جستجوی مقالات مرتبط با کلیدواژه « لنفادنوپاتی » در نشریات گروه « پزشکی »

One of the most important steps in the treatment of patients with mediastinal lymphadenopathy is the definitive diagnosis using tissue sampling of the intra-mediastinal lesion. Mediastinoscopy is one of the methods used for this purpose. In this regard, this study aims to investigate the role of mediastinoscopy in determining the cause of mediastinal lymphadenopathy in patients referred to Shahid Beheshti Hospital in Babol, Iran.

This cross-sectional study was conducted on 36 patients with mediastinal lymphadenopathy who were admitted to Shahid Beheshti Hospital in Babol (April 2009-March 2020) and underwent mediastinoscopy. Recorded medical information of all patients without known lung cancer under mediastinoscopy was reviewed. Mediastinoscopy was performed by a specialist doctor for all patients and the biopsy sample was sent to Shahid Beheshti Hospital Pathology for final diagnosis. Descriptive data were analyzed using SPSS25 software at a significance level of 0.05.

The mean age of the patients was 47.97±11.04 years (range: 28-76 years). The majority of patients were women (n=27; 75.00%). According to the pathology results, the final diagnosis for 33 people (91.67%) was benign, and 3 people (8.33%) were diagnosed with malignant. The most common pathology result was sarcoidosis with 23 cases (63.90%), active infection in 4 cases (11.11%), and squamous cell carcinoma in 3 cases (8.33%). Other benign results were reported with the frequency of one case (78.2%). Pathology findings had no significant relationship with the age and gender of patients (P<0.05).

Based on the findings of the study, it can be concluded that mediastinoscopy can help determine the causes of mediastinal lymphadenopathy and it is still a reliable method for examining mediastinal lesions.

Core needle biopsy (CNB) is less invasive and has fewer side effects compared to surgical procedures, and provides accurate information about the nature of the tumor. The aim of this study was to evaluate the efficacy of CNB in the diagnosis of the cause of lymphadenopathy.

In this study, 153 patients with lymphadenopathy underwent CNB from 2014 to 2018. Immunohistochemistry staining with appropriate markers was performed. Excisional biopsy, clinical and radiological data were evaluated using spss-21 softwere, data were analyzed by one way ANOVA and tukey test (p<0/05).

Diffuse large B-cell lymphoma was more frequent (41%). Histopathological diagnosis of core needle biopsy was correct in 83.23% of the patients,among them 11.11% were confirmed by excisional biopsy and 88.88% by clinical and radiological findings. There was a significant relationship between the mean age of the patients and location of lymphadenopathy (P = 0.02) and also between the mean age and pathology diagnosis (P<0.001). The accuracy, sensitivity, and positive predictive value of CNB were 90%, 100%, and 90%, respectively.

Diagnosis of the cause of lymphadenopathy by CNB was correct in most cases and its diagnostic efficacy was confirmed. The present results recommend CNB as a suitable method without side effects for investigation of the cause of lymphadenopathy.

Acute myeloid leukemia (AML) is a malignant hematological disorder which has numerous manifestations at the initial step such as infections and hemorrhagic signs. This is the first report in which the diagnosis of AML was made after managing of Bartholin gland site swelling and pain as the chief complaint of a patient.

Herein, we present a young girl who was referred to us in our tertiary level hospital, Firoozgar Hospital, Tehran, Iran, in october, 2017 just with pain and swelling of the left Bartholin gland. At first, it was suspected to be a cyst or abscess of Bartholin gland, she did not have any history or symptoms of infection on comprehensive physical examinations such as pneumonia, meningitis, Nevertheless, the ultimate diagnosis of AML was made after generalized and precise systemic examination and laboratory findings were done. According to the guidelines for the treatment of AML, systemic chemotherapy with multiple drugs was given immediately but unfortunately, she died due to severe septicemia which was resistant to broad-spectrum antibiotics and disseminated intravascular coagulation.

Based on our searching, this is the first case. Because we expected other more common symptoms of acute lukemia, systematic and precise generalized examination must be performed gently in all of the patients even in women just with genital symptoms as their chief compliant for instance, pain and swelling of Bartholin gland. Finally, not focusing just on the perineal site and detailed examination for all parts of the body may reveal an accurate diagnosis of the main underlying disease.

Malignant lymphoma of the oral region is uncommon and accounts for approximately 3.5% of all oral malignancies. Non-Hodgkin’s lymphoma occurs primarily in adults, although children may also be affected, particularly by the more aggressive intermediate and high-grade forms. The condition most commonly develops in the lymph nodes, but so-called extra nodal lymphoma is also found. In children, extanodal lymphoma is more common. The presentation can be as a non tender mass mostly in cervical, auxiliary, or inguinal regions that has been enlarging for months. In the oral cavity, lymphoma appears usually as extra nodal disease. The malignancy may develop in the oral soft tissues or centrally within the jaws. Soft tissue lesions appear as non-tender, diffuse swelling; they most commonly affect the buccal vestibule, posterior hard palate, or gingiva. The patient may complain of paresthesia, particularly with a mandibular lesion (numb chin syndrome). Case report: An 8-year-old boy was visited in the Oral Medicine Department of Mashhad Dental School with the chief complaint of permanent tooth mobility in the oral cavity for 15 days. The patient also had a history of bone pain mainly in lower lip for the last month and Bell’s palsy (left side) was observed which had been occurred since 7 days before. Simultaneously, the patient had malaise, anorexia, bone pain, illness, lymphadenopathy (head and neck), and flu like signs and symptoms, fatigue and leukocytosis. Under clinical diagnosis of lymphoma, the patient was referred to pediatric hematologist-oncologist. Our diagnosis, none Hodgkin’s lymphoma (NHL), was confirmed by the report of lymph node biopsy.

Dentists can play an important role in the early detection of the malignant lymphoma of the oral cavity. NHL primarily appears in the head and neck. It is typically characterized by a swollen, non-painful lymph node although other presentations may pose significant diagnostic problems and frequently lead to misdiagnosis and mistreatment.