جستجوی مقالات مرتبط با کلیدواژه « مس » در نشریات گروه « پزشکی »

Wounds are one of the most crucial health issues, especially when they are infected with pathogenic microbes. Nowadays, nanofibers have been designed with antibacterial properties to serve as an effective solution for wound healing.

In this research, a polyethylene oxide/copper/peptide nanocomposite was
designed using electrospinning at a ratio of 98/1/1 mg. Then, the characteristics of the nanocomposite were analyzed by scanning electron microscopy (SEM), tensile testing and differential scanning calorimetry (DSC). In addition, the antibacterial properties of the prepared nanofibers were evaluated against standard strains of Staphylococcus aureus and Escherichia coli, and the antioxidant effects of the said composite were evaluated.

The SEM results showed that copper and peptide nanoparticles were well spread on the surface of the polymer and the tensile test results revealed that this sample has relatively high tensile strength. Also, the designed nanocomposite was resistant to heat according to the DSC and had antibacterial effects against standard microbial strains and antioxidant properties.

The results of this study showed that the designed nanofibers can be used as a compound with antimicrobial and antioxidant properties in the healthcare and hygiene industries to produce wound dressings.

Children with autism spectrum disorders (ASD) are at risk of insufficient nutrient intake due to inappropriate eating habits, problems in sensory perception, and choosing monotonous foods. Minerals play an essential role in the central nervous system, and their deficiency or excess can cause a variety of health issues and can contribute to the development of ASD. This study aimed to compare the dietary intake of zinc, copper, selenium, and manganese in two groups of children, with ASD and healthy controls, in Gorgan City, Iran.

In this study, the food intake of 35 ASD children aged 6 to 12 years and 70 healthy children was recorded using the semi-quantitative Food Frequency Questionnaire. The average daily intake of zinc, copper, selenium, and manganese was estimated using ShaFA software.

There was no statistically significant difference in the dietary intake of zinc, copper, and selenium; however, the intake of manganese was significantly lower in ASD children (median±IQR: 2.39±1.83) than in healthy children (median±IQR: 3.24±1.94; P=0.03).

Considering the existence of problems related to eating habits in children with ASD, the results of this study showed the necessity of frequent and regular nutrition assessment for ASD children. Studies with larger sample sizes are recommended.

Soil serves as the primary repository for microplastics, yet their impact on soil-dwelling organisms remains insufficiently understood. This study aims to investigate the influence of varying concentrations of microplastics in soil on the absorption of Cd and Cu by Eisenia fetida within an artificial soil matrix.

The artificial soil consisted of kaolinite clay (20% dry weight), quartz sand (70% dry weight), and Sphagnum peat (10% dry weight). Microplastics, derived from worn-out tire rubber, were incorporated into the soil to establish four concentration levels: 5, 25, 50, and 100 grams of tire microplastics per 500 grams of dry soil. Each treatment was inoculated with ten mature earthworms, weighing between 3.0 and 5.0 grams. After 14 days, samples were collected for ICP analysis.

: The highest accumulation of both metals was observed in treatments with 25, 50, and 100 grams of tire microplastics. The results demonstrated significant disparities in copper and cadmium accumulation in the tissue samples following the introduction of tire wear particles, indicating an augmenting effect of tire particles on metal uptake by the samples. Statistically notable reductions (p < 0.05) in Cd and Cu concentrations were noted in both the control soil and soil containing microplastics, particularly in the 100-gram microplastic treatment for Cd and the 50-gram microplastic treatment for Cu.

Exposure to a combination of microplastics, Cd, and Cu has more pronounced adverse effects on E. fetida, and microplastics enhance the bioavailability of heavy metal ions within the soil environment.

Mining is one of the important economic activities all over the world. It causes the release of various emissions, especially heavy metals in the soil, due to the weak exploitation and improper disposal of mineral wastes. Different techniques are used for soil remediation and heavy metal extraction; including the electrokinetic method (so effective in fine-grained soils). In this research, the electrokinetic process was used to extract copper from the waste of the mine in Birjand.

In this research, a 24 cm long PVC reactor was used. The retention time was 2, 4, and 6 days and the voltage gradient was 1 V/cm. Graphite electrodes and electrolyte solutions of nitric acid and citric acid were investigated for copper extraction. The electrode polarity was alternately changed in order to pH control and improve the extraction process.

According to the results, the highest removal efficiency (54%) was obtained after 6 days using 0.1 M citric acid and distilled water in the anode and cathode reservoir, respectively. Further, by 24-hour polarity reversing, the copper removal efficiency increased to about 60%.

The use of citric acid in anode was more effective than nitric acid, leading to more copper removal. In addition, by periodically polarity change and keeping the soil pH in the neutral range, further dissolution of the metal and reducing its sedimentation in the soil occurred. As a result, the rate of its transfer outside the treatment area and removal efficiency increased.

Type 1 diabetes is a metabolic disorder in glucose metabolism. Poor glycemic control in type 1 diabetes mellitus (T1DM) commonly leads to oxidative stress and further diabetic complications. Trace elements, such as magnesium (Mg), zinc (Zn), and copper (Cu), play a role in the process of lipid peroxidation, pathogenesis, and exacerbation of diabetic complications. The present study aimed to investigate trace elements in children and adolescents with type 1 diabetes in Golestan province in 2022.

This case-control study was conducted on 26 children with type 1 diabetes and 26 non-diabetic children. After 12 hours of overnight fasting, 2 ml of venous blood was taken from the samples. Data were analyzed in SPSS software (version 18) using chi-score and logistic regression tests at a significance level of 0.05.

The serum level of zinc was lower than the normal level in 42.3% of children with diabetes and 15.4% of the non-diabetic group. Moreover, the serum levels of copper and magnesium were lower than normal in 7.7% and 11.5% of children with diabetes, respectively. Body mass index, gender, and duration of diabetes demonstrated no significant relationship with zinc, copper, and magnesium levels.

Having type 1 diabetes causes a decrease in serum levels of zinc and copper in children. According to body mass profile, gender and duration of diabetes are not associated with this serum reduction.

Heavy metals, as one of the important groups of pollutants in the aquatic environment, enter aquatic ecosystems as a result of natural and human activities. These metals may be accumulated in the body of aquatic animals, including fish, and are a potential health hazard for ecosystems and living organisms, especially for humans. The present study was conducted with the aim of investigating the concentration of three heavy metals mercury, arsenic and copper in the muscle tissue, liver and skin in two species of two species of Otolithes ruber and Sphyraena forsteri in the fishing ports of Konarak and Pozm.

36 fish samples were collected from Kanarak and Pezem ports. After preparing the samples, the concentration of heavy elements mercury, arsenic and copper was determined by the atomic absorption method. Data analysis was done using SPSS statistical software, version 20 and covariance tests and Pearson correlation test at a significance level of 0.05.

There was no significant difference between the amounts of the studied metals in muscle tissue, liver and inflamed and cauterized skin (p<0.05). The average concentration of heavy metals copper, mercury, and arsenic in the muscle tissue of Otolithes ruber 3.61, 0.01, and 0.02 respectively, and Sphyraena forsteri 2.38, 0.01, and 0.02 μg / g, respectively.

The concentration of heavy metals in the muscle tissue was lower than the international standards of WHO and FAO.

Cadmium has similar chemical and physical properties to metals such as zinc and copper, can be transferred to cells via an ionic and molecular process, and disrupts cell biological functions and homeostasis. The aim of this study was to investigate the effect of cadmium chloride on serum and tissue levels of zinc and copper, Also, the protective role of N-acetylcysteine (NAC) in preventing cadmium-induced toxicity and tissue inflammation in the lung tissue of rats exposed to single-dose and continuous-dose cadmium.

30 male Wistar rats were randomly divided into five groups of six in this interventional-experimental study. The control group only received regular water and food. The first group received a single dose treatment of 80 mg/kg of cadmium chloride on the first day of the study, while the second group received a continuous dose of 2.5 mg / kg of cadmium chloride every other day for 4 weeks.  On the first day of the study, the third group received a single dose of 80 mg / kg cadmium chloride along with 50 mg / kg N-acetylcysteine. For four weeks, the fourth treatment group received a continuous dose of 2. 5 mg of cadmium chloride along with 50 mg of N-acetylcysteine. Cadmium chloride and N-acetylcysteine were administered to the animals via gavage. At the end of the treatment period, blood samples from the heart were taken to determine the level of the elements. After anesthesia, lung tissue was removed from the chest and part of it was used for histological work, while the other part was used to measure element levels.

Treatment with cadmium chloride showed a decrease in serum copper levels in the second treatment group compared to the control group (P-value <0.01). In addition, cadmium chloride treatment in the second treatment group compared to the control group caused a significant reduction in copper tissue level (P-value <0.001). Cadmium chloride treatment reduced serum zinc levels in the second treatment group compared to the control group (P-value <0.01). Tissue level of zinc in the second treatment group compared to the control showed a significant decrease (P-value <0.001). Simultaneous treatment of cadmium chloride and N-acetylcysteine ​​in the fourth treatment group as a continuous dose compared to the second treatment group caused a significant increase in serum copper level (P-value <0.05). And copper tissue level in the fourth treatment group increased significantly compared to the second treatment group (P-value <0. 001). Also, simultaneous treatment of cadmium chloride and N-acetylcysteine ​​in the fourth treatment group showed that serum zinc level (P-value <0.05) and tissue level of zinc (P-value <0.01) were significantly higher than the second treatment group.

Continuous N-acetylcysteine administration reduces the toxicity of cadmium chloride in rats exposed to a continuous dose of cadmium chloride and improves serum and tissue copper and zinc levels.

Gastric cancer is an important, prevalant and second most fatal cancer in the world. Previous studies show heavy metals have various roles in human health. Heavy metals are known to be associated with various cancers but their function in gastric adenocarcinoma is unclear. In this study we examined serum level of these metals in gastric adenocarcinoma patients compared to control group.

In total, 114 subjects (54 controls and 60 cancer patients) were included in this study. We took blood samples from 60 known cases of gastric adenocarcinoma hospitalized in oncology Ward of Valiaasr Hospital and 53 none cancerous patients hospitalized in other wards of the Valiasr hospital, as control group. After sample preparation, serum concentration of  Zinc, Cadmium, Lead and Copper were determined by polarography and the obtained data were analyzed by SPSS software.

Serum level of Copper was significantly higher in patients with gastric adenocarcinoma compared to control group (P-Vlue= 0.04). No significant differences were  found in serum  level of zinc, lead and cadmium in gastric adenocarcinoma patients compared to control group (P-Value > 0.05), however the mean concentration of zinc and Lead were higher in cancerous patients.

Findings in this study appear to support that Copper overload may be risk factor of Gastric Adenocarcinoma but to find out the exact roles of theses heavy metals, more extended studies are needed. Recently, tendency to use copper containing dishes has been increased in our society, so necessary warnings should be given to the community as to the possible carcinogenicity of copper.

Food products contain various chemicals, including essential and nutritious elements, toxic and harmful elements, among which dairy products are widely consumed among people and it is necessary to check the number of elements such as zinc and copper that are essential for the vital activities of the body and toxic heavy metals such as cadmium and lead that enter dairy products due to environmental pollution, need to be controlled and monitored.

To investigate the amount of zinc, copper, lead and cadmium metals in yoghurt and doogh, the products of 12 high-consumption factories in Tehran, which included 9 brands of yoghurt and 9 brands of doogh, were collected by Differential Pulse Anodic Stripping Voltammetry method due to High sensitivity and selectivity Dry Ash method was used to prepare the sample and the samples were injected into the tube of the machine and to draw the calibration curve, the method of adding the standard edition (three times in each step) was used. The average concentration of zinc was processed by using SPSS software.

For yoghurt and doogh the average concentration of zinc was 27.08 ± 4.56 and 8.72 ±1.53 µg/l respectively, and for copper 4.94± 0.70 and 3.21± 0.59 µg/ l, and for cadmium 6.34 ± 0.73 and 4.05± 0.64µg/l and for lead was 4.84 ± 0.69 and 3.09 ± 0.62 µg/l, respectively that according to the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) and the USDA, the concentration of all metals was below the permitted level and there was no significant difference between the concentrations of yoghurt and doogh samples. (pvalue>0.05)

Considering the increasing consumption of yoghurt and doogh dairy products in the household food basket and its serious role in daily nutrition, therefore, it seems necessary to study and control the quality of zinc and copper and lead and cadmium micronutrients contaminants.

As, copper sulfate acts as an enzyme cofactors, it can affect oral tissues. Therefore, this study aimed to evaluate the effect of copper sulfate on soft and hard oral tissues.

This animal study was conducted on 14 male rats (200-250 gr). The rats were divided into two groups of treatment and control. The treatment group received oral copper sulfate in 80 days. The rats were anesthetized and blood samples were taken from their hearts. Then, their tongue and jaw were also removed for microscopic examination. Liver serum enzymes were measured. Tissue samples were examined for inflammation, number of blood vessels per unit area, percentage of fibrotic tissue, necrosis, mucosal ulcer, atrophy, and superficial epithelial hyperplasia, bleeding and pulp calcification. Data were analyzed by SPSS 22 using independent t-test (p<0.05).

AST and ALT enzymes showed significant differences, but the ALP enzyme did not show any significant difference. The number of blood vessels in the gums and tongue showed a significant difference. Inflammation, fibroticization, necrosis, mucosal ulceration, hemorrhage, atrophy, and superficial epithelial hyperplasia and pulp calcification were not found in any of the tongue and jaw specimens.

Copper sulfate intoxication increased the amount of angiogenesis in the oral tissues and it had no role in inflammation, hemorrhage, atrophy or epithelial ulcer, fibrotic tissue, necrosis and pulp calcification.

The use of copper based fungicides is a crucial part of agricultural operations in vineyards, increasing productivity and crops. However, the long term application of fungicide could increase the copper concentration in the vineyard soils.


In this study, soil and water chemical parameters including copper contamination, pH and EC as well as soil organic matter and texture were determined in 23 stations across Malayer vineyards in a completely randomized layout. 


The soil texture of vineyards was a type of sandy loam in the study area which is suitable for grape seedlings growth.Copper concentration ​​was significantly higher than the level required for optimum grapevine growth but less than the contamination level. The water and soil pH and soil organic matter content were in optimum condition. While soil EC was in normal range according to the Ministry of Agriculture standard, the EC value of water was above the optimum value, which can be due to the unauthorized deep-water wells and exposure to the saline watertable.


According to the results, it seems that the sharp increase in copper concentration in the Malayer vineyard could be a result of fungicides application as well as pollution transmittal of mining, factories and chemical and animal fertilizers application in the study area.

In recent decades, industrial, agricultural and urban activities have caused pollution and accumulation of heavy metals in soils and plants which directly or indirectly affects humans and animals lives. Nowadays, pollutant accumulation in most agricultural products is much higher than the permissible limit due to the excessive use of fertilizers.
In this study, the accumulation and distribution of heavy metals were investigated in different organs of rats under various nutritional conditions. The experiment was conducted in a completely randomized design with greenhouse strawberry treatments in three groups. Different groups of rats (27 rats) were fed strawberries infected with heavy metals by oral gavage within a three-month period.Regarding the average weight of rats, 0.5 gram of fresh strawberry was considered for each rat.
Results showed that the concentration of studied heavy metals in the strawberries were 7.7, 26 and 3.2 mg / kg for cadmium, lead and copper respectively, which were higher than Iranian standard level. The statistical results showed that there was a significant difference between the different organs in the intake of the heavy metals, so that in the infected treatment, the most and lowest amounts of cadmium were in the kidney (0.41 g / day) and the brain (0.24 g / day), respectively. Heavy metals caused reduction in the rate of weight gain of rats. The accumulation of these elements were higher in the kidney, liver and pancreas than other organs. The least accumulation of heavy metals was related to the rat’s brain, while highest amount of the heavy metals accumulation was in the kidney

Vegetables have a high capability in absorbing and storing heavy metals and the gathering of these materials in the human body causes unpleasant effects. The aim of the present study is the evaluation of the density and pollution caused by the elements cadmium , lead, mercury, copper, and nickel in leek, potato, and tomato in some farms in Khorramabad city.
In one experimental study, after the sampling of farms and preparing samples, digestion and combination with HCL, the density of the elements cadmium , lead, mercury, copper and nickel were determined by means of atomic absorption apparatus in a graphite furnace. To statistically process the findings, Spss software was used, and Excel software was used to present the findings. Finally, the results were compared with WHO standards.
The results show that the average density in heavy metals in various vegetables: levels of lead in leek (0.252), in tomato (0.304), and in potato (0.155) and the cadmium levels in leek (0.147), in tomato (0.216), in potato (0.081). The levels of nickel are as the follows: leek(47,98), in tomato (34,612), in potato (32,04). The levels of copper were as follows: in leek (0.149), in tomato (0.155), and in potato (0.148)ppm. Mercury was either absent or in trace amounts in the investigated vegetables.
the reason for the high levels of lead and cadmium compared with the permissible limit is probably due to too much phosphate fertilizers being used by farmers, the use of sewage slime, insecticides, fungicides, the using of too much animal residues and urban waste and also the closeness of agricultural fields to roads.

Background and Copper is a trace element that is used in various industries. Copper nano-particles are being used in different skin care products, lubricants, oils, polymers, metal covers, plastics, inks, etc. Previous studies have shown that both copper sulfate and copper nano-particles can induce cellular genotoxicity and DNA damage. So, this study aimed at evaluating and comparing genotoxicity in copper nanoparticles and copper sulphate. Assessment of oxidative stress as a mechanism of toxicity was also done.
In this experimental study, blood samples were taken from healthy donors and lymphocytes were separated. Then, lymphocytes were divided into ten groups including control, cisplatin (12µM), different concentrations of copper sulphate (10, 25, 50, 100 nM), and copper nano-particles (10, 25, 50,100 nM). After 24 h incubation, genotoxicity was investigated by micronucleus and also oxidative stress markers including lipid peroxidation and glutathione.
Incubation of blood samples with copper sulfate and nano oxide copper increased the number of micronucleus in lymphocyte. In similar concentration, this increase was higher in nanoparticles group compared with that of the copper sulphate. Also, in both groups receiving copper sulfate and nano oxide copper, lipid peroxidation marker (MDA) and glutathione oxidation increased significantly (p The genotoxicity of copper nanoparticles was found to be higher than that of the copper sulphate. Also, oxidative stress plays a role in genotoxicity of copper sulphate and nano-particles.

Copper and manganese play antioxidative roles in cells. Since gamma radiation is frequently used at medical imaging centers, we evaluated possible changes in serum levels of copper and manganese among nuclear medicine staff.
This cross-sectional study enrolled 30 nuclear medicine staff and 10 individuals as the control group. Blood samples of 20 ml were collected and centrifuged at 4000 rpm for 7 min to separate the sera for measuring copper and manganese through atomic absorption spectroscopy (AAA) with graphite furnace.
The mean of copper concentration in the control group (93.85±25.33) was a bit higher than that in the irradiated group (85.6±21.66); however, this difference was not significant (p=0.32). A positive linear correlation was observed between exposure time and the reduced level of copper; however, this relationship was not statistically significant (p=0.05). An insignificant difference was observed in the mean of manganese concentration between the two groups and its relationship with exposure time.
Reduced copper level can be considered as one of the possible mechanisms for gamma radiation effect on cells, which may be associated with oxidative damage. However, it needs further studies.

Production of skin dressings or substitutes is one of the most important tissue engineering fields. Since copper is an important agent in skin extracellular matrix synthesis, we investigated the effect of collagen-gelatin-bioglass scaffolds containing copper in accelerating the healing process of full-thickness skin wound in mouse model.
We used 12 mice with two identical skin wounds on their back (with 5 mm diameter, circular, and full-thickness), one wound as control, second dressed with collagen-gelatin-bioglass scaffold, and third dressed with collagen-gelatin-bioglass scaffold containing copper. After 14 days, the wound healing process was analyzed using both macroscopic and microscopic (after hematoxylin and eosin staining) methods.
Findings: The wound dressings had porous structure, and were biocompatible. They improved the healing process of full-thickness wound in mouse model. This process was statistically much better in the dressings comprising copper (P Since wounds dressed with collagen-gelatin-bioglass scaffold containing copper improved wound healing in animal models, it can be suggested as a new approach in design and synthesis of wound dressings for human.

Thyroid hormones play a role in cell growth regulation, metabolism, and body trace elements. These hormones, copper and zinc are effective on fertility. The aim of this study was to evaluate the effect of thyroid function on the amount of copper and zinc in rat seminal plasma.

Twenty four male Wistar rats divided in 3 groups (n = 8) including: control group, hypothyroid groups which treated by methimazole low dose (20 mg in 100 ml of drinking water) and which treated by methimazole high dose (100 mg in 100 ml of drinking water). At the end of a 42-day treatment period, blood samples were taken from animals under deep anesthesia. Serum samples were collected from blood, and semen plasma samples were collected from seminal vesicle. The body and testis of animal were weighted. Hematocrit (HCT) was determined. Serum levels of thyroxin hormone (T4) were measured by Radioimmunoassay. The content of the Copper (Cu) and Zinc (Zn) in the seminal plasma was determined with inductively coupled plasma optical emission spectrometry.

Methimazole decreased the serum T4 level (p < 0.001), Zn in the seminal plasma (p < 0.001) and relative weight of the testes (p < 0.01) in a significant and dose-dependent manner. Hematocrit level decreased in two hypothyroid groups (p < 0.001). The testis weight and Cu in the seminal plasma reduced in the high dose treatment group (p < 0.01).

Methimazole or hypothyroidism induced by methimazole attenuated zinc concentration in seminal plasma, testes relative weight and Hematocrit level. However, copper reduction in the seminal plasma occurred only by high dose of methimazole.

Tobacco use in various ways such as cigarettes, hookahs, and nas is one of the most important and preventable factors in illness, disability and premature death in the world. Considering the importance of hookah consumption and its impact on the health of people in the community, studies in this regard will be significant. In this regard, the aim of present study was to determine the levels of heavy metals (zinc (Zn), copper (Cu), lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg)) in the tobacco and hookah water used in cafes in Sanandaj city in 2017.
Material and In this descriptive-analytical (cross sectional) study, two popular and common brands of hookah tobacco were selected in Sanandaj (Crystal and Palm), and each of the brands was evaluated for three flavors (dassib, lemon, and mint). A total of 36 tobacco samples (before and after use) and 36 samples of water (before and after use) were investigated. The samples were prepared by acid digestion and finally, the concentrations of metals (Zn, Cu, Pb, Cd, As, and Hg) was measured by atomic absorption.
The results of this study showed that the highest and lowest concentrations of metals were related to Zn (11/05 µg/g) and As (1/35 µg/g) respectively. In general, according to the results, the order of the metals was Zn > Cu > Pb > Cd > As. The results showed that there was a significant difference between Pb in burnt and unburned tobacco, and Pb in burnt tobacco is more than unburned tobacco. In contrast, no difference in the mean of the other metals before and after use has not been made. The results of comparison of metals before and after the use of hookahs in hookah water showed that there was a significant difference in Cu, Zn, and Pb. Moreover, there is no significant difference between the two brands in terms of metals as well as the different taste of the tobacco (p> 0/05).
The results of this study showed that the concentration of metals in tobacco samples distributed in Sanandaj was higher than the standards of WHO. The values indicated were high levels of metals in aromatic tobacco samples, which also require more attention to protect people's health and ways to reduce tobacco use.