جستجوی مقالات مرتبط با کلیدواژه « قلب و عروق » در نشریات گروه « پزشکی »

Objectives Alzheimer’s disease is the most common kind of dementia in the old age, and its incidence increases with age. Previous studies have shown that cytokines are proteins that play an important role in inflammation, and their level changes in inflammatory diseases. Since Alzheimer’s disease is an inflammatory disease, cytokines may influence the occurrence of this disease. IL16 is a cytokine whose role has been proved in many inflammatory diseases. This gene is one of the coding genes of cytokines of the inflammatory process. It may be responsible for inflammatory pathology seen around old age plaques in Alzheimer’s disease. It can also associate with the pathology of Alzheimer’s disease. Therefore, the aim of this study was to investigate the effects of 2 polymorphisms of gene IL16 (rs1131445 and rs4072111) on the risk of patients diagnosed with Alzheimer’s disease in the Iranian population.
Methods & Materials In this study, the intervention group consisted of 144 individuals who were diagnosed with Alzheimer’s disease by psychologists based on a clinical test (DSM-IV), and the control group included 173 healthy individuals with no psychological disorders. DNA was extracted by salting out technique. The PCR response was conducted (for replicating the mentioned pieces) for any polymorphism in optimized conditions by using designed primers. The product of PCR was first checked for the confirmation of accurate function of PCR using polyacrylamide gel electrophoresis (PAGE). Next, the PCR product was dissected by restriction fragment length polymorphism (RFLP) method with intended confining enzyme, and then the genotype of the samples was determined by PAGE. Individual genotypes were determined using the PCR-RFLP method. Statistical analyses were done using OpenEpi 2.3.1 and SPSS 11.5.
Results The study of allelic analysis between the control and intervention groups by considering the confidence interval (CI=90%) and significant level (0.05) for rs1131445 showed that the C allele had no significant association with Alzheimer’s disease (P=0.656). The TC genotype did not show any significant difference with TT genotype (P=0.614). However, the study of allelic analysis for rs4072111 polymorphism between 2 groups showed that the relationship of T allele with the disease is significant, and this allele has a protective role in creating the disease (P=0.008). In addition, TC genotype as a protective status showed a significant association with Alzheimer’s disease (P=0.007).
Conclusion The existence of polymorphism in some genes of the inflammatory pathway could make people susceptible to Alzheimer’s disease. The genetic changes in DNA sequence of gene IL16 could result in changes in cytokine product or its function. The association between rs4072111 and Alzheimer’s disease supports the presumptions and shows a probable role of this polymorphism in Alzheimer disease. Besides, the association between rs1131445 and Alzheimer disease cannot be proven due to the small number of samples (Power: 8.23%).

Nowadays, Cardiovascular diseases (CVD) are the most important cause of death in the world. Given the role of cardiac risk factors in the development of atherosclerosis in childhood, the present study was done to investigate the effect of “healthy heart education program.” on knowledge and attitude of junior1 students in Birjand during 2011. This pre-post quasi-experimental study was done on 395 first grade students of Birjand junior high schools. Multistage randomized sampling method was used. A self-designed questionnaire on the basis of the specified goals of the study was designed, after confirming its validity and reliability. The questionnaires were filled out in two stages, namely before and after interference. The obtained data was analyzed using SPSS. software (V:16) at the significant level of α=0.05. Mean age of students was 12.48±0.57 years and 181 (45.8%) were male. Mean score of knowledge on risk factors of CVD was 8.26±3.21 before the education and 9.31±3.77 after it (P<0.001). Mean of the students’ attitude also increased from 38±4.93 to 39.1±5.78 (P<0.001). The impact of education on awareness and attitudes of the students was confirmed. Thus, healthy heart education programs in schools, as an educational priority, should be focused on the part of officials and managers in health the education systems.

Scientific collaboration is a process in which two or more authors share their ideas, resources, and data to create a joint work. This research attempted to study co-authorship, being a kind of scientific collaboration, in Iranian cardiovascular articles in Web of Science during 2002-2011.

The present research is. The population of this descriptive-analytical research study constituted Iranian cardiovascular articles indexed in WoS during 2002-2011. Indicators such as Collaboration Index (CI), Degree of Collaboration (DC) and Collaboration Coefficient (CC) were calculated to measure level of collaboration.

Articles published in cardiovascular field showed an ascending trend especially since 2002. Three-authored articles were the most and personal articles were the least frequent ones. Scholars were shown to be more interested in national collaboration based on Nationalization Index and according to collaboration indicators, scientific collaboration of cardiovascular researchers is also increasing.

Year 2002 can be considered as the inception of growth in scientific activities in cardiovascular field. Considering the interdisciplinary nature of the field, the present more tendency to scientific collaboration is an advantage that can play a major role in causing drastic improvements.

The lack of paying attention to overlap between two databases cause purchase of duplicate resources waste of funds. This study examined overlap of articles in the field of cardiovascular which was indexed in Scopus and Web of science databases during years 2001 to 2010. In this study، at first، sub-headings in cardiovascular field from medical thesaurus (Mesh 2012) was extracted، then each keyword in the title of the articles in both databases were searched and articles retrieved. Then bibliographic information of these articles entered into Endnote X3 software and afterwards was arranged based on alphabetically title. As a result common articles between the two databases and unique articles to each database was determined. Using SPSS version 0. 1. 0. 8 the amount of relative and traditional overlaps was calculated between the two databases. Totally 45،680 articles were retrieved. There were 27،979 common titles، 14،875 articles belonged only to Scopus and 2826 articles belonged to Web of Science. Finally traditional overlap was 61/5%. Overlaps of Web of Science with Scopus 65/28% and Scopus with Web of Science were 65/28% and 90/82% repectively. The amount of relative overlap between the two databases as well as relative overlaps from Scopus with Web of Science is more than the relative overlaps from Web of science with Scopus. It means many articles that have been indexed in Scopus don’t exist in the Web of science.

Olive is one of rare plants that have special status in catechesis and Quran clearly nominated it frequently، our prophet and imams declared its usage. In addition، olive is one of folklore plants in Mediterranean coasts that is became a symbol of this site. During a research، it was marked that the rate of cardiovascular and cancers diseases in Mediterranean population is lower than other because of Mediterranean diet which is rich in utilizing olive and olive oil. In this review we imply to some varieties of olive، olive oil and its nutrients then clarify the mechanisms and molecular pathways of these nutrients on different diseases. Our aim is analysis the beneficial effects of Mediterranean diet on health and finds the assertion of Quran and Islamic training in olive usage.

Cardio vascular diseases (CVDS) are important cause of morbidity and mortality in world wide and constitutes a major public health problem in Iran. Due to increase of CVD in this contex، the bjective of this study was to describe the prevalence of cardiovascular risk factors amony gonabad urban population. In this cross sectional study، a total of 606 subjects; males (205) and females (401) were recruited based on random cluster sampling method. The mean age of the subjects was 39. 41 12. 56 years old. Biochemical test were taken and consist of Blood glucose، total cholesterol، triglyceride، LDL-C and HDL-C and anthropometric and blood pressure measurement were performed. The data were analyse through chi- square، anova and T test using spss software version 13. The present study revealed that the most prevalent cardiovascular risk factors in gonabad were high LDL-C (130) and tatal cholesterl (200). The prevalence of high blood pressure، obesity، and abdominal obesity، were 33. 1%،22. 4%،17. 8% respectively. According to findings، high blood pressure wase more prevalent in females (33. 1) than males (30. 6). Present survey showed that prevalence of high blood pressure and WHR were significantly higher (p=0. 001) in males than in females and low HDL-C level was significantly more prevalent in women. (p= 0. 004) Coclusion: The prevalence of risk factor in gonabad exeedingly high. The present study showed high LDL-C and total cholesterol were the most prevalent risk factor found in this region. Continued strengthening program for prevention and intervention on these risk factor are need to reduced the incidence CVD in this region.

Cirrhosis is a pathologically defined entity associated with a spectrumof characteristicmanifestations.The cardinal pathologic features reflect irreversible chronic injury of the hepatic parenchyma and include extensive fibrosis in association with the formation of regenerative nodules.Autonomic dysfunction is a frequent and important complication of cirrhosis. The risk of mortality in cirrhotic patients with autonomic dysfunction is higher than that in cirrhotic patientswithout this complication.This study aimed to determine the frequency of autonomic cardiovascular dysfunction in cirrhotic patients.Materials andThirty cirrhotic patientswho admitted to Shahid SadoughiHospital and thirty healthy persons (control group, matched age and sex) inYazd from Dec 2005 to July 2006 were studied. In both group individuals with renal failure, heart failure and diabetesmellituswere excluded.Drugs that influence the autonomic nervous system were discontinued for 24 hours and then, 3standard autonomic function tests were carried out. Results fromtwo group were collected in a questionnaire and analyzed statistically. Of 30 patients, 24 (80%) were men and 6 (20%) were women. The mean age was 51.9+19.4 years and the mean duration of cirrhosis was 3.8 ± 2.7 years. Twenty-six patients (86.7%) had autonomic neuropathy. Twenty-four out of these twenty-six patients (80%) had parasympathetic dysfunction and two (6.7%) had combined sympathetic and parasympathetic neuropathy. None of themshowed sympathetic dysfunction alone. Four patients (13.3%) didnt have autonomic neuropathy.Therewas significant correlation between the frequency of autonomic neuropathy and the severity of cirrhosis (p‹0.001). Significant correlationwas seen between the frequency of autonomic dysfunction and the duration of cirrhosis (p‹0.01).Therewas no significant correlation between age, sex and the frequency of dysfunction neuropathy (p=0.118 and p=0.16, respectively).To assess the correlation between the etiology of cirrhosis and the prevalence of dysfunction neuropathy, a further prospective study involving a larger number of patients is necessary. More severe and prolonged hepatic failure was associated withmore frequent autonomic neuropathy in patients with cirrhosis.

Homocysteine (Hcy), an intermediate form generated during the metabolism of methionine, is associated with cardiovascular diseases. There is little information available about serum concentration of Hcy in healthy Iranian population. In the present study, we assessed the reference range of serum Hcy level among inhabitants of the northern Persian Gulf. In the Persian Gulf Healthy Heart Study (PGHHS) which used a multistage, stratified, clustered sampling, we measured fasting serum Hcy level using enzyme immunoassay method with an accuracy limit of 1 µmol/ L. Confounding factors such as smoking, alcohol consumption, drugs and chronic diseases were eliminated. Reference range for homocysteine level was considered between 5 and 95 percentiles. A total of 886 participants (39.3% female, 60.7% male) were evaluated. Mean plasma Hcy level was 14.58 ± 7.29 µmol/ L and was higher in men than women. Reference range for Hcy level was 8.35-31.1 µmol/ L in males and 2.39-24.31 µmol/ L in females. There was no difference among age groups for serum Hcy level. The Hcy level in the northern Persian Gulf general population is high. Since high Hcy level has been shown as a risk factor of cardiovascular diseases in various studies, it is essential to study the reasons of this high level of Hcy in this region.

Homocysteine is a non essential amino acid which is derived from metabolism of the essential amino acid, metionin. It has been shown that an elevated serum homocysteine level in adults is associated with vascular diseases. In this study, we determined serum homocysteine level and its gender and age distribution in three cities of Bushehr, Genaveh and Deilam in the northern Persian Gulf. A total of 1699 inhabitants of the north region of the Persian Gulf were selected based on a multi stage stratified clustered sampling and a fasting blood sample was taken from them. We measured serum homocysteine level using enzyme immuno assay method with accuracy limit of 1 µmol/L. Hyperhomocyteinaemia was defined as homocysteine more than 14 µmol/L. Mean plasma homocysteine level was 14.63±7.08 µmol/L (17.72±6.63 µmol/L for men and 12.73±6.78 µmol/L for women). No correlation between homocysteine and age was found. The prevalence of hyperhomocysteinaemia was 51.2% (22.2% in male and 29% in female). The homocysteine level in the north region of the Persian Gulf general population is high. Further study is essential to reveal the reason of the high homocysteine serum level in the inhabitants of the northern Persian Gulf with emphasis on folic acid and vitamin B12 serum levels.

Urbanization, establishment of sedentary life style and unhealthy diet in association with environmental stress has led the cardiovascular risk factors to prevail in the metropolitan city of Tehran. Survey of lifestyle related cardiovascular risk factors is one of the priorities of Tehran university population laboratory in the 17th zone of Tehran. 1573 inhabitants of 17th zone of Tehran were recruited by one stage cluster random sampling according to the model of WHO MONICA project. 58.6% of men and 64% of women had BMI ≥ 25 kg/m2. 41.7% of men and 37.6% of women had hypertension. 8.9% of men and 12.2% of women had diabetes. 34.4% of men and 44.6% of women had total cholesterol ≥ 200 mg/dl. 34.1% of men and 32.6% of women had triglyceride ≥ 200 mg/dl. 34.7% of men and 4.2% of women were regular smokers. 21% of participants had positive family history of cardiovascular disorders. The prevalence of hypertension in this region is high, that of dyslipidemia relatively lower than the other studies performed in Iran. The prevalence of Diabetes and overweight /obesity is high and comparable to other Iranian studies. It seems that the population of this zone is at high risk for stroke and then coronary heart disease. This fact must be considered in the future interventional programs to control cardiovascular risk factors in the region.