDLINE, Cochrane Library (DARE-EED-HTA, Web of Science and EMBASE (1980 to March 2017) with number of strategies by the words “myocardial infarction, heart infarction, streptokinase, tenecteplase” in combination with other names of drugs and brands for clinical effectiveness. We hand searched US, European, and Iranian cardiovascular journals. Clinical trials and related observational studies in one of the Persian, English and Korean languages were included in this study. Two review authors independently assessed randomized controlled trials (RCTs) and non-RCT studies eligibility and quality, and extracted the data using data extraction form for interventions reviews. We cross-checked and resolved discrepancies by discussion to reach consensus. Finally, the data were entered to the Review Manager, Version 5.3 (The Nordic Cochrane Centre, Cochrane Collaboration, 2014, Copenhagen, Denmark), and then the Cochran-Mantel-Haenszel test (CMH) were used to analyzed the data. The I2 test has been used to calculate the Heterogeneity.
We included 4 observational studies. Observational study assessment by strengthening the reporting of observational studies in epidemiology (STROBE) checklist and quality was high described. All studies entered the final analysis after the quality assessment. All studies reported mortality. In the meta-analysis of mortality, three studies with a sample of 812 people entered. No difference was observed between tenecteplase and streptokinase in the risk of mortality (RR=0.45, CI 95%: 0.20-1.03, P=0.40), hypotension (RR=1.86, CI 95%: 0.53-6.49, P=0.33), bleeding (RR=1.40, CI 95%: 0.49-3.99, P=0.53), and no difference was observed in the ST Segment resolution >50% (P=0.81).
The results of this study showed that the effectiveness and safety of streptokinase are similar to the tenecteplase drug

Fibrinolysis and coagulation are two main components of homeostasis. There is conflicting information available regarding the effect of regular exercise, particularly aerobic training on these factors
The purpose of this study was the effect of 8 weeks of combined training (aerobic-resistance) on blood coagulation, fibrinolytics factors in adult men.
In this quasi-experimental study, 30 subjects of elderly men (age 64.95±3.54 years) were randomly divided into 2 groups: experimental (n=15) and control (n =15) group. Experimental group, participated in a program of combined training (3 days a week for 8 weeks). To compare changes inside and outside group of the body weight, body mass index and levels of fibrinogen, PT, PTT, platelet counts and D-dimer fibrinolytic agent dependent and independent t-test and SPSS statistical software (version 21) was used.
After 8 weeks of combined training (Aerobic-Resistance) of fibrinogen and platelets count were significantly decreased in experimental group when compared to control group (0/001, 0/023) concurrently increased PT, PTT and D-dimer fibrinolytic factor (0/038, 0/005, 0/001).
The results of the present study suggest that participation in combined activities can be very useful for prevention of threatening complications hemostatic system and the aging process and To maintain good health as proper exercise protocol used in these patients. It is recommended that new training protocols and a variety of others, especially at the elderly and vulnerable to be investigated.